Thiago Carvalho @cyrilpedia@qoto.org

"In this article – which builds on a preprint we posted in March 2022 (Corneille et al., 2022) – we describe a range of persuasive communication devices that can be used to exaggerate the importance of and/or hide the weaknesses of scientific work, and urge authors to exercise caution when thinking about using such devices"

https://elifesciences.org/articles/88654

Interesting addition to the toolbox, if you're working on #microglia:

"We generated a constitutive Cre line controlled by the microglia signature gene Crybb1 that produced nearly complete recombination in embryonic brain macrophages (microglia and border-associated macrophages [BAMs]) by the perinatal period, with limited recombination in peripheral myeloid cells."

https://www.cell.com/immunity/fulltext/S1074-7613(23)00040-7

Be there or be square (if you're Lisbon):

Exposição "Oubliette", inaugura 6ª feira dia 16 Junho às 18h30 na Biblioteca Camões em Lisboa. Pieces by Ana Jotta, Constança Arouca, Jorge Nesbitt & Madalena Parreira
Texts by H. Manfredsenjensen

Opening on Friday, June 16th at Biblioteca Camões, Lisbon (Largo Calhariz 17), 18h30.

"We have established a #Helicobacter-induced accelerated disease progression mouse model, which involves infecting mice deficient in the myeloid differentiation primary response 88 gene (Myd88-/-) with H. felis. Using this model, we report here that that progression of H. felis-induced inflammation to high-grade dysplasia was associated with activation of type I interferon (IFN-I) signaling pathway and upregulation of related downstream target genes, IFN-stimulated genes (ISGs)." #Preprint

https://www.biorxiv.org/content/10.1101/2023.06.04.543598v1?med=mas

MPI postdoc survey:

"Approximately 27% of all postdocs are parents, and almost 40% of German postdocs are parents. We observe that female postdocs with caring responsibilities stand out from other subgroup analyses. We find that mothers are most unhappy, depressed, anxious, stressed by care work and their work as postdocs. They report more personal conflicts (e.g., with their partner) and are most socially isolated."

https://www.postdocnet.mpg.de/134932/survey-2022

"Françoise Gilot, an accomplished painter whose art was eclipsed by her long and stormy romantic relationship with a much older Pablo Picasso, and who alone among his many mistresses walked out on him, died on Tuesday at a hospital in Manhattan. She was 101."
(photo credit Robert Capa/International Center of Photography/Magnum Photos)

https://www.nytimes.com/2023/06/06/arts/francoise-gilot-dead.html?action=click&module=Well&pgtype=Homepage&section=Obituaries

"Compared with other bacteria, #Salmonella, a facultative anaerobe, has higher motility and accumulation in tumors and a special advantage in targeting tumor quiescence, possibly via the chemoreceptors of Salmonella"

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00189-1

SCOTUS rules agains Amgen, 9-0. An important decision because Amgen wanted to enforce a patent on any monoclonal against a particular target (the PCSK9 receptor), which would have set a terrible precedent.

"This case does not involve those antibody-specific patents. Instead, it involves much broader patents Amgen obtained, which cover every antibody that binds to the same sweet spot and works the same way, a class that includes potentially millions of antibodies."

https://www.scotusblog.com/2023/05/supreme-court-rules-invalid-amgens-patent-on-cholesterol-lowering-drug/

'Those careers are now few and far between. About 60% of life scientists who earned a Ph.D. in 1963-64 secured tenure within 10 years. But by 2021, only 3.5% of biology Ph.D.s working at universities had been tenured within a decade of graduating, according to a National Science Foundation survey.'

https://www.statnews.com/2023/06/06/postdoc-system-teetering-imperiling-life-sciences-diversity/

'Here, we summarize progress and challenges in the development of broad-spectrum antivirals that target either viral elements (proteins, genome structures, and lipid envelopes) or cellular proviral factors co-opted by multiple viruses via newly discovered compounds or repurposing of approved drugs.'
#Virology #Antiviral #drugdevelopment

https://www.jci.org/articles/view/170236

'What’s more surprising is that, of all the online search experiments that took place during this period – including commercially focused search systems like Lockheed’s Dialog, which has since become an enterprise product – SUPARS mimicked contemporary web search more closely than any other, prefiguring several primary features of web-search protocols we rely on more than 50 years later.'

https://aeon.co/essays/the-1970s-librarians-who-revolutionised-the-challenge-of-search