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Hao Yin

Piezo1 promotes high Phosphate-induced & osteogenic differentiation of cultured👤aortic SMC (& culture🐭aorta)

How Piezo1-Ca2+ elevates expression of Runx2 & Transglutaminase 2?

Dr. Beatrix Dienes lab Front Physiol 2022
frontiersin.org/articles/10.33

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Hao Yin

3D hydrogel model (EC+SMC+Astrocyte, ɸ 600 µm)
+Defined, zonated flow profiles

Transcriptomics of with Disturbed vs Laminar flow for 24 h->
in

Dr. Peter Galie lab Fluids Barriers CNS 2022
fluidsbarrierscns.biomedcentra

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Hao Yin boosted
Development

Issue 22 is complete!

On the cover: A Drosophila egg chamber showing endogenous expression of Midline (green), which sets the posterior boundary of the dorsal appendage primordia, marked by Broad (red). See Stevens et al.
journals.biologists.com/dev/ar

Also in Issue 22:
- Research Highlights on polarity, germ cells, gastruloids & roots
- Two In preprints articles
- Spotlight on age reprogramming
- A hypothesis on TEs & regeneration
- Cranium development Review

journals.biologists.com/dev/is

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Hao Yin

internalizes-cleaves-degrades α-Synuclein aggregates, even in co-culture with "professional" Microglia😎 (relative efficiency?🧐)

How α-Syn fibril uptake impact pericyte metabolism & functions?

Dr. Birger Victor Dieriks & Mike Dragunow labs @PLOSONE 2022
journals.plos.org/plosone/arti

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Hao Yin boosted
Joachim Goedhart

Bright and sensitive red voltage indicators Cepheid1b/s based on #mScarlet and #mRuby for imaging action potentials in brain slices and pancreatic islets

biorxiv.org/content/10.1101/20

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Hao Yin

@MarkELindsay

$150! :awesome:
Is there a waiver one can apply for :ablobaww:

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Hao Yin

jointly degrade fibrillar α-Synuclein cargo by distribution through

-mediated social behaviors of Microglia

Microglia take α-Synuclein from & send Mitochondria to overloaded neighbors

Dr, Michael Heneka lab @cellcellpress@twtr.plus2021
cell.com/cell/fulltext/S0092-8

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Hao Yin boosted
Mark Lindsay

For clinicians or scientists interested in the clinical management of aortic diseases, join us tomorrow for a live virtual CME course: advances.massgeneral.org/cardi

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Hao Yin boosted
Development

In preprints: humans, the new model organism

James Wells and Ziyuan Guo highlight three preprints that use hPSC-derived tissue to dissect human development and disease.

journals.biologists.com/dev/ar

Get in touch if you would like to write an ‘In preprints’ article for @Dev_journal. We’re particularly keen to see collaborations between junior and senior PIs, and between researchers who haven’t previously worked together.

#preprints #devbio #devbiol

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Hao Yin

My continued biomedical education

Multimodality imaging of large-vessel

Aorta/Coronary artery/Pulmonary artery

Echo
CT
MRI
18F-FDG PET

Dr. Jason Tarkin & Deepa Gopalan @Heart_BMJ 2022 @Jmtarkin
heart.bmj.com/content/early/20

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Hao Yin

An impressive panorama of Trimethylamine N-oxide/TMAO on👤aortic
⏫Traits of /Inflammation
Metabolic reprogramming
Kinome & transcriptional network

Intriguing role of PERK & mitoROS

In addition to Liver, Aorta (/#Pericyte/Fibroblast/Mɸ?) may🤔 also oxidize -derived trimethylamine/TMA into Trimethylamine N-oxide/TMAO

What is the local/Aortic vs circulating TMAO level?🧐

Wait for🐭tissue-specific KO of FMO3 (Oxidizing TMA)😆

Dr. Xiaofeng Yang lab JCI insight 2022
insight.jci.org/articles/view/

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Hao Yin

MRTF-A as a deacetylation target of Sirt6 in

Deactylated MRTF-A stays in cytoplasm, failing to mediate oxLDL-induced EC ICAM1

An OxLDL-DNMT1 cacade epigenetically silences Sirt6 expression

Dr. Qianyun Wang, Tianfa Li & Qianwen Zhao labs Cell Death Discov 2022
nature.com/articles/s41420-022

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Hao Yin boosted
Joachim Goedhart

New #preprint from our lab 🎉 :toot:
We report an iLID-nanobody fusion to enable #optogenetic recruitment to #GFP. This is potentially interesting when you already have a cell line or model organism expressing a GFP fusion protein.
biorxiv.org/content/10.1101/20

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Hao Yin boosted
Costa lab

RT @fabian_theis@twitter.com

1/n Single-cell data analysis is complex with many tools to choose from - but which ones work best and should be used when? Led by @lukasheumos@twitter.com and @AnnaCSchaar@twitter.com, we wrote a free online book that aims to guide single-cell data analysts: sc-best-practices.org

🐦🔗: twitter.com/fabian_theis/statu

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Hao Yin

N308K/A313S, a variant
⏬deacetylase/deacylase
⏫mono-ADP-ribosylase
⏬LINE1 retrotransposition
⏫DNA repair
⏫tumor killing

Lamin A is mADP-ribosylated by Sirt6!

Love to explore its benefit over blood vessels!

Dr. Andrei Seluanov, Yousin Suh, Vera Gorbunova labs EMBO J 2022
embopress.org/doi/full/10.1525

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Hao Yin

Multi-agent-based computational modeling of from a single proliferating cell

High Matrix density & dynamic viscosity->
Formation of multiluminal structure instead of a single cyst lumen

This is a very easy-to-read computational modeling paper (minimal math requirement😁)
Cell cycle/polarity/secretion
Cell-cell (attractive+repulsive) + cell-fluid interaction (repulsive) + cell-matrix interactions
Geometry & Biomechanics (but not biochemical property of matrix)

Dr. José Manuel García-Aznar lab Eng Comput 2022
link.springer.com/article/10.1

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Hao Yin boosted
bioRxiv

CiliaMiner: an integrated database for Ciliopathy Genes and Ciliopathies biorxiv.org/content/10.1101/20

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Hao Yin boosted
Joachim Goedhart

Reading and converting #FLIM data from our new #Leica Stellaris8 microscope. This is a 'lifetime stack' showing different fluorescence decay rates for nucleus (fast) and cytoplasm (slow).
#FALCON

1
Hao Yin

K63 of by SKP2 ⏫its nuclear import🤠

Synergized with mTORC1-PERK-ATF4 axis in renal 🐭

A -specific regulation of YAP?😆

Dr. Andrew Karaplis lab JCI 2022
jci.org/articles/view/153943

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Hao Yin

(4 vs 11 kPa) of GelMA Substrate regulates👤Lung Fibroblast

Proliferation
Cytoskeleton
Matrix deposition (Decorin/Collagen/Microfibril)
Secretome (IL6)

Fig 4↔️6?🧐

Dr. Janette Burgess lab Front Pharmacol 2022
frontiersin.org/articles/10.33

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