"Using a murine myeloma model, Minnie et al. characterized a terminally exhausted CD8 T cell subset in the bone marrow tumor microenvironment that expressed not only transcription and epigenetic factors associated with exhaustion but also effector molecules, including IFN-γ, granzymes, and perforin."

science.org/doi/10.1126/sciimm

I cried at the Voyager news today. I also know why.

Because for every techbro out there, there's a talented engineer quietly working to make things actually better.

That gives me hope.

Hope is in short supply these days.

'O biólogo assume que, ainda antes da candidatura, quando se descrevia como "candidato a candidato", tinha a ambição e a esperança de ocupar o primeiro lugar da lista do Livre ao Parlamento Europeu. Se for eleito, quer "humanizar a entrada de pessoas na Europa" e "priorizar a conservação e até o restauro dos ecossistemas". Com 28 anos, fala na "responsabilidade" de representar uma geração poucas vezes ouvida.'

publico.pt/2024/04/22/politica

'Ms. Meloni has been at the forefront of plans to further outsource the bloc’s border policing to autocratic North African countries. In July last year, she was in Tunisia to announce a deal to curb migration across the Mediterranean; last month, she did the same in Egypt. Both times she was flanked by Europe’s top official and president of the commission, Ursula von der Leyen, who in January gave her blessing to Ms. Meloni’s broader vision for E.U.-Africa relations.'

nytimes.com/2024/04/22/opinion

@FantasticalEconomics @spaceghoti

My homeless nephew was jailed over 200 times. It did nothing to make him less homeless.

'Low- and middle-income countries already account for about 70 per cent of cancer deaths worldwide, but often lack the diagnostic capabilities that are available in richer nations, the paper says. Fewer than 30 per cent of low-income countries have such facilities generally available, meaning that the rate of undetected disease is high, according to the World Health Organization.'

ft.com/content/6bef73f5-ed50-4

This linocut proved popular when I was at Liverpool Print Fair over the weekend, so I thought I'd share it here. 15 x 10 cm, it's hand-pressed to a lightweight Japanese paper (Awagami Kozo Natural Select). It went under the working title 'Stubble', but in the end I editioned it as one of a pair and under the title 'Boundary II'.

#art #linocut #prints

'This award will fund teams of technology developers and users to create novel bioimaging tools at the cell-tissue scale. Successful teams will develop technologies that answer ambitious research questions or that overcome barriers to bioimaging work in low-resource settings.'

wellcome.org/grant-funding/sch

Postdoctoral researcher in the Tiriac lab - Developmental Neuroscience

Vanderbilt University

Tiriac lab is seeking a postdoc to join our team! Apply if you are interested in studying sensory processing or the development of the nervous system.

See the full job description on jobRxiv: jobrxiv.org/job/vanderbilt-uni...
jobrxiv.org/job/vanderbilt-uni

'We show that species occurring in highly seasonal environments display strong plasticity, while species in less seasonal or aseasonal environments exhibit surprisingly variable degrees of plasticity, including strong to no plasticity.'

academic.oup.com/evolut/advanc

'The case sent a shiver of fear through the sovereign debt world, given how it could potentially wreck any country’s attempts to extricate itself from a debt crisis. If a creditor could refuse a restructuring offer and hold it hostage until it was repaid in full, why would anyone ever agree to one?'

ft.com/content/b9a5f679-3f6d-4

'For most of its 100 years Novo Nordisk has been focused on the steady business of treating diabetes, one of the world’s most prevalent chronic diseases. Even today, it produces half the world’s insulin. But the development of Ozempic and Wegovy has led to a bigger and bolder ambition to “defeat serious chronic diseases.” That includes treating, and even preventing, obesity, which is linked to other health issues like heart and kidney diseases.'

nytimes.com/2024/04/20/busines

4 years ago today, Dr. Fauci contradicted Trump's claim that Covid would magically go away before the fall. After that, Fauci was sidelined from public briefings & barred from speaking to press.

During the greatest national crisis of our time, all Trump cared about was his ego

'Much as ChatGPT learns to generate language by analyzing Wikipedia articles, books and chat logs, Profluent’s technology creates new gene editors after analyzing enormous amounts of biological data, including microscopic mechanisms that scientists already use to edit human DNA.'

nytimes.com/2024/04/22/technol

"Literature was born not the day when a boy crying wolf, wolf came running out of the Neanderthal valley with a big gray wolf at his heels: literature was born on the day when a boy came crying wolf, wolf and there was no wolf behind him. That the poor little fellow because he lied too often was finally eaten up by a real beast is quite incidental. But here is what is important. Between the wolf in the tall grass and the wolf in the tall story there is a shimmering go-between. That go-between, that prism, is the art of literature."

themarginalian.org/2014/02/21/

Study of 3,495 social categories (like 'nurse' or 'banker') finds gender bias is more prevalent in images than in text. The underrepresentation of women online is substantially worse in images than in text, public opinion, or US census data.
nature.com/articles/s41586-024

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