Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Workflow for Validating Specific Amino Acid Footprinting Reagents for Protein Higher Order Structure Elucidation | https://pubs.acs.org/doi/10.1021/acs.analchem.3c01919 #proteomics
A great week at the soon to be extinct Gulbenkian Science Institute/IGC teaching MD PhD students of the EMERALD program.
"After much effort Baudelaire breached the threshold and was able to ‘penetrate the fortifications of that studio’. While other men craved privacy for vice, he wrote, Delacroix demanded it for ‘drunken orgies of work’."
https://www.lrb.co.uk/the-paper/v45/n13/tom-stammers/we-demand-cloistersee
Adapt, improvise, overcome.
"In response to a cotton square scented with a novel neutral odor (lavender), most control mice shredded the material, built a nest, and fell asleep within 90 min."
#neuroscience #preprint
https://www.biorxiv.org/content/10.1101/2023.06.21.545975v1?med=mas
Thiago Carvalho
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Antibody There? Mapping the Human Proteome with Mathias Uhlén | GEN Biotechnology https://www.liebertpub.com/doi/full/10.1089/genbio.2023.29099.muh #proteomics
Thiago Carvalho
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On #BreakingNews days like today (#Russia coup?) if you miss the Twitter experience of following live news, here’s a protip: I eventually figured out that following the local feed at journa.host was a pretty good substitute for breaking news coverage: journa.host/public/local
“I’m sure Earth can’t wait to be exclusively under Zuck’s thumb with no other options,” remarked Musk , who presumably sees himself as Earth’s other option. I know what you’re thinking – it’s not just that our species has no dignity. It’s that it has no path to dignity.'
Thiago Carvalho
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Mathematician, computer scientist, and WWII code breaker Alan Turing, who established the theoretical foundation for just about every modern computing device, was born #OTD in 1912. His work helped make it possible for you to read this.
The British government prosecuted him for being gay, a monstrous act that eventually led to Turing’s death by suicide. Then they waited 50 years before issuing a pardon.
Image: The Guardian
Progress on understanding #endometriosis
"In a cohort of women, 64% of patients with endometriosis but <10% of controls were found to have Fusobacterium infiltration in the endometrium. Immunohistochemical and biochemical analyses revealed that activated transforming growth factor–β (TGF-β) signaling resulting from Fusobacterium infection of endometrial cells led to the transition from quiescent fibroblasts to transgelin (TAGLN)–positive myofibroblasts, which gained the ability to proliferate, adhere, and migrate in vitro."
#HostPathogen
A great piece on Daniel Ellsberg
“You don’t want on this jury men of middle age,” advised a psychologist retained by the team that defended Ellsberg and his collaborator Tony Russo for leaking the Papers. “These are people who in the course of their lives might possibly have sacrificed principle for the sake of career, for the sake of family, and they lived with that compromise, and they will have a lot of disdain, even contempt for two men who did it for the sake of principle and took the risk.”
https://thebaffler.com/latest/daniel-in-the-lions-den-baker?ref=thebrowser.com
“Overall, this paper shows for the first time a unique population of macrophages that emerges specifically during lactation and is of interest to immunologists, particularly macrophage biologists."
Thiago Carvalho
boosted
How spontaneous and forced walking and turning affect neural activity in the drosophila brain. https://elifesciences.org/articles/85202?utm_source=mastodon&utm_medium=social&utm_campaign=organic
An off-the-shelf CART story at NEJM.
"And at the same time, we’re now tackling a different type of leukemia, T-cell leukemia. So in combination, three editing steps to remove molecules on the surface of T cells to allow them to be used off the shelf and to be able to have those cells ready, premanufactured and frozen, and to be able to give them in a timed way to patients who otherwise would not have treatment options."
#immunotherapy #Immunology #Hematology #Leukemia
https://www.nejm.org/doi/full/10.1056/NEJMp2303851?query=featured_home
Thiago Carvalho
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New article! Read Globally invariant behavior of oncogenes and random genes at population but not at single cell level https://www.nature.com/articles/s41540-023-00290-9?utm_source=dlvr.it&utm_medium=mastodon in npj SBA
"After leaving the field in disgrace, Dr. Hwang has landed in clover, and now spends his days cloning beauty show and racing camels for United Arab Emirates royalty."
https://www.nytimes.com/2023/06/21/opinion/cloning-science-fraud.html
Thiago Carvalho
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'Here, we aimed to understand how closely related strains with overlapping metabolic capacities can co-bloom (i.e., both strains reaching high densities) in the mammalian gut and how this promotes the spread of antibiotic resistance plasmids.'
#HostPathogen #microbiology #mucosalimmunology
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00222-6
Boehringer moves forward with its glucagon/GLP-1 receptor dual agonist, survodutide.
"The German drugmaker is now preparing to launch a late-stage trial of its drug, which if approved, would compete with Eli Lilly’s Mounjaro and Novo Nordisk’s Wegovy. US pharma group Pfizer and biotech Regeneron are among the others hoping to enter the market."
#Metabolism #Pharma #DrugDevelopment #DrugDiscovery #Obesity
https://www.ft.com/content/d3f5e936-05af-4775-8247-cff1c007ba45
'Nos últimos 17 anos, Portugal enviou 309,6 milhões de euros para Universidade Carnegie Mellon, o Instituto de Tecnologia do Massachusetts (MIT) e a Universidade do Texas em Austin, contou António Sousa Pereira, explicando que as transferências se inserem numa parceria lançada entre 2006 e 2007, através da Fundação para a Ciência e a Tecnologia (FCT).'
Thiago Carvalho
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"On being asked what made the LMB such a remarkable place, Max answered: ‘Creativity in science, as in art [referring to the Renaissance in Florence], cannot be organised. It arises spontaneously from individual talent. Well-run laboratories can foster it, but hierarchical organisations, inflexible bureaucratic rules, and mountains of futile paperwork can kill it. Discoveries cannot be planned, they pop up, like Puck, in unexpected corners.’"
From Daniela Rhodes' 2002 piece on #MaxPerutz
https://www.embopress.org/doi/full/10.1093/embo-reports/kvf103
Thiago Carvalho
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Local enhancers of the #PAIR4 regulatory module promote distal V-H gene #recombination at the #Igh locus and contribute to #Bcell receptor repertoire diversification
Louisa Hil et al Busslinger lab @IMPvienna
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
