Mayra Carneiro @mayra@qoto.org

Women weren't allowed to major in genetics when Barbara McClintock attended Cornell, so she earned her PhD in botany instead.

Working on the chromosomal activity of maize in the '40s and '50s, she discovered genetic transposition, proving that genes turn physical characteristics on and off.

Initially met with skepticism, her work was confirmed in the '60s and '70s; she won the Nobel Prize in Physiology or Medicine in 1983.

#WomensHistoryMonth

https://www.energy.gov/articles/five-fast-facts-about-barbara-mcclintock

graphic: Cort Kreer

Referenced link: https://www.nature.com/articles/s41591-023-02234-6
Discuss on https://discu.eu/q/https://www.nature.com/articles/s41591-023-02234-6

Originally posted by Nature Portfolio / @NaturePortfolio: http://nitter.platypush.tech/NaturePortfolio/status/1637194685767733248#m

A study in @NatureMedicine identifies conserved microbiome features across clinical and geographical variations, which may enable cross-cohort microbiome-based predictions of outcomes in CAR-T cell immunotherapy. 🔒 https://www.nature.com/articles/s41591-023-02234-6

A milestone for a young field:

Our community recommendations for single-cell proteomics are published OA:

https://www.nature.com/articles/s41592-023-01785-3

'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'

#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity

https://onlinelibrary.wiley.com/doi/10.1002/art.42482

#POSTDOC JOB ALERT #Switzerland #bioinformatics

Love coding, #singlecell, statistics, immunology, mountains?

Want to work in a motivating, cutting-edge #translational #cancer research environment?

#Great #article on the #molecule I #LOVE the #most -#TCR @ImmunityCP @NillaKH
---
RT @NillaKH
Our new paper by Corcoran et al., just out in @ImmunityCP, reveals a high variation in human T cell receptor germline genes. The alleles vary greatly in frequency between population groups and some are, surprisingly, inherited from our archaic relatives. https://authors.elsevier.com/sd/article/S1074-7613(23)00038-9
https://twitter.com/NillaKH/status/1625906243175952408

The latest episode of the #EMBOPodcast is live & (in my biased opinion) this should make for some great weekend listening.
@CoriBargmann & I discussed the evolution of behavior, #OpenScience, a worm’s sense of smell, the Human #Brain Initiative, mentorship, and much more.

You can listen to it at the link below or your preferred podcast app

#neuroscience #Celegans #oncogenes #sciencepolicy #mentorship #SciComm #SciencePodcast

https://www.embo.org/podcasts/our-special-feature-as-humans-is-communication/

"Almost two-thirds of sharks and rays that live around the world’s coral reefs are threatened with extinction with potentially dire knock-on effects for ecosystems and coastal communities, according to new research."

#Conservation

https://www.theguardian.com/environment/2023/jan/18/extinction-crisis-of-sharks-and-rays-to-have-devastating-effect-on-other-species-study-finds

Excited to share our comprehensive new review on T follicular helper cells in cancer in Trends in Cancer! This work was spearheaded by talented Nicolás Gutiérrez-Melo with a focus on the role of Tfh cells in solid tumors & irAEs. https://doi.org/10.1016/j.trecan.2022.12.007

Here are some highlights from the freely accessible article... 🧵

''Here, we introduce the #Preprint Club, a cross-institutional, community-based approach to peer reviewing, founded by ECRs from the University of Oxford, Karolinska Institutet and Icahn School of Medicine at Mount Sinai. Over the past two years and using the collaborative setting of the Preprint Club, we have been discussing, assessing, and providing feedback on recent preprints in the field of #immunology.''

https://www.biorxiv.org/content/10.1101/2023.01.04.522570v1

Draw cells in RShiny! https://github.com/svalvaro/drawCell

A very cool find thanks to the Appsilon blog.

My latest clinical pipeline column for Nature Medicine is a look at a drug recently approved by the #FDA to delay the onset of type 1 diabetes.

It's a direct descendant of the very first monoclonal ever approved for clinical use.

#Diabetes #Type1Diabetes #DrugDevelopment #DrugDiscovery #NatureMedicine #Immunology #MonoclonalAntibody

https://www.nature.com/articles/d41591-022-00115-y

OK, this is an experiment posting longer pieces to #ScienceMastodon, so consider this 1/n.

I wanted to share a fascinating piece of #ScienceHistory that I stumbled across not long ago while rummaging through old papers from early #genetics labs at the University of Texas. Deep in boxes of classic reprints, I found correspondence between Barbara McClintock, the famed Cold Spring Harbor labs maize geneticist, and UT fly geneticist Wilson Stone.

from @nslavov

How predicative are transcriptomes of cell fate choices?

This @ScienceMagazine article suggests that transcriptomes have limited predictive power for developmental fates during hematopoiesis.

The highest predictive accuracy from RNA levels was 60% in vitro and 51% in vivo.

https://twitter.com/slavov_n/status/1602370160291188763?s=12&t=TxyaDF81IYtQhPhcQ5MMJQ

https://towardsdatascience.com/deseq2-and-edger-should-no-longer-be-the-default-choice-for-large-sample-differential-gene-8fdf008deae9 when sample size >8, use Wilcox rank sum test to find DEG #rnaseq

Hello, world!