Thiago Carvalho @cyrilpedia@qoto.org

"In the US, manufacturers can set drug prices freely. Drugs are priced primarily on the basis of what the market will bear, with no association, for example, to therapeutic value or research and development costs and with prices exceeding those of all other countries."

https://www.cell.com/cell/fulltext/S0092-8674(23)00162-9

'Given the vaccine nationalism seen during COVID-19, and that pandemic treaty negotiations are still nascent, there is a risk that governments, particularly those in high-income countries, will use advance purchase agreements to secure national supply of scarce vaccine resources during a future influenza pandemic.'

https://www.nature.com/articles/s41591-023-02340-5

A walking germinal center:

"A hyper-immune human subject was identified with a documented 18-year history of 756 immunizations to venoms spanning 2001 to 2018."
(ht @victoralab)

https://www.biorxiv.org/content/10.1101/2022.09.26.507364v2

My latest Clinical Pipeline column for #NatureMedicine, on fitusiran, a small interfering RNA for the treatment of hemophilia A or B. It may be particularly useful for patients with inhibitors (antibodies against clotting factors).

#drugdevelopment #drugdiscovery #SciComm #sciencecommunication #pharma #hemophilia 👇

https://www.nature.com/articles/d41591-023-00037-3

Very good news.

"The EU is planning a compulsory licensing system to allow it to take control of the manufacture of drugs and vaccines during a public health emergency, despite calls from pharmaceutical groups to protect patents"

https://www.ft.com/content/b777f019-ff02-41c3-8645-3d06e865f7fd

'Under pressure from their government, Chinese scientists have withheld data, withdrawn genetic sequences from public databases and altered crucial details in journal submissions. Western journal editors enabled those efforts by agreeing to those edits or withdrawing papers for murky reasons, a review by The Times of over a dozen retracted papers found.'

https://www.nytimes.com/2023/04/23/world/europe/chinese-censorship-covid.html

'Cancers that pass from one host to another are rare in nature, but can have devastating effects, says study co-author Rodrigo Hamede, a disease ecologist at the University of Tasmania in Hobart. “In a matter of 10 years, we lost between 60–70% of the overall [devil] population,” he says.'

https://www.nature.com/articles/d41586-023-01349-7

"Yet officials with the National Academies have kept quiet about one thing: their decision to accept roughly $19 million in donations from members of the Sackler family, the owners of Purdue Pharma, the maker of the drug OxyContin that is notorious for fueling the opioid epidemic."
cc @mucida

https://www.nytimes.com/2023/04/23/health/sacklers-opioids-national-academies-science.html

'Não repara quem está distraído: a extrema-direita em barda recorre aos tribunais para processar ativistas, políticos e quem se destaca no espaço público em defesa do antirracismo, da igualdade, do combate à desigualdade e do progressismo.'

https://www.publico.pt/2023/04/24/opiniao/opiniao/obrigada-francisca-van-dunem-2047212

Frogs, glazed #stoneware by @hunchbacksociety

#ceramics #ceramicart #handmade #artgallery #artmastodon

https://madalenaparreira.com/Hunchbacksociety