Dan Mucida @mucida@qoto.org

Gut tregs:

"Thus, Helios+ effector tTregs proliferate via CD28 and require neither ICOS nor MHCII for maintenance. In contrast, RORγt+ pTregs utilize CD28 and ICOS."

cc @mucida

https://www.mucosalimmunology.org/article/S1933-0219(23)00017-X/fulltext

Changes in the number of copies of the genes involved in protein production affect how bacteria grow in response to abundance and famine. https://elifesciences.org/digests/81005/growing-fast-and-slow?utm_source=mastodon&utm_medium=social&utm_campaign=organic

"Scientists, clinicians and medical technologists in LMICs need to be empowered to design, maintain and build low-cost MRI systems on site6. And to do so, they need access to open-source hardware and software, in line with the United Nations’ 2020 Roadmap for Digital Cooperation, which stresses the need for digital inclusion for all, and for building architectures for digital cooperation."

https://www.nature.com/articles/d41586-023-00759-x

My latest Clinical Pipeline column for #NatureMedicine is now online. A new take on heart failure using iPSC derived cardiomyocytes.

#drugdevelopment #cardiology #stemcells #regeneration

https://www.nature.com/articles/d41591-023-00027-5

Worse than useless:

"In the decades since, the military returned to the barracks, but its withdrawal was always conditional. The tenure of Jair Bolsonaro, a former army captain, brought the military back to the heart of government. He might have grudgingly left office, but Brazil’s military — privileged, preponderant and unaccountable — remains a constant threat to the country’s democracy."
cc @mucida
https://www.nytimes.com/2023/03/06/opinion/brazil-military-bolsonaro.html?smid=nytcore-ios-share&referringSource=articleShare

I can't believe I missed this podcast last year: Ta-Nehisi Coates on Tony Judt
cc @mucida
🎧 👇

https://www.publicbooks.org/primary-sources-ta-nehisi-coates-on-tony-judt/

"These are not ordinary conservatives. They are extremist politicians who seem to celebrate the period of brutal military dictatorship, when, beginning in 1964, the military dissolved Congress, suspended constitutional rights, and imposed extensive censorship; democracy was not restored until 1985. They claim that the great mistake of the military regime was “to torture but not kill,” as Bolsonaro himself declared in 2016."
cc @mucida

https://www.nybooks.com/articles/2023/02/23/brazil-at-the-crossroads-vanessa-barbara/

Understanding the impact of #climatechange and also #oceanacidifcation on
#marine #ecosystems requires study across multiple trophic levels.

This valuable new review explores the importance of #zooplankton and their response to #climatechange highlighting the likelihood of increases in CO2 from zooplankton respiration but a number of knowledge gaps to address.

Find out more in Nature Communications on:

https://www.nature.com/articles/s41467-023-36241-5

#ecology #ClimateCrisis

'The Stasi and the censors never felt that they had really understood Neumann’s novels or deciphered what he was saying in them. Their training assured them that all creative writing conveyed a sociopolitical message, and they suspected that Neumann’s message—hidden in cryptic prose crammed with strange allusions and enigmatic comments—was a hostile one. But they never decoded it. This was because there wasn’t any message. Neumann’s fiction was certainly opaque, but the truth was that the literary sentinels of the GDR were stupid—sometimes comically so.'

https://www.nybooks.com/articles/2023/02/09/sonnets-for-the-state-stasi-poetry-circle-oltermann/