Thiago Carvalho @cyrilpedia@qoto.org

'Por esta altura, os principais indicadores usados para medir a sobrecarga turística estão, em Lisboa e no Algarve, ao nível ou acima daqueles que se verificam em cidades como Barcelona ou Amesterdão, onde já há restrições pesadas à actividade turística.'

https://www.publico.pt/2024/08/15/economia/noticia/sobrecarga-turistica-lisboa-algarve-nivel-barcelona-amesterdao-2100503?ref=hp&cx=manchete_2_destaques_0

'A larger number of S. aureus macrophage pathogenesis genes (n = 27) are newly implicated by this effort, comprising 61% of genes passing experimental validation. The putative or documented roles of many mirror the functions of known virulence factors (…) However, other newly validated genes offer insight into previously unappreciated mechanisms affecting intracellular macrophage pathogenesis. The most substantial constellation of functionally related genes include fmhA [99], femA [100], femB [100], and pbp2 [100], all of which have functions in peptidoglycan assembly.'

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012394

'In addition to illuminating previously overlooked factors relevant to intracellular macrophage pathogenesis and chronic infection, these studies highlight pronounced differences between the results of in vivo and in vitro investigatory strategies. Macrophage pathogenesis phenotypes quantitatively increased during both chronic human infection and serial passaging, and most genes implicated by in vivo and in vitro strategies were confirmed to impact macrophage pathogenesis in the same functional laboratory model. Yet, despite these phenotypic similarities, only a single candidate gene was identified in common by parallel in vivo and in vitro studies.'

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012394

'Urgent efforts to roll out vaccines to tackle the Mpox international public health emergency in central and east Africa risk being hobbled by a lack of orders and logistical challenges, a leading vaccine manufacturer has said.'
https://www.ft.com/content/47e34535-2fe5-4a87-a255-2a17c1e2e8fd

'Maid’s rooms have been a fixture in Brazil’s homes for generations, a vestige of its long history of slavery and a tangible marker of inequality in a country where, after abolition, many affluent families relied on low paid, mostly Black domestic workers to clean, cook and care for children. Some worked around the clock for pennies; others toiled only in exchange for room and board.'
https://www.nytimes.com/2024/08/15/world/americas/brazil-maid-rooms-racist-past.html

'I had not been to Israel since June 2023, and during this recent visit I found a different country from the one I had known. Although I have worked abroad for many years, Israel is where I was born and raised. It is the place where my parents lived and are buried; it is where my son has established his own family and most of my oldest and best friends live. Knowing the country from the inside and having followed events even more closely than usual since 7 October, I was not entirely surprised by what I encountered on my return, but it was still profoundly disturbing.'

https://www.theguardian.com/world/article/2024/aug/13/israel-gaza-historian-omer-bartov?CMP=Share_iOSApp_Other

'However, the evolutionary comparisons of sex-biased gene expression have so far focused on comparisons between relatively distant species and relatively few individuals per species only (Naqvi et al., 2019; Rodríguez-Montes et al., 2023), making it difficult to gauge the true evolutionary rates. Here we use the house mouse radiation to address the evolution of sex-biased genes and their expression.'
https://elifesciences.org/reviewed-preprints/99602

'Ruthenium is abundant in asteroids but extremely scarce in Earth’s crust, making it a handy bellwether of past impacts by space rocks. The team searched for isotopes of ruthenium in the geological remnants of the Chicxulub impact.'

https://www.nytimes.com/2024/08/15/science/asteroid-dinosaurs-chicxulub.html

'A Direção-Geral da Saúde (DGS) esclareceu esta sexta-feira que nenhum dos casos de monkeypox (mpox) reportados em Portugal é da variante mais perigosa da doença (clade I), que apareceu na quinta-feira pela primeira vez na Suécia.'

https://expresso.pt/sociedade/saude/2024-08-16-mpox-nenhum-dos-casos-reportados-em-portugal-e-da-variante-mais-perigosa-mas-a-dgs-pede-vigilancia-e-vacinacao-3c8f2382

'We have investigated cold RNA biochemistry using single-RNA force spectroscopy. At low temperatures, we find that sequence-independent contributions of RNA–water interactions outweigh sequence-dependent base pairing, leading to misfolding of fully complementary hairpins.'

https://www.pnas.org/doi/10.1073/pnas.2408313121

Microbial reaction rate estimation using proteins and proteomes https://www.biorxiv.org/content/10.1101/2024.08.13.607198v1.full.pdf+html

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#proteomics #prot-preprint

Postdoctoral fellow/PhD candidate in non-invasive biosensing sensing (f/m/d

Technische Universität München / Chair of Biological Imaging

At CBI we are now looking for a highly qualified and passionate PhD candidate (f/m/d) to drive the development of non-invasive biosensing

See the full job description on jobRxiv...
https://jobrxiv.org/job/technische-universitat-munchen-chair-of-biological-imaging-27778-postdoctoral-fellow-phd-candidate-in-non-invasive-biosensing-sensing-f-m-d/?feed_id=80275

Kevin Gross and I have a new paper out in PLOS Biology about how the ubiquitous incentive structures that motivate hard work also discourage scientists from taking on high-risk, high-return research projects.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002750

'Segundo a organização de defesa de direitos humanos Avós da Praça de Maio, cerca de 500 bebés foram roubados pela ditadura aos pais, na sua maioria opositores ao regime, e, em muitos casos, a mães que deram à luz em centros clandestinos de detenção e tortura e que desapareceram para sempre, foram assassinadas ou atiradas com vida, mas drogadas, para o mar.'

https://expresso.pt/internacional/america-latina/2024-08-14-milei-acaba-com-a-investigacao-ao-desaparecimento-de-criancas-durante-a-ditadura-e7a1f642?utm_term=Autofeed&utm_medium=Social&utm_source=Twitter#Echobox=1723662400