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The latest from the lab spearheaded by @vijaykrishnarag: Cell derived matrices from bovine corneal endothelial cells as a model to study cellular dysfunction. @nationaleyeinstitute sciencedirect.com/science/arti

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Hi everyone👋 #preLights is a #preprint highlights service run by the biological #community and supported by #Co_Biologists allowing researchers to:

🔎 Sift through the growing volume of preprints.
💡 Highlight new thinking or new techniques across the biological sciences.
📝 Comment on preprints that are of particular interest.
👥 See comments and opinions of other researchers.

Toots from Reinier Prosée, the preLights community manager.

#Introduction #Biology #ECRs #Science #AcademicMastodon

12q, an optimized small chemical activator of
Comprehensive analyses vs MDL-800->
⏫Sirt6 deacetylase & demyristoylase activities
⏫Anti- activity

Look forward to more studies on its Non-tumoral benefits?🧐

Dr. Shengyong Yang lab J Med Chem 2022
pubs.acs.org/doi/full/10.1021/

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After scoping out Mastodon for about a week now, it's probably time for an #introduction

Hi I'm Alex, a Reviews #Editor for @Dev_journal, a community #journal covering #devbio, #stemcells & #regeneration. Development hosts the #devbiol community blog @the_node and is published by the @Co_Biologists.

I'll mostly be tooting about amazing #devbio research and conferences, and occasionally about personal stuff like #books, #reading, #gardening and other adventures on my bike or #kayak.

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#Introduction

Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.

We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.

Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown

Pancreatic Rab11a/Rab11b dKO->
Aberrant polarized transport of apical/basolateral proteins->
AMIS supernumerary->
Defects in ductal ; Acinar morphogenesis; Pancreatic cell lineage dysregulation

Highly intriguing, PancRab11KO->⏬Sox9+ bipotent progenitor & mass-> in suvived adult🐭

Lumenized epithelial paracrine or endocrine-autonomous defect?😆

No baseline change in fast glucose. Insulin/glucagon? Adult islet histology-Amyloid degeneration?

The branched, lumenized pancreatic duct is fragmented into disconnected Microlumens + enlarged Cyst in PancRab11KO🐭

Can't help but think Rab35 in anisotropic Lumenogenesis of liver

Is there a primary hydro-osmotic defect here?😋

Still, what happens to pancreatic vascular morphogenesis in Panc-Rab11 KO🐭?(Surely, epithelia & endothelia are coupled🤪)

More importantly, now it's the magic timing if you also want to have such amazing stories

Cleaver lab is recruiting TWO postdocs

Dr. Ondine Cleaver lab @ondinecleaver2022 bioXRiv 2022
biorxiv.org/content/10.1101/20

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Does anybody else find Mastodon to be buggy (slow)? I’m sure it’s the crush of people fleeing the bird site. But wondering if it’s just me.

(Also I realize the servers are maintained by volunteers and not a for-profit company, hence grateful, but curious).

Hao Yin boosted

Excited to share our preprint on the role of Rab11 in microlumen formation during early pancreas development.

When Rab11 is genetically deleted in pancreatic epithelium:
-intracellular cargo containing apically targeted proteins are stuck in the cell
-Lumens fail
-Branch morphogenesis is defective
-Beta cell mass is reduced

Cool work spearheaded by grad student Haley Barlow. #DevBio #DevBiol #Pancreas #BetaCell #Lumen #SendFeedback

biorxiv.org/content/10.1101/20

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🚨JOB ALERT🚨
My lab at University of Maryland-Baltimore is hiring a postdoc!

Consider applying if you are interested in cellular regulators of excitability #ionchannels, mouse brains🧠, CRISPR-Cas9 gene-editing 🧬✂️, and behaviors 🐭
(more info here: thejuarezlab.com)!

We are dedicated to the promotion of diversity and inclusivity in science.

We can also connect at #ACNP2022 in December!

#neuroscience #neurojobs #PDjob #URMinSTEM #BlackinNeuro #DSPAN #HHMIGilliam #NeuroMastodon

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RT @LyssiotisLab
Hyping new @SciImmunology from @_Hanna_Hong (before burns down 🔥)

➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment ⬅️

Read on for a
science.org/doi/10.1126/sciimm

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New insights on pancreatic morphogenesis from @ondinecleaver@ lab!

Another link between #morphogenesis and #differentiation!

Pre-print 🔗
qoto.org/@biorxivpreprint/1093

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Airway Inflammation

SMMHC-driven α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production

Dr. Mariam Ba lab FASEB Bioadv 2022
faseb.onlinelibrary.wiley.com/

Some encode functional peptides😎

LncPSR & its protein, Arteridin, complex with Ybx1->
contractile phenotype

AAV2-SM22α-shPSR⏬ANGII-induced SMC hypertrophy in🐭aorta

Dr. Y Wang, G Wu, C Zeng labs @CircRes 2022
ahajournals.org/doi/10.1161/CI

@sengerf

No idea yet. If I try it on skeletal muscle in the incoming month, I will update

😎

50% tetrahydrofuran in ddH2O to clear🐭🧠etc ≤ 48 h
80% Nycodenz+7M urea-> RI 1.518
Post-clearing cryosectionable, whole-mount immunofluorescence
Minimal volume change

Dr Chih-Wei Hsu & Joshua Wythe labs eLife 2022 @CWLoganHsu @wythelab
elifesciences.org/articles/774

Landmark👹

How fetal liver vasculature serves as a transient niche for expansion while undergoing

Fetal liver hematopoietic stem cell niches associate with portal vessels

Dr. Paul Frenette lab Science 2015
science.org/doi/10.1126/scienc

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