Thiago Carvalho @cyrilpedia@qoto.org

#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

April 26, 1848, 25-year-old British naturalist, co-discovered of evolution & pioneer of biogeography Alfred Russel Wallace departs the UK to South America, where he will study animals & plants for the next 4 years.

https://tinyurl.com/yy59dmuy

'In this review, we will briefly introduce the current treatment paradigms for PDAC and then expand upon the biological underpinnings driving its pathogenesis and progression.'

https://www.cell.com/cell/fulltext/S0092-8674(23)00142-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423001423%3Fshowall%3Dtrue

Positive and Relaxed Selective Pressures Have Both Strongly Influenced the Evolution of Cryonotothenioid Fishes during Their Radiation in the Freezing Southern Ocean https://doi.org/10.1093/gbe/evad049 #science #evolution #biology #genome #SciComm #evolgen_paper

'Given the vaccine nationalism seen during COVID-19, and that pandemic treaty negotiations are still nascent, there is a risk that governments, particularly those in high-income countries, will use advance purchase agreements to secure national supply of scarce vaccine resources during a future influenza pandemic.'

https://www.nature.com/articles/s41591-023-02340-5

'Cancers that pass from one host to another are rare in nature, but can have devastating effects, says study co-author Rodrigo Hamede, a disease ecologist at the University of Tasmania in Hobart. “In a matter of 10 years, we lost between 60–70% of the overall [devil] population,” he says.'

https://www.nature.com/articles/d41586-023-01349-7

'Still, in December, when Elon Musk joked on Twitter that his “pronouns” were “Prosecute/Fauci,” it felt like the cresting of a turning tide against the man who had played essentially that role for the first three years of the pandemic. At least 30 state legislatures have passed laws limiting public-health powers in pandemics.'

https://www.nytimes.com/interactive/2023/04/24/magazine/dr-fauci-pandemic.html

'There was no military reason to bomb Gernika. No barracks or munitions factories of significance were to be found there. Nor was the town on the front lines. Politically, people identified it with Basque culture and independence. Attacking it was the equivalent of targeting the Liberty Bell in Philadelphia, but not the navy yard to the south of the city.'

https://www.zocalopublicsquare.org/2023/04/24/guernica-antiwar-art-still-matters/ideas/essay/?ref=thebrowser.com

'To appreciate this catastrophe, we’ve got to move the focus off humans, at least for a bit. H5N1 is devastating the world’s birds. Eagles are dropping dead, as are great horned owls and peregrine falcons and pelicans. Twenty California condors recently died of what’s suspected to be avian flu — 10 are confirmed so far. It’s the worst thing that has happened to wild birds since the pesticide DDT.'

https://www.nytimes.com/2023/04/23/opinion/bird-flu.html

Obrigado

#25AbrilSempre

#25AbrilSempre

O momento único.
Singularidade.
Os átomos alinharam-se,
as covalências ligaram-se,
e
mudou-se a vida.
E ele mordia os lábios.

Frogs, glazed #stoneware by @hunchbacksociety

#ceramics #ceramicart #handmade #artgallery #artmastodon

https://madalenaparreira.com/Hunchbacksociety

@BiologyOpen
celebrates #DNAday today, as the movement highlights the 20th anniversary of the #HumanGenomeProject and 70 years since the discovery of #DNAdoublehelix - take a look at
@BiologyOpen
and one of its #OpenAccess articles now:
https://journals.biologists.com/bio/article/9/2/bio044222/222749/Whole-genome-fingerprint-of-the-DNA-methylome?searchresult=1
#dnaday2023