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Thiago Carvalho boosted
CrisBonorino

Fantastic paper from Thiago Cunha and gang implicating IDO producing meningeal dendritic cells in neuropathic pain. Congrats, guys! jci.org/articles/view/153805

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Thiago Carvalho

Gathering real world data on the efficacy of drugs and vaccines used to treat or prevent is vital. Many where developed for and approved via the FDA's "animal rule", which means that although the safety data is there, the efficacy is essentially unknown. I wrote a bit about this for in September when looking at the use of the for monkeypox.

nature.com/articles/d41591-022

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Thiago Carvalho

'During the current outbreak of (recently renamed mpox), has been recommended to prevent mpox infection in persons who have had mpox exposure, but evidence to support this practice is limited.1,2 We conducted a study to evaluate potential breakthrough infections in participants who had received smallpox vaccine after high-risk exposure to mpox.'

nejm.org/doi/full/10.1056/NEJM

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Thiago Carvalho boosted
Development

In preprints: improving and interrogating embryo models

Antonio Scialdone and Nicolas Rivron discuss the fast developing field of embryo models, highlighting two preprints with new methods for ensuring reproducibility and investigating complexity.

journals.biologists.com/dev/ar

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Thiago Carvalho

"A better understanding of the relative contribution of IFN-γ–dependent and –independent pathways in resistance to is needed, and understanding which immune deficiencies lead to increased risk for cryptosporidiosis may offer clues as to the host pathways that restrict Cryptosporidium that may also be relevant to other enteric pathogens."

journals.aai.org/jimmunol/arti

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Thiago Carvalho boosted
antica_c

Why dont researchers use Open Data? One of the reasons: dont know how to find them

Help us change this by adding resources to (or using) EcoEvo catalogue ckan-ecoevo.d4science.org/ It lists aggregators you can use to find data, like WoS finds articles

more details on data reuse in doi.org/10.1038/s41559-017-045

I would also love to hear from you. Do you find this resource useful? Why yes, why not? Would you like to do some further research on data finding with me? How can we improve the catalogue?

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Thiago Carvalho boosted
Max Delbrück Center

A little late, but here's our #introduction:

We are a research institute devoted to biomedical research. Our aim is to understand the molecular basis of health and disease - and to translate findings as quickly as possible into clinical applications. Better prevention, diagnosis and treatment of diseases are the ultimate goals.

#Genes
#Cells
#Molecules
#Proteins
#SystemsMedicine
#Cardio
#Biomedicine
#Diseases
#Health

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Thiago Carvalho

'One answer is that as a country, we prefer just to not see those deaths at all, regarding a baseline of several hundred deaths a day as a sort of background noise or morbid but faded wallpaper. We don’t need to understand who is dying or why in part because we don’t want to reckon with the fact that around 300 Americans are now dying from Covid-19 every day, at a rough pace of about 100,000 per year, making it the country’s third leading cause of death. This is normalization at work, but it is also a familiar pattern: We don’t exactly track the ups and downs of cancer or heart disease either.'

nytimes.com/2022/12/07/opinion

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Thiago Carvalho boosted
Ivan Scotti

When asked by the occasional layperson whether there are everyday consequences of population-genetic processes, this paper may come handy to support one's answer

nature.com/articles/s41586-022

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Thiago Carvalho boosted
Thiago Carvalho

Thirty years ago, in November 1992, Ishida, Honjo and their collaborators reported the discovery of the gene in @embojournal

embopress.org/doi/abs/10.1002/

I spoke with Tasuku Honjo, Pierre Golstein (whose team first cloned ) & Facundo Batista about the discovery earlier this year.
The initial project had absolutely nothing to do with checkpoints or

Listen to the full episode at the link below or on pretty much any podcast app

embo.org/podcasts/from-cell-de

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Thiago Carvalho

'Prosecutors described Balwani as an “equal participant” in helping Theranos defraud investors of more than $900mn in funding — which gave the company a valuation of $9bn — on the promise its technology could carry out a range of tests on a single drop of blood.

Instead, the machines failed to perform as promised, as later revealed by whistleblowers, and the company entered a death spiral that has become symbolic of Silicon Valley’s risk-taking culture.'

ft.com/content/c456dfb5-34d2-4

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Thiago Carvalho boosted
Salva Iborra Lab

RT @ScheiermannLab@twitter.com

Tumor growth is governed by the time of engraftment, which is controlled by the adaptive immune system; have a look at our circadian anti-tumor immune response paper: nature.com/articles/s41586-022

🐦🔗: twitter.com/ScheiermannLab/sta

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Thiago Carvalho boosted
Darren Obbard is on Bluesky

Day8: Lordiphosa andalusiaca—Our first #Advent species not in #Drosophila: a distinctive #Fly with a striking colour #polymorphism (brill.com/view/journals/anz/17 - ours is a dark one). Lordiphosa like rotting plants drosophila.jp/jdd/class/030704 and some species have sex combs doi.org/10.1111/evo.14564 . It gives us two lessons in systematics: [1] #Drosophilid #Taxonomy doesn’t match #Phylogeny academic.oup.com/gbe/article/1 ; [2] Do not let people play word games with your (sub)genera... cf. Phloridosa & Siphlodora

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Thiago Carvalho boosted
Akos T Kovacs

RT @CarstenWMueller
10 days to go - PostDoc and PhD position in our #SoilScience group at @science_ku - work with us on #RootCarbon #RhizosphereFunctioning #Imaging #POM #MAOM #SoilCarbonStorage #RootTraits apply online:
PostDoc: employment.ku.dk/all-vacancies
PhD: employment.ku.dk/all-vacancies @novonordiskfond

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Thiago Carvalho

'The lack of doctors entering ID fellowships — and the ensuing shortage of these specialists — has been a concern for years, with experts pointing to the comparatively low earnings these physicians make as a major disincentive for doctors considering which field to enter. But this year’s numbers marked a backslide. Fully a quarter of available positions went unfilled. Among the fellowship programs, 44% didn’t fill their slots, according to data from the National Resident Matching Program.'

statnews.com/2022/12/07/infect

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Thiago Carvalho boosted
James Briscoe

Really excited to launch @Dev_journal@twitter.com "Pathway to Independence Programme"

Are you, or do you know, a dev bio or stem cell researcher planning to apply for their 1st PI position in 2023?

Then this scheme is for you. See how to apply:

journals.biologists.com/dev/ar

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Thiago Carvalho boosted
Rio Sugimura

RT @Dev_journal@twitter.com

We're excited to announce a new scheme aimed at supporting postdocs as they go on the job market. Our 'Pathway to Independence' programme will provide mentorship, support and networking opportunities to a group of researchers transitioning to independence journals.biologists.com/dev/ar

🐦🔗: twitter.com/Dev_journal/status

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Thiago Carvalho boosted
Dan Mucida

Let’s make the science move to a definitive thing.
---
RT @cyrilpedia
The community is growing over there - I even have a range of science-Luis friends to choose from, with @lmvteixeira at

@lmvteixeira

& @LuisMateusRocha at

@lmrocha
twitter.com/CyrilPedia/status/

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Thiago Carvalho boosted
Dan Mucida

RT @francesarnold
caught up with ⁦@CarolynBertozzi⁩ and Jennifer ⁦@doudna_lab⁩ ⁦@NobelPrize⁩

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Thiago Carvalho boosted
Stephanie Nolen

So ends a historic attempt at global health equity: The board of Gavi votes this week on ending #Covax, even though some Gavi-supported countries are at <20% Covid vaccine coverage. The average among Gavi-countries is 52%. And 37 middle-income countries would be cut off after a one-time infusion of cash to take over Covid vaccination on their own. Thanks to vaccine nationalism, Omicron and a series of missteps, demand for shots globally is minimal. nytimes.com/2022/12/06/health/

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