Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
https://www.biologists.com/meetings/dmminfectious2023/
Excited to promote this meeting in London - Infectious Diseases through an Evolutionary Lens - in October 2023. Diverse topics, speakers and perspectives. Organized with Wendy Barclay, Sara Cherry and Russell Vance.
Thiago Carvalho
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This paper has not gotten enough attention! We are moving towards large-scale genomics. They reannotated 488 genomes in a comparatve way!
"TOGA integrates gene annotation with orthology inference at scale"
https://www.biorxiv.org/content/10.1101/2022.09.08.507143v1
We know phylogenomics can suffer from bias by annotation method: https://pubmed.ncbi.nlm.nih.gov/35588743/
I'm working on a similar solution, but only 283 genomes to start. Now I've got something to compare to. Mine will be a bit more #Rust-y, though.The possibilities are exciting.
Thiago Carvalho
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Essential reading for anyone studying bacterial pathogens:
Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
"Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa—were responsible for 54·9% (52·9–56·9) of deaths among the investigated bacteria."
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02185-7/fulltext#%20
HT @onisillos
"Should this framework be correct, the extensive ongoing efforts devoted to targeting amygdala circuits and rodent behaviors such as freezing and avoidance are unlikely to provide a direct route to treatments for human fear and anxiety disorders. These lines of research can help, but not without recognizing the centrality of subjective experience."
@NicoleCRust & Joseph E.LeDoux, 'The tricky business of defining brain functions' @TrendsNeuro
https://www.sciencedirect.com/science/article/pii/S0166223622002132?dgcid=author
Thiago Carvalho
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Defining brain functions is a top-4 challenge for brain research. Conversations with my co-author @amygdaloid have made me realize why. Among the big topics, I suspect that it's the most underappreciated.
Why does it matter? We summarize it here (share link):
https://authors.elsevier.com/a/1g7ZrbotpyLNK
Thiago Carvalho
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Thiago Carvalho
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With #TwitterMeltdown continues, our lab is looking for a RA. Please DM or rios@hku.hk
We have one project with exciting data open for you
#HKU #CellFate #Epigenome #Myeloid #Development
Thiago Carvalho
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Time for my #introduction ! I’m an Assistant Professor at the Institute of Microbiology and Infection, University of Birmingham. Me and my team study #AMR in G-ves, mostly E. Coli & #Klebsiella. We look at plasmid mediated AMR such as #ESBLs and carbapenamases, understanding their fundamental biology and looking at how we can stop them! Still learning this platform!
Thiago Carvalho
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Hello #sciencemastodon - we'll be posting our news and updates here and on our Twitter account (@AnnualReviews).
Thiago Carvalho
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The first black child ever allowed to attend a white school is only 68 years old now.
White parents pulled their children from school. White teachers refused to teach her.
Ruby Bridges now works as an activist & public speaker
This wasn’t a million years ago. /1
Not good news on the clinically available monoclonals vs newer covid lineages.
"Our data reveal that emerging omicron sublineages are resistant to most (ie, BA.4.6, BA.2.75.2, and BJ.1) or all (BQ.1.1) clinically used mAbs. As a consequence, in patients at high risk, treatment with mAbs alone might not provide a therapeutic benefit in regions of the globe in which BQ.1.1 is spreading, suggesting that additional treatment options (eg, paxlovid or molnupiravir) should be considered. Furthermore, novel, broadly active mAbs are urgently needed for prophylactic or therapeutic treatment, or both, in patients at high risk."
#COVID #Antibody #MonoclonalAntibody
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00733-2/fulltext
Thiago Carvalho
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🇫🇷 French media regulator asked Twitter to explain how it will respect the law on hate speech and misinformation now that most of its moderators are gone. Twitter has until Thursday to answer.
Thiago Carvalho
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RT @florianjug@twitter.com
🚨Job Alert 🚨
We are looking for a #BioimageAnalyst and/or #RSE to join our growing image analysis facility here at Human Technopole in the beautiful city of Milan, Italy.
#Apply before December 16!
https://forum.image.sc/t/job-opportunity-bioimage-analyst-and-research-software-engineer/74182
🐦🔗: https://twitter.com/florianjug/status/1594720930907185152
Thiago Carvalho
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#Introduction: I'm a Research Fellow at NCI/NIH and AMNH studying #VirusEvolution.
My main project investigates #HPV and #CervicalCancer.
Other scientific interests include #MolecularEvolution, #PopulationGenetics, #mutation, #SARSCoV2, #OverlappingGenes, and #bioinformatics methods.
When I'm not coding I'm #weightlifting, #reading, #singing, or drinking #coffee.
So excited to be part of this community!
Thiago Carvalho
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Beautiful #cryoET paper on choanoflagellate #flagella #cilia revealing the enigmatic ciliary vane, new components and similarities to animal cilia
#protist #evolution #EM #choanoflagellate
https://elifesciences.org/articles/78133
Thiago Carvalho
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"Living with viruses should mean embracing simple public health measures rather than learning to live with staggering levels of illness and death. "
https://qoto.org/@cyrilpedia/109387587607038029
"Untangling such interference hasn’t been easy given the number of respiratory viruses—coronaviruses, rhinoviruses, adenoviruses, RSV, and influenza are just among the best known—and the many infections that escape notice. Recent advances in technology, however, make it easier to detect infections in people and study how multiple viruses behave in the lab, in cell cultures or stem cell–derived tissues known as organoids. Increasingly, researchers are fingering a cause: chemical messengers that infected people produce called, fittingly, interferons."
"A storm of these proportions should demand not only crisis clinical measures, but also community prevention efforts. Yet instead of deploying public health strategies to weather the storm, the U.S. is abandoning them."
#Flu #RSV #Covid #publichealth
https://www.statnews.com/2022/11/22/tripledemic-hurricane-include-community-prevention-efforts/
Thiago Carvalho
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Haaretz editorial: A Convicted Criminal as Israel’s Super Police Chief
“…not just a blow against the separation of powers but a serious danger to the rights of Israel’s Arab citizens….the fact that it will be in the hands of a pyromaniac like Ben-Gvir only magnifies the danger.”
Thiago Carvalho
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That's embarrassing. Marcel Levi, the president of Dutch science funding agency NWO, wrote a newspaper column ridiculing the concept of social safety at work as a "meaningless buzzword" and said people use it just to get a new desk chair or a faster computer.
The Dutch academic community, still reeling from a major misbehavior case, was aghast; five days later, Levi was upbraided by his own Executive Board and apologized profusely. https://www.nwo.nl/en/news/marcel-levi-social-safety-paramount-importance-academia
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
