Thiago Carvalho @cyrilpedia@qoto.org

'We do seem to be at the stage of human intellectual decay where anyone who is a multibillionaire is also automatically described as a “philanthropist”, when in many cases “misanthropist” would be more supported by the evidence.'

https://www.theguardian.com/commentisfree/2023/may/26/jeff-bezos-money-lauren-sanchez-europe

Cholesterol & anti tumor T cell immunity:

"We analyze the cholesterol atlas in the tumor microenvironment and find that intratumoral T cells have cholesterol deficiency, while immunosuppressive myeloid cells and tumor cells display cholesterol abundance. Low cholesterol levels inhibit T cell proliferation and cause autophagy-mediated apoptosis, particularly for cytotoxic T cells"

#Immunology #immunotherapy #immunooncology #CancerImmunity

https://www.sciencedirect.com/science/article/abs/pii/S1535610823001423?via%3Dihub

'We are starting a clinical trial where 50 patients will be treated with the antiviral drug Paxlovid and 50 will be given a placebo. This is to probe whether persistent virus infection may be causing long Covid in a subset of people. We’re not giving them the conventional five-day course, but a 15-day course of treatment, to see if that can eliminate the source of the problem, which is the remnants of replicating virus'

https://www.theguardian.com/society/2023/may/27/immunologist-akiko-iwasaki-we-are-not-done-with-covid-not-even-close

Pathogenic forms of the ANT1 protein lead to harmful consequences in yeast and mice by clogging the channels that allow mitochondria to import proteins. https://elifesciences.org/digests/84330/a-novel-way-to-cause-disease?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Postdoctoral Scientist - Cell Cycle/Cell Metabolism

Nationwide Children's Hospital

Post-Doctoral Researcher Fellow or Research Associate positions are available in the Center for Childhood Cancer and Blood Diseases.

See the full job description on jobRxiv: https://jobrxiv.org/job/nationwide-childrens-hospital-27778-postdoctoral-scientist-cell-cycle-cell-metabolism/?...
https://jobrxiv.org/job/nationwide-childrens-hospital-27778-postdoctoral-scientist-cell-cycle-cell-metabolism/?feed_id=46669

Wow, those are some high #ciclosporine levels at baseline!

#transplantation #nephrology

Evaluation of drug interaction between cyclosporine and lercanidipine: a descriptive study https://pubmed.ncbi.nlm.nih.gov/37236776/?utm_source=Feedly&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1pq-4TZ0w1pCinD_GHL9_2WNbZ7J_Sy6TyOPWav10SQEpUpQS6&fc=20230515214155&ff=20230527124951&v=2.17.9.post6+86293ac

Master or PhD positions

University of Ottawa

Master and PhD in #Canada fully funded positions in #bioinformatics

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-ottawa-27778-master-or-phd-positions/?feed_id=46627

#ScienceJobs #hiring #research #bioinformatics #machine learning
Ottawa #Canada #PhDStudent #ResearchAssistant
https://jobrxiv.org/job/university-of-ottawa-27778-master-or-phd-positions/?feed_id=46627

Great opening by Carolyn Wilke:

"Costello the octopus was napping while stuck to the glass of his tank at the Rockefeller University in New York. He snoozed quietly for half an hour, and then entered a more active sleep stage, his skin cycling through colors and textures used for camouflage — typical behavior for a cephalopod.
But soon things became strange."

https://www.nytimes.com/2023/05/25/science/octopus-nightmare-dream.html

If you're in Lisbon, @joanagsa @JoanaLA & I will discuss the importance of failure in scientific progress & what this means for how we design our research institutions.

This Sunday, at Feira do Livro

Postdoc position - Lipid Network Reconstruction & Computational Modeling

Osnabrück University

The Holthuis Lab at Osnabrück University is looking for a Postdoc to work on LIPID NETWORK RECONSTRUCTION & COMPUTATIONAL MODELING FOR IMDs

See the full job description on jobRxiv: https://jobrxiv.org/job/osnabruck-university-27778-postdoc-position-lipid-network-r...
https://jobrxiv.org/job/osnabruck-university-27778-postdoc-position-lipid-network-reconstruction-computational-modeling/?feed_id=46620

'El gran peligro, coinciden los expertos, es que una vez que las vacunas estén firmemente establecidas en África, y los casos y muertes empiecen a descender, el riesgo de resurgimiento de la malaria será alto. Bawa recuerda que “la historia ha demostrado que esto es lo que ocurrió en Latinoamérica y otras partes del mundo que llegaron a un buen punto y entonces se relajaron, y antes de que se dieran cuenta, se produjo un rebrote”.

#malaria

https://elpais.com/planeta-futuro/red-de-expertos/2023-05-25/las-nuevas-vacunas-contra-la-malaria-un-exito-con-algunas-sombras.html