DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
RT @CerwenkaLab
For the end of 2022: interesting observations by Ming and Ana - microenvironment matters! @jmingeum @MolBiol_Immunol https://twitter.com/MolBiol_Immunol/status/1605164329308921856
RT @FrezzaLab
I am incredibly happy to share this work from our lab and @saezlab, and a lot of fantastic collaborators. We hope you enjoy it!
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression | Nature Communications https://www.nature.com/articles/s41467-022-35036-4
Neutrophils are a real metabolic enigma!! They are packed full of glycogen particles and now it appears that beta oxidation is crucial in getting them to the site of infection. Maybe they save the glycogen as fuel for when they arrive? 🤷♂️🧐🤓
What a great approach; Nano sheets that do the same job as Lactate Dehydrogenase, consume lactate making pyruvate. I can think of a few more enzymatic activities that I would like in a nanoparticle format. Beyond my skill set though 🤷♂️
Engineering amino acid metabolism in CAR-T cells #Slc7a5 #Slc7a11
Very interesting approach. We are now regularly seeing metabolic engineering strategies to improve cellular immunotherapies.
#immunometabolism
Interesting new piece to the Srebp puzzle. Glutaminolysis released ammonia activated Srebp by disrupting scap-insig interaction. This effect of ammonia is blocked by 25-Hydroxycholesterol.
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RT @NatMetabolism
🏆 Best of #NatMetab2022 | CITATIONS
#11
The team led by Deliang Guo (@OhioState) shows that ammonia released from glutaminolysis disrupts the SCAP/Insig association, thus activating SREBP-1 and promoting lipogenesis to suppor…
https://twitter.com/NatMetabolism/status/1604209063729893376
Congratulations Lorraine, very well deserved 😁
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RT @DonnachaOD
Very proud of my brilliant wife Lorraine who was formally inducted into the RIA along with some other luminaries including her good friend and colleague @ProfJohnCrown. #ria
https://twitter.com/DonnachaOD/status/1603803374427815941
Very interesting read. Though my wife did call me a super nerd when she realised what I was reading on my lazy Saturday morning in bed 🤷♂️🤣. Call a spade a spade 🤣
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RT @Plasmacellguy
(1) When I wrote the last tweet, there was one troubling question lurking and looming and causing pain.
These memory T cells are dividing A LOT, way beyond the Hayflick limit (60 divisions)....How?
Let me start with a summary of what we know about…
https://twitter.com/Plasmacellguy/status/1603745921468170242
RT @drmgmonaghan
Huge congrats to @NGBNeto on a FLIMpressive PhD Viva! 3 first and TEN coauthor papers, and a long lasting mark on microscopy in Dublin. Sincere appreciation for the great discussions with examiners @DavidFinlayTCD and @melissa_skala and @TrionaLally as chair.
#proudsupervisor
RT @VikiLovesFACS
A real pleasure to visit @ClionaOfarrelly’s lab to examine @FGiangrazi’s thesis.
From now on, I will insist that all PhD vivas end with the examiner sitting on Oscar Wilde!
RT @lum_lab
What transporter is responsible for uptake of our recently discovered immunosuppressive metabolite (MNA)? And can we target it? Jessica, one of our newest graduate students is working on it! -SM1
RT @PaoloCrosetto
Yesterday I circulated a plot I made about ERC grantees.
I made a horrible mistake: I mistook Ireland (IE) for Israel (IL). The data concern Israel and **not Ireland**.
Also, data covers 12 largest ERC host countries.
I apologize. Here is the correct plot.
RT @KEnglishLab
Super story on base editing of CAR-T to treat difficult blood cancer. Ill be covering this next semester in my BI206 Cellular Biotechnology module @MaynoothBiology @MaynoothUni https://www.bbc.com/news/health-63859184
RT @FrezzaLab
Elevated methionine flux drives pyroptosis evasion in persister cancer cells https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-22-1002/711509/Elevated-methionine-flux-drives-pyroptosis-evasion/
RT @PaoloCrosetto
Does your (EU) country attract or lose top researchers?
AT, CH attract a lot.
FR, DE, BE, ES are open places: as many leave as arrive.
IE is a closed system.
Italy, there is something very wrong: *very* few come, many go.
Plot made with @ERC_Research data.
RT @McLoughlin_Lab
If you are interested in understanding more about how the immune system is modulated by it’s interaction with that fascinating bacterium Staphylococcus aureus come and join us in Dublin @tcdTBSI https://www.jobs.ac.uk/job/CSY565/post-doctoral-research-fellow-investigating-host-microbe-interactions
Great opportunity here! Snap it up .
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RT @McLoughlin_Lab
Post Doc position available in my lab @tcdTBSI twitter please spread the word https://www.jobs.ac.uk/job/CSY565/post-doctoral-research-fellow-investigating-host-microbe-interactions
https://twitter.com/McLoughlin_Lab/status/1570488466965942272
RT @dundeeuni
The acidity of tumours impairs the effectiveness of anti-cancer therapies, according to a study led by Dr Ignacio Moraga, @UoDLifeSciences. The findings could lead to a new generation of immunotherapy treatments.
More 👉 https://buff.ly/3VPspcy
RT @SNI_NKMeeting
Putting together a great program for NK2023, registration opens January 15! More info to come at http://nk2023.org
RT @RCSI_Irl
RCSI research published today in @NatureComms could help improve the effectiveness of #vaccines.
The study shows how our circadian clock is changing the shape of mitochondria within a key immune cell, influencing our vaccine response.
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
