Hao Yin @HaoYin@qoto.org
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
Cell Encapsulator made as PLLA/PLGA (50:50) electrospun porous (750 nm) scaffold
⏫👤Cardiac mesenchymal cell survival (1 mo in vivo) & #Exosome secretion
Implanted locally->⏫🐭#Limbischemia & #MyocardialInfarction
Dr. David Lundy lab J Controlled Release 2022
https://www.sciencedirect.com/science/article/pii/S0168365922007350
Hao Yin
boosted
In preprints: improving and interrogating embryo models
Antonio Scialdone and Nicolas Rivron discuss the fast developing field of embryo models, highlighting two preprints with new methods for ensuring reproducibility and investigating complexity.
SM22+ #SmoothMuscleCell LRP1 KO->
Spontaneous #SuperiorMesentericArtery Aneurysm
Baseline+Injured carotid arterial defect
(Intensive neointimal Elastin deposits!😈)
⏫Angiotensin+TGFβ signals
Dr. Alan Daugherty & Dudley Strickland labs @JCI_insight 2022
https://insight.jci.org/articles/view/164751
There is a long research history on LRP1 with SMC & arterial wall integrity, starting with this👇
LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis
Dr. Joachim Herz lab Science 2003
https://www.science.org/doi/10.1126/science.1082095
TMEM100, a selective human mouse Lung #EndothelialCell Marker
Higher in Capillary EC & Aerocyte than in arterial/venous EC
TMEM100⏫EC proliferation
Detected in scattered Tmem100+ Lymphatic EC & pericyte
Look forward to Tmem100-CreERT2🐭for Lung diseases😁
#PAH #PulmonaryFibrosis #Emphysema #coronavirus
Dr. Zhiyu Dai lab @atvbahajournals 2022 @joeydai
https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.122.317683
Mine your own endothelial gene of interest here
https://www.ebi.ac.uk/gxa/sc/experiments/E-MTAB-8077/results/tsne
Hao Yin
boosted
RT @CampasLab
Very excited to share the latest work from our lab, led by great postdoc @AntoineVian. We developed a new technique to measure osmotic pressure directly in vivo and in situ, within living tissues. Check out the 🧵 below or the preprint in the link here ➡️https://www.biorxiv.org/content/10.1101/2022.12.04.519060v1
Thx, will try😆
Hao Yin
boosted
RT @GrubbLab@twitter.com
When axons regrow after injury, how do they get their presynaptic terminals working again?
Answer is: really quickly!
Out now from us in @CellReports@twitter.com, led by the structure-function DreamTeam that is @LorcanBrowne@twitter.com & @ACrespoVieira@twitter.com ⤵️
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01633-3
(1/6)
Rictor is an FGF2-responsive gene in #EndothelialCell
Embryonic EC Rictor KO dampens FGF-dependent #Angiogenesis in multi-organs (& delays ossification of digit bones+vertebrae😎), leading to embryonic lethality
Dr. Rok Humar lab @SciReports 2015
https://www.nature.com/articles/srep17705
Rictor, a core mTORC2 component, as an #EndothelialCell Mechanotransducer
EC Rictor KO in young🐭->
⏬Shear (2 or 15 dyn/cm2)-induced HUVEC alignment
⏬VE-cad junction
⏬Low shear-induced vWF
Dr Shao-Liang Chen & Jun-Xia Zhang labs @FrontCellDevBio 2022
https://www.frontiersin.org/articles/10.3389/fcell.2022.963866/full
Hao Yin
boosted
We're looking for a new Community Manager for the Node! @helenzsci is leaving the Node 🙁 to take on the role of Community Manager at our sister site @focalplane_jcs 😀 so there's an opportunity for someone new to join the Node and @Dev_journal team!
If you're a developmental/stem cell biologist keen on #scicomm and community building, this could be the role for you! Full details: https://www.biologists.com/wp-content/uploads/NodeComMan.pdf.
Application deadline 15 January 2023.
Do get in touch if you want to find out more.
Hao Yin
boosted
MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities
Congrats to Flavio Maina, Celia Sequerra, Margherita Grattarola and colleagues
Hao Yin
boosted
RT @YuanhuaHuang@twitter.com
A great opportunity for summer research & fun! https://twitter.com/hkuniversity/status/1599585586444394497
🐦🔗: https://twitter.com/YuanhuaHuang/status/1599768815017263104
#Senescence of Post-mitotic #Neuron🤓
Cortex ~1% non-demented Ctrl vs ~3% #AlzheimersDisease
Senescence spectrum of induced Neurons
Electrical defects
pro-astrogliosis SASP
Dr Joseph Herdy, Jerome Mertens & Fred Gage labs @CellStemCell 2022
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00457-X
10k steps/day physical activity (Garmin) for 6 mo Slow down enlargement rate of #AorticRoot (Echo) in #MarfanSyndrome
15 Ctrl 12 yr+24 Intervention 14 yr
0.13 vs -0.01 cm/yr 🤠
Dr. Elif S.S. Tierney lab JAHA 2022 @MarfanFdn
https://www.ahajournals.org/doi/10.1161/JAHA.122.027598
Can anyone rec papers on the normal growth rate of aorta dimension in healthy children/teenagers?🙏
Look at this gorgeous movie on Neutrophil (Green) talking with #EndothelialCell (Blue), #Pericyte (Magenta) & #MastCell (Cyan) in Venule during #Diapedesis 2 h post-TNFα challenge 🤩
Perivascular #MastCell IL-17A->
⏫MC-proximal venular #Pericyte/Mural cell (not #EndothelialCell) Surface presentation of ICAM1 & CXCL1->
⏫#Neutrophil #Diapedesis in subendothelial space
Dr. Mathieu-Benoit Voisin lab @NatureComms 2022 @RegisJoulia
https://www.nature.com/articles/s41467-022-34695-7
Hao Yin
boosted
RT @HaoYin20@twitter.com
A mind-blowing Science paper from Dr. Bin Zhou lab🤯
Genetically Labeling/Tracing Cell Contact events & post-contact consequences
Tigre-SynNotch + Cre & Dre transgenic🐭
One can track Ongoing+History of Contact (likely minimal 2-h) b/w 2 cell types
https://www.science.org/doi/10.1126/science.abo5503
Vascular #SmoothMuscleCell dysfunction in #Neurodegeneration
Vasculo-neuronal-inflammatory triad
Hypercontractile VSMC
⏬Clearance receptors for Aβ
Autoimmune-related SMC degeneration in #AlzheimersDisease
Dr. Genevieve Hayes lab @FrontNeurosci 2022
https://www.frontiersin.org/articles/10.3389/fnins.2022.1010164/full
Amazing developmental biologist🤩
Such a cell contact-tracking system is already taking shape in Drosophila as early as 2016!👍
Dr. Carlos Lois lab @JCellBiol
Monitoring cell-cell contacts in vivo in transgenic animals
Is there an even-earlier example!?😆
A mind-blowing paper from Dr. Bin Zhou lab🤯
Genetically Labeling/Tracing Cell Contact events & post-contact consequences
Tigre-SynNotch + Cre & Dre tri-transgenic🐭
One can track Ongoing+History of Contact (likely minimal 2-h) b/w any 2 cell types
Embryonic Cardiac #EndothelialCell not only constitutes 20% of Liver vessels but also colonizes Skeletal muscle (~5% Fig S11B)
How will this contact tracking system revolutionize our research?😄
Dendritic cell-> atherogenic SMC?
Senescent pericyte->Capillary shear sensing?
Hao Yin
boosted
An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
