DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
How to stop Killers from turning on each other?
Engineering CAR-NK cells with ‘don’t kill me’ ligands circumvents problem of trogocytosis-mediated fratricide.
RT @DanielJDrucker
Careful how you mess with Acetyl-CoA carboxylase. A critical role for ACC in metabolic regulation of the innate immune response in macrophages @ScienceAdvances https://www.science.org/doi/10.1126/sciadv.abq1984
DaveFinlayTCD
boosted
Wondering how accurate #AlphaFold models are?
We compared #AlphaFold predictions with experimental data. Many parts are great, but even high-confidence #AlphaFold predictions have distortions, domain movements, backbone errors, and side chain errors.
Some great advise for young scientists from Ben Feringa:
👉withstand failure
👉show perseverance
👉take inspiration from small successes.
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RT @NobelPrize
"If you want to be a scientist, you have to withstand failure."
Listen to chemistry laureate Ben Feringa give advice to young science students on how to tackle failures.
Watch the full student session with Feringa here: https://www.youtube.com/watch?v=vpPfb6CscyI&t=1438s
https://twitter.com/NobelPrize/status/1595117014733193216
RT @roserventotormo
Delighted to receive #ERCStG to continue studying early cell fate decisions in the placenta using high-throughput genomics, computational/AI and synthetic biology tools!
Now, that is some good multi-tasking !!!
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth
Great article providing interesting insight into how #mastodon is different to the #birdsite. Seems to me like a much more wholesome place to be. https://www.wired.com/story/the-man-behind-mastodon-eugen-rochko-built-it-for-this-moment/
DaveFinlayTCD
boosted
Last week I heard a speech by Prof. Dame Sarah Gilbert. She of the Oxford vaccine. A woman whose team's work is calculated to have saved several million lives. She warned that Britain's dismal failure to remember, learn and expand on the hard fought achievements of the last few years placed us back to square one when (not if) it happened again.
This piece is a depressing demonstration of that.
A new (but also ancient) mTORC1 inhibitor——“mTORC1 senses the capacity of a cell to synthesize FAs by detecting the levels of malonyl-CoA”
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RT @DemetriadesLab
⚡️New @biorxivpreprint from the lab!⚡️
Wonderful collaboration with the labs of @CDV1893, @TelemanLab, and @LabVanni, spearheaded by @Raf_Nic and @laura_brohee.
Short 🧵 below 👇
https://www.biorxiv.org/content/10.1101/2022.11.06.515351v1
https://twitter.com/DemetriadesLab/status/1592982245005852672
Should have been “in VIVO or directly ex vivo” - unfortunate typo 🫣🤣
To those feeling an energy barrier about #MastodonMigration, it is easy. Once set up, you can cross-post between #Twitter and #Mastodon using: https://moa.party. They are essentially mirrored, post on one = post on both. One fails (#Twittershutdown) you have one left 👍
Really nice paper and great reminder that in vitro metabolism is not the same as in vivo metabolism. #Immunometabolism needs to move in vivo. Try #QUAS_R to look at in vitro or direct ex vivo glutamine uptake https://www.biorxiv.org/ 😉
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RT @LyssiotisLab
Hyping new @SciImmunology from @_Hanna_Hong (before #Twitter burns down 🔥)
➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumo…
https://twitter.com/LyssiotisLab/status/1593680601730625536
RT @LyssiotisLab
Hyping new @SciImmunology from @_Hanna_Hong (before #Twitter burns down 🔥)
➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment ⬅️
Read on for a #tweetorial
http://www.science.org/doi/10.1126/sciimmunol.abm8182
DaveFinlayTCD
boosted
To all immunologists who don‘t yet know: Check out this great seriers of online talks (also available on demand) - Global ImmunoTalks: https://labs.biology.ucsd.edu/zuniga/global_immunotalks.htm
DaveFinlayTCD
boosted
#Introduction time. I’m a postdoctoral research associate at the University of Glasgow Research interests include #adipocytes #adiposetissue #metabolism #immunometabolism #immunity and #IL-17 ! I also founded The STEM Village, an initiative to promote visibility of #LGBTQ people in #STEM 🏳️🌈🏳️⚧️🏳️🌈🏳️⚧️🏳️🌈🏳️⚧️ you can find out more on our website https://www.thestemvillage.com or our #YouTube channel https://youtube.com/channel/UCULuHvpzPgU2SDd0unWAMCw
One focus of our lab is to understand how altered nutrient levels in the Tumour micro environment #TME affect #NKcell cytotoxicity. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02377-8
We recently developed a new single cell assay (QUAS-R) to measure glutamine uptake through Slc1a5.
Check it out on BioRxiv https://www.biorxiv.org/content/10.1101/2022.09.29.510040v1. Fun collaboration with Linda Sinclair and Sander van Kasteren
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
