Thiago Carvalho @cyrilpedia@qoto.org

Lilly walks away from Nektar's PEG conjugate of rhIL-2, rezpeg - aka rezpegaldesleukin, aka NKTR-358 - after disappointing phase II results in lupus.

#Immunology #immunotherapy #RegulatoryTCell #Lupus #Treg #drugdevelopment

https://www.fiercebiotech.com/biotech/after-gathering-enough-nektar-lilly-hands-backs-rights-immunology-med-post-lupus-fail

For #throwbackthursday, a blog post from 2013 by Washington University's Joan Strassmann, on the IGC PhD course she participated in as guest faculty back when I was running the PhD program.

https://sociobiology.wordpress.com/2013/05/05/journal-club-extended-to-research-planning-for-students-at-the-gulbenkian-in-portugal/

"The rabbits’ “interracial” union had inflamed Montgomery's chapter of the White Citizens’ Council, whose members argued that the book amounted to grooming by literary means, conditioning preschoolers to cross the color line. Essentially a white-supremacist chamber of commerce, with a fast-growing network across the South in the wake of the U.S. Supreme Court’s Brown v. Board of Education desegregation decision in 1954, the council used its dollars and clout to stoke economic intimidation and violence against the burgeoning civil rights movement. These segregationists were ideological ancestors of today’s book challengers, such as those in a Florida school district that recently banned “And Tango Makes Three,” about two male chinstrap penguins who create a family. Across time, those who ban books have shared a deep aversion to anything that promotes changing definitions of marriage and family."

https://www.nytimes.com/2023/04/26/books/review/garth-williams-the-rabbits-wedding-banned-books.html

'What’s your favorite book no one else has heard of?

“The Citadel,” by A.J. Cronin, isn’t as well known in America as in Britain and the Commonwealth. The oppressive conditions described in the fictional Welsh mining town so captivated the public’s imagination that it ostensibly shares responsibility for the creation of the National Health Service. A generation of physicians outside of America name “The Citadel” as the book that called them to medicine.'

https://www.nytimes.com/2023/04/27/books/review/abraham-verghese-by-the-book-interview.html

"However, T cell responses to dietary antigen have primarily been characterized using monoclonal T cell receptor (TCR) transgenic systems which do not represent a physiological immune response. Polyclonal CD4+ T cell responses to food, including TCR-specific selection and functional differentiation, remain largely uncharacterized and are critical for understanding mechanisms of tolerance and allergy."
Lockhart, @mucida et al

#Preprint #Immunology #OralTolerance #MucosalImmunology

https://www.biorxiv.org/content/10.1101/2023.04.11.536475v1

"Map 11 The Two Ladies (Leiden, Netherlands, circa 1790)

The Two Ladies is a direct reaction to the vision of medicine put forward by the Encyclopedists, particularly in d’Alambert’s treatise on the primacy of sensory knowledge and experimentation, the Discours préliminaire. The two female figures are a not-even-thinly veiled insult directed at Diderot & d'Alembert (it was a time of rampant misogyny and Dutch humor remains to this day, as they say, no laughing matter). The image is not a map but rather a chart of sorts, with texts of Galen’s prescribed treatments overlaid on the corresponding afflicted body parts. The Margrave brought a copy of this print with him to Kaiserslautern in 1933, but it is not known if Galen’s typology of human temperament played any part in von Willebrand’s course of treatment."
#Prints #Printmaking #Print #Handmade #Maps #Cartography #artgallery #artmastodon

https://madalenaparreira.com/SPAM

' En su popularísima serie de televisión Cosmos, Carl Sagan trató la muerte de Hipatia así: “En el año 415, cuando iba a trabajar, cayó en manos de una turba fanática de feligreses de Cirilo. La arrancaron del carruaje, rompieron sus vestidos y, armados con conchas marinas, la desollaron arrancándole la carne de los huesos. Sus restos fueron quemados, sus obras destruidas”.

https://elpais.com/ideas/2023-04-27/hipatia-de-alejandria-la-pop-star-de-la-antiguedad-que-resiste-al-olvido.html