DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
How amazing are my ex PhD students @JesssicaW28 @loftusro @katiezyxw and @KediaMehta, who sent me this feel better soon package.
Including a mug with lab photos across the lifetime of the Finlay lab 🥰 and a lockpicking set - that’s an important skill to have 🤣
Thank you 😊
RT @VikiLovesFACS
@Win11We If that were true, it wouldn’t be worth offering COVID vaccination in pregnancy. But in fact, COVID increases the risk of preterm birth and stillbirth. Midwives, obstetricians and parents are all keen to avoid these, so vaccination is recommended.
RT @VikiLovesFACS
@Win11We I work in a maternity unit. So it would take a supreme amount of effort to avoid talking to midwives, and indeed obstetricians, since I see them every day.
RT @MitoPsychoBio
How we think and talk about mitochondria matters to our science and to newcomers in the field.
The powerhouse analogy is expired and we need specific vocabulary to capture the beautiful complexity of mitochondrial biology.
We propose a framework and some nomenclature.
RT @HaigisLab
When do cancer cells not run a complete NADH shuttle? Check out our latest study on the glycerol-3-phoshphate shuttle in kidney cancers @MolecularCell led by Conghui Yao, an amazing postdoc! https://www.sciencedirect.com/science/article/pii/S1097276523002137?dgcid=coauthor
RT @laoneill111
Can’t beat statistics…Irish workers are the most productive in the world.
RT @kzernike
A 14-yo girl read The Exceptions and painted this picture as a tribute to Nancy Hopkins and her groundbreaking science. The artist’s mother, also a fan, presented this to Nancy last week.
Here’s to the future.
RT @CathalHarmon
Research and Innovation Bill 2023: Open Letter to Minister Simon Harris - Sign the Petition! https://chng.it/xWfBzb6g via @Change
RT @TCDPharmacy
Congratulations to all those awarded fellowship @tcddublin today and especially to two of our own- Professor Sakis Mantalaris and Professor Niamh O'Boyle! We are all so proud of you both! #celebrations #pharmacy #Trinitymonday
RT @DHSCgovuk
Vaccination is the best way to protect ourselves and our children against serious infectious diseases.
It's important that vaccines are given on time - but if you or your child have missed one, contact your GP to catch up.
#WorldImmunisationWeek #VaccinesWork
More 🔽
I’ve been thinking about using fermented foods to repopulate my gut microbiome (on lots of antibiotics lately)
Maybe not 😮🤯
‘antibiotic-resistant bacteria were isolated from approximately 90% of the retail kimchi and all artisan cheeses assessed in this pilot screening’
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RT @biorxivpreprint
Traditionally fermented foods still a critical avenue impacting host gut antibiotic resistome https://biorxiv.org/cgi/content/short/2023.…
https://twitter.com/biorxivpreprint/status/1650005836247252992
Don't you just LOVE when a paper comes out providing an explanation for a long term lab question 😀🎉 Mystery solved!!
This really nice paper just out in #PLOSpathogens
by @FirpoMason and @bryancmounce based at the Loyola University Chicago @LoyolaInDIRI. (a🧵)
Our Question?
RT @RyanLab_MBU
🚨Last weeks #immunometabolism discoveries🚨 @Bims_BiomedNews ⬇️⬇️⬇️
http://biomed.news/bims-imicid/2023-04-23
Highlights:
I) MYC-SLC7A5-glycolysis metabolic axis regulates MAIT cell proliferation & is impaired in obesity
II) Hypusination regulates SREBP2 translation & enterovirus infection
RT @UMassMetNet
Had a wonderful day with guest "Fluxing Star" Evanna Mills (sporting a MetNet T-shirt!) who's seminar on how metabolites function as signaling molecules was outstanding! Learn about Evanna and her amazing ability to hold a plank at the Metabolog - https://www.umassmed.edu/metnet/blog/2023/04/evanna-mills/
RT @FrezzaLab
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis https://www.science.org/doi/10.1126/scisignal.abo2709#.ZEA7hSv8iyY.twitter
RT @AislingRehill
Delighted to share a pre print of my work looking at the intersection of inflammation, glycolysis and thrombosis. Thanks to all our collaborators for contributing to this exciting story! @rogerjspreston
@PrestonLab_RCSI @RCSIPharmBioMol @IrishCtrVascBio https://www.biorxiv.org/content/10.1101/2023.04.20.537683v1
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
>100 RNA binding proteins identified that bind to 3’UTR of cytokine mRNA (IFNg, TNF and IL2) in Human T cells.
#immunometabolism finding (Supl Tables 1 and 3)
GAPDH binding to cytokine 3’UTR in PMA/Ionomycin activated, but not untreated, Human T cells.
DaveFinlayTCD
boosted
Very pleased to see our paper is now in print:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00430-8
here we show how RNA binding proteins regulate the magnitude and timing of cytokine expression in human T cells. and how the identified RBPs act a different time points and through different mechansism. The wonder world of RNA...
#RNA #RBPs #Immunology #Tcells #cytokines #regulation #proteomics
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
