#nucleoside

How do mitochondria obtain the #ribonucleotides they need for organellar transcription?
Thomas MacVicar, Thomas Langer and colleagues show key fueling role of #mitochondrial #nucleoside diphosphate kinase #NME6 that phosphorylates #pyrimidine nucleosides
https://www.embopress.org/doi/full/10.15252/embj.2022113256

#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200

Development of a #nucleoside-modified #mRNA #vaccine against clade 2.3.4.4b #H5 highly pathogenic #avian #influenza virus, https://doi.org/10.1101/2023.04.30.538854

Carbasugar #nucleoside analogues often lack biological activity, which is attributed to an unfavorable conformation. Locked nucleoside analogues, however, can mantain the ribose-like conformation. Another synthetic access is published in #OrgLett by Lak Shin Joeng and colleagues from Seoul National University (S. #Korea)

They were able to report the synthesis of the conformationally locked cytidine nucleoside analogue in 19 steps.

#chemistry #MedChem @chemistry
https://pubs.acs.org/doi/10.1021/acs.orglett.2c03853

It is expected to be a promising agent in the treatment of various ailments and diseases.

Adenosine can be metabolized both externally and internally. Externally, an enzyme called adenosine deaminase is responsible for transforming adenosine into inosine. Additionally, a protein called equilibrative #nucleoside #transporters (ENTs) helps to bring the #extracellular activity of adenosine to an end.

A multivalent #nucleoside-modified #mRNA #vaccine against all known #influenza virus subtypes, https://www.science.org/doi/abs/10.1126/science.abm0271