Thiago Carvalho @cyrilpedia@qoto.org

Giant neuron derived vesicles called #exophers are processed by #phagocytosis in neighboring skin cells, and the phagocytic interaction promotes exopher production. #Neuroscience https://elifesciences.org/articles/82227?utm_source=mastodon&utm_medium=social&utm_campaign=organic

During asymmetric #CellDivision of #Drosophila male #GermlineStemCells (GSCs), #histone H3 is preferentially inherited by the GSC, while H3.3 is not; @ChenLabJHU reveals that a single amino acid (A31/S31) underlies these inheritance patterns #PLOSBiology https://plos.io/4221cXG

Harnessing anti-inflammatory potential of IDO.

Exciting new approach by @keselowsky, @GregHudalla using IDO therapeutically as an anti-inflammatory . (Short 🧵 1/5)

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase

https://www.nature.com/articles/s41551-023-01025-1

Key advance:

Generating an IDO-Gal3 fusion protein.

Gal3 binds to fly and in the extracellular matrix (ECM) of tissues, anchoring IDO in place at the site of inflammation - very clever IMHO. (2/5)

In this case, the 'in mice' tag may be a plus - getting a xenograft to take in immunocompetent hosts is a high bar.

'We report the editing of primary human islet cells to the hypoimmune HLA class I– and class II–negative and CD47-overexpressing phenotype and their reaggregation into human HIP pseudoislets (p-islets). Human HIP p-islets were shown to survive, engraft, and ameliorate diabetes in immunocompetent, allogeneic, diabetic humanized mice'

https://www.science.org/doi/10.1126/scitranslmed.adg5794?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial

Today I learned the word ‘scientist’ was coined in 1834 to describe Mary Somerville, replacing the term ‘man of science’.

#science #WomenInSTEM

https://www.themarginalian.org/2016/12/26/mary-somerville-scientist/

'While we have focused on mice, it should be noted that rats may be advantageous in some circumstances. For example, while nearly all mouse models of breast cancer are estrogen-receptor negative, treatment of rats with the carcinogen N-nitrosomethylurea generates mammary tumors that are estrogen-receptor positive.'

https://www.cell.com/cell/fulltext/S0092-8674(23)00169-1

For the long weekend.

#Mitochondria, powerhouse of the #cell were labeled (cyan) and it's possible to visualize how they reach every corner.

All recorded under the microscope by @KuxJohan & @Marie_Adler23 @cellcommlab

#scicomm #microscopy @focalplane_jcs @Mito_News @MitoAging

The Mighty Krug-Man! #krugman #PaulKrugman

Former politicians and officials who supported the interests of the wealthy find comfortable sinecures at billionaire-supported lobbying firms, think tanks and media organizations. These organizations also help shape what military analysts call the “information space,” defining public discourse in ways that favor the interests of the superrich.

https://www.nytimes.com/2023/04/17/opinion/plutocrats-power-trump.html

Research technician @SanghviLab

https://jobrxiv.org/job/columbia-university-27778-research-technician/?feed_id=44232

#ScienceJobs #job
New York city #UnitedStatesUS #ResearchTechnician
https://jobrxiv.org/job/columbia-university-27778-research-technician/?feed_id=44232

Issue 9 with spotlight on actin:
- Cover on actin remodeling function of plant ribonucleoprotein assemblies
- Regulation of branched vs. linear filaments
- Monomer recycling as determinant of network turnover

Further:
Uptake-independent macrophage killing by Mtb aggregates
How cells coordinate growth with DNA replication and mitosis

https://www.embopress.org/toc/14602075/2023/42/9

First #preLight post from Aniruddha Das.

👉 https://prelights.biologists.com/highlights/proteasomeid-quantitative-mapping-of-proteasome-interactomes-and-substrates-for-in-vitro-and-in-vivo-studies/

Aniruddha picked a #preprint from the #AOri_lab and team in which proximity labelling is used to identify interactions between the #proteasome and membrane-associated proteins or transcription factors.

'In Finland and Portugal, early career academics seem to require more time on teaching than senior staff. In Norway, the opposite applies, early career academic roles list more research related criteria.'

https://blogs.lse.ac.uk/impactofsocialsciences/2023/02/13/what-40000-job-adverts-say-about-academic-career-progression/

A CRISPR atlas of human CD8 cells.

"We developed pooled CRISPR screening approaches with compact epigenome editors to systematically profile the effects of activation and repression of 120 transcription factors and epigenetic modifiers on human CD8+ T cell state."
#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2023.05.01.538906v1?med=mas