Thiago Carvalho @cyrilpedia@qoto.org

On this day in 1813: John Snow born, pioneer in public health, epidemiology and anaesthesia #ThisDayInBiotech

On this day in 1902: Barbara McClintock born, won 1938 #NobelPrize for showing how chromosomes change #ThisDayInBiotech #WomenInBiotech

'As we headed east out of Napa city he warned me about the transformation of Contra Costa since I’d last visited in the 1980s. Back then, it was a characterful sandy wasteland dominated by pylons between patches of vines farmed by the descendants of Portuguese immigrants.'

https://www.ft.com/content/dfce4894-09a5-46f3-b360-5deeecdf3901

'Here, we generated a mouse model with insufficient ketogenesis by conditionally knocking out the gene encoding the hepatocyte-specific ketogenic enzyme hydroxymethylglutary-CoA synthase 2 (Hmgcs2 KO). Intriguingly, erythroid maturation was enhanced with boosted fatty acid synthesis in bone marrow of hepatic Hmgcs2 KO mouse under fasting condition, suggesting that systemic ketogenesis has a profound effect on erythropoiesis.'

#Preprint #metabolism

https://www.biorxiv.org/content/10.1101/2023.06.07.544102v1

Who says we don't need another heron? by @hunchbacksociety #ceramics #stoneware #art #artgallery #handmade #artmastodon

https://madalenaparreira.com/Hunchbacksociety

Back in (very sunny) Heidelberg! Looking forward to meeting students & postdocs at the Uni and reconnecting with my former colleagues at EMBO.

"These data demonstrate that IL-22 promotes DNA damage response activation in proximal tubule cells, switching pro-recovery DDR responses to a pro-cell death response and worsening acute kidney injury."
#preprint
https://www.biorxiv.org/content/10.1101/2023.06.08.544134v1

Don't wait for the earth-shattering kaboom

"This is the way the world ends. Not with a bang — that is, a sudden, universal catastrophe — but with a series of smaller, more local catastrophes that keep getting bigger and more widespread."

https://www.nytimes.com/2023/06/08/opinion/wildfires-smoke-climate-crisis.html

Scientific publication is a complex ecosystem, and there is no shortage of views on how to improve it, support it, burn it down, rebuild it, finance it, etc

But we should be able to agree on one thing: forcing authors to format manuscripts before the manuscript is accepted is an immense waste of time.

https://www.nature.com/articles/d41586-023-01846-9

Assistant or Associate Professor, Respiratory Infections in the Immunocompr

Fred Hutchinson Cancer Center

See the full job description on jobRxiv: https://jobrxiv.org/job/fred-hutchinson-cancer-center-27778-assistant-or-associate-professor-respiratory-infections-in-the-immunocompr/?feed_id=47460

#ScienceJobs #hiring #research
Seattle #Un...
https://jobrxiv.org/job/fred-hutchinson-cancer-center-27778-assistant-or-associate-professor-respiratory-infections-in-the-immunocompr/?feed_id=47460

Regulation of the length of neuronal primary cilia and its potential effects on signalling https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(23)00088-0?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Lewis Epstein's incredible book "Gedanken Physics" appears to be basically unavailable to buy in English. But the second edition is freely available on the Internet Archive! What an amazing resource. Some of the unfortunate attitudes in the book are dated but the approach to #physics through problem solving is as fresh today as it ever was.

https://archive.org/details/ThinkingPhysicsPracticalLessonsInCriticalThinking_201808/page/n24/mode/1up

Changing the reaction buttons available on social media sites could reduce the spread of fake news. https://elifesciences.org/digests/85767/combatting-online-misinformation-with-the-click-of-a-button?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Bluesky won't be a good fit for everyone, but for the science-inclined that do make their way there, be sure you land in the What's Science feed organized by @bossett.bsky.social

"‘Cybernetics and Ghosts’, the 1967 lecture that begins with the tribal storyteller, took its inspiration from avant-garde experiments with basic computers. Calvino thought that the use of machines to destabilise literary form, or produce generative disorder, was eminently human. The machine’s ‘true vocation would be for classicism’, having the capacity to infer and follow stylistic rules exactingly. It is interesting to revisit this argument in the era of AI, not least in light of Calvino’s brief, teasing claim that a true ‘literature machine’ would produce avant-garde work ‘to free its circuits when they are choked’ by classicism"

https://www.lrb.co.uk/the-paper/v45/n12/james-butler/infinite-artichoke

Madrid