'The world has baked for 12 consecutive months in temperatures 1.5C (2.7F) greater than their average before the fossil fuel era, new data shows.
Temperatures between July 2023 and June 2024 were the highest on record, scientists found, creating a year-long stretch in which the Earth was 1.64C hotter than in preindustrial times.'
https://www.theguardian.com/environment/article/2024/jul/08/temperatures-1-point-5c-above-pre-industrial-era-average-for-12-months-data-shows
It appears that the #Project2025 document available online has been edited. It still appears to be 922 pages and has the same contents page as before, but the material has been moved around so it no longer lines up with the content page and it's hard to search. I haven't determined how else it was changed.
'For decades, Africa has been a pivotal site for global research and discovery, significantly contributing to advancements across various fields. However, this role has occasionally led to exploitative practices, prompting a significant reevaluation of ethical research standards. This concern has highlighted the need for stringent ethical practices in collaborations between African researchers and their collaborating partners. To address these issues, specific local ethical standards and guidelines have been developed to ensure responsible research practices within Africa. These guidelines are designed to be rigorously adhered to by all researchers, including both local and international collaborators, to foster a culture of integrity and respect in research.'
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012197
'Even without exposure to antigens, some CARs increase proliferation and nutrient uptake in T cells. Using stable isotope tracers and mass spectrometry, we observed basal metabolic fluxes through glycolysis doubling and amino acid uptake overtaking anaplerosis in CAR-T cells harbouring a rituximab scFv, unlike other similar anti-CD20 scFvs.'
#Immunology #Immunotherapy #CARTcells
https://www.nature.com/articles/s42255-024-01034-7
'Here, we present proof-of-concept that a logistic regression model is capable of differentiating between three paradigmatic lymphomas—nodular lymphocyte predominant B cell lymphomas (NLPBL), diffuse large B cell lymphoma (DLBCL), and chronic lymphocytic leukemia (CLL).'
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011570
'In this instalment of the series Great Art Explained, the UK curator, gallerist and video essayist James Payne details why, even as nudity was prevalent in the art of Manet’s era, the depictions of naked women in his paintings were radical for their unidealised style – and for the way they stare directly at the viewer, daring, per Payne, to defy the male gaze.'
'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext
'When Steve was around 10, a doctor informed him and my parents that he most likely had a genetic disorder called Marfan syndrome. Suddenly, the idea of physical normalcy became deeply and personally relevant. My brother’s life story had converged with the story of genetic medicine.'
https://theamericanscholar.org/imperfecta-2/
OECD: Germany gets top marks on integration
A new OECD study has found Germany is successfully integrating migrants despite obstacles such as migrants often having little education.
https://www.dw.com/en/oecd-germany-gets-top-marks-on-integration/a-69584486
'An entire set of Hiroshige’s colorful depictions of his native city was bound into a book, donated to the Brooklyn Museum and left in storage for 40 years before being unbound in the 1970s. Because it was probably intended especially for such a collection, this particular set was also a kind of luxury edition, made with extra care and details, like the use of reflective metallic dust, that ordinary consumer-grade prints, for all their intricacy, didn’t have.'
https://www.nytimes.com/2024/07/04/arts/design/hiroshige-art-brooklyn-museum-woodblock.html
France no longer resembles a divided but tolerant family. It is catastrophically fractured | Andrew Hussey
https://www.theguardian.com/commentisfree/article/2024/jul/07/france-elections-far-right
'Myeloid-derived suppressor cells (MDSCs) could differentiate into functional osteoclasts. Moreover, B cells, especially switched memory B cells, could promote the osteoclastogenic potential of MDSCs in rheumatoid arthritis'
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202350823
'Para que isso aconteça, o exemplo da Frente Popular original é ainda o melhor guia. É o foco no bem-estar das pessoas, na qualidade de vida e na capacidade de os empregados e trabalhadores terem rendimento suficiente para terem uma vida digna e confortável que terão de estar os objetivos que permitirão afastar a França do abismo de um colapso do Estado de direito, da democracia e dos direitos fundamentais.'
@ruitavares
https://expresso.pt/opiniao/2024-07-04-a-franca-frente-a-frente-71652e29
'In this instalment of the series Great Art Explained, the UK curator, gallerist and video essayist James Payne details why, even as nudity was prevalent in the art of Manet’s era, the depictions of naked women in his paintings were radical for their unidealised style – and for the way they stare directly at the viewer, daring, per Payne, to defy the male gaze.'
Coordinator, Clinical & Translational Collaborations
Cold Spring Harbor Laboratory
See the full job description on jobRxiv: https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-coordinator-clinical-translational-collaborations/?feed_id=77496
#ScienceJobs #hiring #research
https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-coordinator-clinical-translational-collaborations/?feed_id=77496
Researchers generate heat exceeding 1,800 degrees using incredible solar thermal trapping method: 'This is crucial'.
It takes a lot of heat, mostly from fossil fuels, to make steel, glass, ceramics, cement; ~ 25% of global energy consumption. Scientists in Zurich are using synthetic quartz to trap heat from the sun at temperatures > 1,000 C. Previously, solar heat could only be trapped up to about 170 C. The much higher heat can be used to smelt steel and cook cement.
https://www.thecooldown.com/green-tech/solar-heat-smelting-industry-eth-zurich/
UNESCO online event Wednesday, July 10 to announce the Global Diamond Open Access Alliance.
https://scienceeurope.org/events/announcing-the-global-diamond-open-access-alliance/
Date: 10th July 2024
Time: 15:00 – 16:10 CET / 9:00 - 10:10 am Eastern / 6:00 - 7:10 a.m. Pacific
Venue: Online
Registration link: https://shorturl.at/lZnyh
'In 1999, Haynes and team demonstrated that HIV-1–infected patients with myasthenia gravis who underwent thymus removal still experienced peripheral CD4+ T cell rises following ART, demonstrating that peripheral T cells were primarily responsible for blood T cell reconstitution in those individuals'
https://www.jci.org/articles/view/183039#B1
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com