'But vaccines don’t save lives on their own. Vaccinations do. People have to actually get the vaccine for the magic—OK, the biology—to happen. And we need as many vaccinations as possible to make sure we can protect even those who may not be vaccinated by the virtue of herd immunity, in which we cut off chains of transmission in our communities.'
https://www.thenation.com/article/society/vaccines-work/
High-speed train from Paris to Berlin to launch this winter with daily connections from €59
The route will include stops in three German cities.
Elon Musk Throws Tech Tantrum Over 'Swindler of the Century'
https://www.thedailybeast.com/musk-lambastes-sam-altman-as-openai-weighs-for-profit-pivot
Toward a Radically Simple Multi-Modal Nasal Spray for Preventing Respiratory Infections
An potentially elegant way to reduce pathogens and allergens?
https://onlinelibrary.wiley.com/doi/10.1002/adma.202406348
1/7
'This and other research pushed him to conclude that “every cell is a special snowflake”. And that conclusion significantly complicated his research into how some cancer cells develop resistance to drugs. For Buenrostro, now at Harvard University in Cambridge, Massachusetts, it meant that “all of these snowflake cells can actually be important”
https://www.nature.com/articles/d41586-024-03073-2
'They say that there is at least one clinical trial underway with a BeiGene BTK degrader (BGB-16673) that "incorporates and/or is derived from AbbVie’s BTK degrader trade secrets and confidential information that BeiGene enticed and encouraged Liu to use and disclose to BeiGene".
https://www.science.org/content/blog-post/stealing-protein-degrader-secrets
'Wellcome intends to fund consortia that develop data platforms and tools that help to reach that point. This is “an unusual play from Wellcome”, says Tariq Khokhar, head of data for science and health at the charity. The organization is known for funding health research, but this money could help to make sense of evidence across any discipline. “This is really a foundation for anyone to build on,” he says.'
Assessment of drive efficiency and resistance allele formation of a homing gene drive in the mosquito Aedes aegypti https://www.biorxiv.org/content/10.1101/2024.09.24.614707v1?med=mas
'This week Tisile will support fellow activists lobbying a high-level UN meeting on tackling drug resistance, a global scourge that is alarming health experts, governments and the private sector. TB is central to this potentially catastrophic pharmaceutical failure, which means tackling it is crucial to averting what has been branded a “silent pandemic”.
#Tuberculosis #PublicHealth
https://www.ft.com/content/00d5e030-894b-443b-b3ac-375dd530273d
'For the first time, we are now starting to build a picture of how this resistance is affecting people’s care. The Lancet recently published new research from the Global Research on Antimicrobial Resistance (Gram) Project, which revealed deaths directly attributable to bacterial AMR are continuing to rise. This might be a surprise to some, as we would expect the incredible progress we’ve made in reducing infection over recent decades to limit deaths from AMR. Nevertheless, the new analysis using records dating back to 1990 found that over a million lives have been lost to AMR every year, adding up to more than 36 million – and these numbers are on the rise.'
'According to the climate scientist Carlos Nobre, if the country continues down its current path of mining and agribusiness, aided and abetted by high finance in São Paulo and politicians at every level from the federal to the local, most of Brazil’s cities could be uninhabitable by 2050.'
'On Sept. 15 on “Meet the Press,” Vance — after noting that people in good health have very different needs from those with chronic conditions — called for deregulation, saying that we should “promote some more choice in our health care system and not have a one-size-fits-all approach that puts a lot of people into the same insurance pools, into the same risk pools.”
https://www.nytimes.com/2024/09/23/opinion/trump-vance-obamacare-concepts.html
'Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α, -β, and/or -ω can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition.'
'Euripides is the best represented of the Greek tragedians, which would have annoyed his contemporaries. He was lampooned in his day for his novel sonic effects, his corruption of Athenian values and his penchant for female protagonists and characters dressed in rags – an innovator, according to his critics, but not necessarily in a good way. In the end, he got the last laugh.'
https://www.lrb.co.uk/the-paper/v46/n18/robert-cioffi/euripides-unbound
Can't believe I had to write this. But given the upswing in anti-vax sentiment in the US and the low vaccination rates for COVID and flu (and the under-vaccination of kids for some infections), it has to be said loud and clear. Vaccines work. Get yours today. https://www.thenation.com/article/society/vaccines-work/
Evolvoid: A genetic algorithm for shaping optimal cellular constructs https://www.biorxiv.org/content/10.1101/2024.09.24.614676v1?med=mas
Characterisation of Gas Vesicles as Cavitation Nuclei for Ultrasound Therapy using Passive Acoustic Mapping https://www.biorxiv.org/content/10.1101/2024.09.24.614126v1?med=mas
'But vaccines don’t save lives on their own. Vaccinations do. People have to actually get the vaccine for the magic—OK, the biology—to happen. And we need as many vaccinations as possible to make sure we can protect even those who may not be vaccinated by the virtue of herd immunity, in which we cut off chains of transmission in our communities.'
https://www.thenation.com/article/society/vaccines-work/
Evolution of transcription factor-containing superfamilies in Eukaryotes https://www.biorxiv.org/content/10.1101/2024.09.24.614687v1?med=mas
'Hobsbawm is also brilliant in connecting political developments to those in other domains, making small points of data into powerful observations. To mark the changes in science, he notes that the total number of German and British chemists in 1910 was 8,000. By the 1980s the number of people employed in scientific research surpassed five million.'
https://newrepublic.com/article/184512/eric-hobsbawms-lament-twentieth-century
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com