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'We observed that multiple aspects of science identity were positively impacted by participation in the mentorship program, including mentees’ sense of belonging to the community of scientists (80%), feeling that their identity and background are welcomed in their academic program (88%), feeling like they belong in science (90%), their perception of the daily work of scientists (83%), sense of value as a scientist because of their identity and background (71%), and certainty of their place in science (68%).'

biorxiv.org/content/10.1101/20

'A play, Kyoto — which had its world premiere last month at the Royal Shakespeare Company’s Swan Theatre in Stratford-upon-Avon, UK — attempts to cast a fresh light on climate narratives by focusing on the negotiations of the Kyoto Protocol. This international treaty, signed on 11 December 1997 in Kyoto, Japan, was the first to commit countries to reduce their greenhouse-gas emissions to mitigate climate change.'

nature.com/articles/d41586-024

'Here, we developed a multi-tumor mouse model system to track hundreds of expanding and contracting CD8+ T cell clones over multiple timepoints in tumors of the same individual. Through coupling of clonal expansion dynamics and single-cell RNA/TCR-seq data, we identified a transcriptomic signature in PD-1+Ly108+ precursor exhausted cells that strongly predicts rates of intratumoral clone expansion in mice and humans.'

biorxiv.org/content/10.1101/20

'The results of these efforts were extraordinary, however. The images revealed jumping spiders, weevils, dragonfly nymphs, and myriad other arthropods in exquisite detail, from an unprecedentedly personal perspective.'

publicdomainreview.org/collect

'Neste aspeto, a Fundação para a Ciência e a Tecnologia (FCT) e os diferentes ministros que a têm tutelado adicionam à sua já conhecida incompetência uns laivos de crueldade, uma vez que nem dão estabilidade laboral aos investigadores, nem lhes dizem o que têm de fazer para a obter. Os investigadores vivem com o credo na boca, impossibilitados de fazer planos de vida além de seis anos ou a fazê-los por sua conta e risco, confiando não no seu trabalho e mérito individual, mas na sorte de serem selecionados num qualquer concurso.'

publico.pt/2024/07/11/ciencia/

'It would be easier to run sensible immigration policy with EU freedom of movement. Better to have migrants with good employment rights who can respond to shifting demand by switching employers and moving back and forth from the UK rather than vulnerable workers trapped by company- or sector-specific visas. It’s unlikely the UK would be flooded with cheap European labour: incomes in central and eastern European countries have rapidly converged with those in western Europe. But anything related to the EU and free movement of workers remains toxic. Depressingly, Labour this year ruled out the European Commission’s suggestion of an EU-UK youth mobility scheme.'

ft.com/content/a0e9fe66-5ca1-4

I'm trying to finish up everything before my holiday starts next week, but the #SeaIce is continuing to break up so now we have to organise collection of the buoys probabaly within the next couple of weeks.

Unfortunately, it's pretty cloudy right now, and we seem to be missing some sentinel1 scenes, so we're very much relying on our local collaborators to judge
Update on latest post:
sternaparadisaea.net/2024/07/0

'The tool — a type of ‘base editor’ — modified the target gene in more than 90% of an Escherichia coli colony inside the mouse gut. “We were dreaming of being able to do that,” says Xavier Duportet, a synthetic biologist who co-founded Eligo Bioscience, a biotechnology company in Paris. The findings were published today in Nature.'

nature.com/articles/d41586-024

'The findings suggest that i) the Romans most likely discovered the islands around the 1st century BCE; ii) Berber groups from western North Africa first set foot on one of the islands closest to the African mainland sometime between the 1st and 3rd centuries CE; iii) Roman and Berber societies did not live simultaneously in the Canary Islands; and iv) the Berber people rapidly spread throughout the archipelago.'

pnas.org/doi/10.1073/pnas.2302

Priming lymphocyte responsiveness and differential T cell signaling in pediatric IBD patients with Cannabis use. biorxiv.org/content/10.1101/20

'Patients develop T cell lymphomas after CAR-T therapy extremely rarely — less than 0.1% of the time, Rejeski said. Second cancers also rarely cause death in CAR-T patients, Rejeski said. Mortality from these subsequent cancers occurs roughly 0.5% of the time. In comparison, infections led to the deaths of about 4% of CAR-T patients in a study that Rejeski published in Nature Medicine this week. “Infections, infections, infections. This is the main driver of non-relapse mortality,” he said.'

statnews.com/2024/07/12/cancer

Host-use Drives Convergent Evolution in Clownfish and Disentangles the Mystery of an Iconic Adaptive Radiation biorxiv.org/content/10.1101/20

Abstract submission now open for the 2024 online Big Team Science conference! @btscon.bsky.social

bigteamscienceconference.githu

#metascience We (contributorshipcollaboration.g , neuromatch.social/@tenzingCont) are working on a hackathon proposal ,"Helping big teams give more CRediT to their contributors" :)

Gen X seems to have a higher cancer risk than older generations. Here are some disturbing graphics and the latest ideas about what could be contributing to this trend scientificamerican.com/article

'These studies have helped to answer “some of the questions that were precipitated by the FDA announcement,” Maus said. They still have not found definitive evidence that CAR-T therapy has directly caused new cancers, she said, and scientists continue to suspect that such an event would be extremely rare.'

statnews.com/2024/07/12/cancer

'The problem is not that young people are eco-anxious. It's that people in positions of power are not'

Climate activist Clover Hogan founded non-profit Force of Nature to help young people turn feelings of climate anxiety into action. She says that climate anxiety is not a negative phenomenon, rather a healthy psychological response. It is evidence that “we’re awake in a culture that tries to numb us and switch us off from the climate crisis.”

naturahoy.com/2024/07/the-prob

#environment #climate

Cytosol-living Trypanosoma cruzi amastigotes scavenge cholesterol from host ER and Golgi complex biorxiv.org/content/10.1101/20

Amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial function biorxiv.org/content/10.1101/20

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