Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
I wrote about RSV vaccines in my #NatureMedicine column in February.
Very good news this week with the FDA approval of GSK's RSV vaccine for adults 60 and over - it's the first approved RSV vaccine.
https://edition.cnn.com/2023/05/03/health/first-rsv-vaccine-approved/index.html
Several other candidate RSV vaccines are at a late stage of development, including mRNA based vaccines. The next big thing to watch for are those seeking to protect newborns and infants by maternal immunisation.
#RSV #Vaccine #RespiratoryVirus #drugdevelopment #Pharma #Immunology
Thiago Carvalho
boosted
'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al
Thiago Carvalho
boosted
@mucida The paper also has a very interesting evolutionary scenario
"Unbiased phylogenetic analyses indicated that this family and its receptors28 share greater sequence/structure homology to IFN and IFN-receptors than other cytokines/cytokine-receptors (Figures S1A and S1B; Table S3). Notably, the heterodimeric receptor subunits of the IFN and IL-10 families also sub-clustered, suggestive of a common ancestral heterodimeric receptor specific to these two families (Figure S1B). In contrast to IFNs, however, the IL-10 cytokine family has not been as clearly linked to pathogens/danger signals. This raises the tantalizing possibility that, during evolution, these pathways may have bifurcated from a common ancestor to cope with the increasing diversity of pathogens and injuries."
Thiago Carvalho
boosted
Inspired by Kate Raworth's Doughnut Economics, Anne Urai and Clare Kelly imagine an ‘academic doughnut’ for rethinking academia for climate action.
🎧 Listen in the #eLifePodcast
https://elifesciences.org/podcast/episode86?utm_source=mastodon&utm_medium=social&utm_campaign=organic
'In this Essay, we discuss recent findings related to changes in the metabolic functions of immune cells (immunometabolism), particularly mitochondrial dysfunction, in innate and adaptive immune cells and their contribution to the generation of autoimmunity, with emphasis on systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002084
Thiago Carvalho
boosted
Variation is key to the SARS-CoV-2 ‘waves’
-a new blog piece by me. If you like, please amplify by reposting.
https://virologydownunder.com/variation-is-key-to-the-sars-cov-2-waves/
Thiago Carvalho
boosted
Excess deaths align with COVID-19.
-a second blog from me, and I in one day! Please tell me re-postmboost this if you read and enjoyed.
https://virologydownunder.com/excess-deaths-align-with-covid-19/
STM is looking for an editor with experience in cardiovascular/vascular research.
'The American Association for the Advancement of Science (AAAS) and Science Translational Medicine are seeking a talented scientist, physician scientist or clinician interested in biomedical/translational research to join the Science Translational Medicine editorial team, preferably in our Washington, DC, USA or Cambridge, UK offices.'
#ScienceJobs #ScienceCommunication
'Reconvertir el viñedo en ecológico significa que todas las prácticas como el abonado, con productos fitosanitarios contra las plagas de la viña y la erradicación de malas hierbas, se ajustan a la legislación ecológica. Este plan obedece, según la enóloga de la bodega, Elisa Ludeña, a la responsabilidad que existe por parte de la propiedad en “cuanto al cuidado del suelo y de la biodiversidad y a la restricción del uso de productos químicos de síntesis”.
'In a section that suggests those closest to Johnson at the time have been obliging in spilling the beans, Seldon describes how Johnson, digesting the results at his London home, “paced around in a Brazilian football shirt and bottom-hugging shorts looking ashen-faced and distraught”. A new thought struck him: “Oh s**t, we’ve got no plan. We haven’t thought about it. I didn’t think it would happen. Holy crap, what will we do?”
https://www.ft.com/content/4288182d-db70-4bcc-9db2-fef88a0a5cf5
Thiago Carvalho
boosted
#CharlieSausageFingersGoldenHatParade #Coronation
Monty Python: "Strange women lying in ponds distributing swords is no basis for a system of government…"
The Royal Family:
Thiago Carvalho
boosted
"Berners-Lee eventually convinced CERN to release the World Wide Web into the public domain without any patents or fees. He has since attributed the runaway success of the web to that single decision."
30 years ago, one decision altered the course of our connected world
https://www.npr.org/2023/04/30/1172276538/world-wide-web-internet-anniversary
Thiago Carvalho
boosted
‘A race it might be impossible to stop’: how worried should we be about AI? https://www.theguardian.com/technology/2023/may/07/a-race-it-might-be-impossible-to-stop-how-worried-should-we-be-about-ai?CMP=share_btn_tw
'The EU is ready to agree that immediate open access to papers reporting publicly funded research should become the norm, without authors having to pay fees, and that the bloc should support non-profit scholarly publishing models.'
Molecular atlas for Crohn's disease & ulcerative colitis in patients receiving anti-TNF.
'We describe a therapeutic atlas for Crohn's disease (CD) and ulcerative colitis (UC) following anti-tumour necrosis factor (TNF) therapy. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies from 38 patients and three controls, revealing disease- and therapy-specific differences.'
#Preprint #IBD #ulcerativecolitis #crohnsdisease #immunology #TNF #immunotherapy #mucosalimmunology
Thiago Carvalho
boosted
@cyrilpedia
What an interesting paper, thank you for sharing.
The data and experiments look very solid. One comment - fig 1c is doing quite a lot of the heavy lifting in showing the specific induction of IL-24. Looks fair but how often is an injury just epidermis deep? If you get dermal injury, then IL-1b looks almost as specific a cytokine induced. Anyway, that's a separate story. IL-24 as an important local skin danger signal, I'm sold.
Thiago Carvalho
boosted
Today the government’s anti-democratic mission is seen clearly. As well as suppressing dissent through draconian anti-protest laws, the Met used live facial recognition surveillance during the coronation.
These are the tactics of authoritarian regimes.
In a democracy, protest is a fundamental right. #protest #coronation #policing #humanrights
https://time.com/6277591/anti-monarchy-protesters-arrested-king-charles-coronation/
Thiago Carvalho
boosted
Just in case anyone didn’t know, the police are currently arresting anyone peacefully protesting against the coronation and its lavish extravagance during a time of national need.
Currently. Arresting. Peaceful. Protestors.
This is not my country. This is a dystopia.
Thiago Carvalho
boosted
Thiago Carvalho
boosted
'These distinct roles for EZH2 in promoting prostate cancer progression, metastasis, and AR independence raise the possibility that it could be a potential therapeutic target in advanced disease.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002038
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
