The latest from the lab spearheaded by @vijaykrishnarag: Cell derived matrices from bovine corneal endothelial cells as a model to study cellular dysfunction. #ophthalmology #cornea @nationaleyeinstitute https://www.sciencedirect.com/science/article/abs/pii/S0014483522003840?via%3Dihub
Hi everyone👋 #preLights is a #preprint highlights service run by the biological #community and supported by #Co_Biologists allowing researchers to:
🔎 Sift through the growing volume of preprints.
💡 Highlight new thinking or new techniques across the biological sciences.
📝 Comment on preprints that are of particular interest.
👥 See comments and opinions of other researchers.
Toots from Reinier Prosée, the preLights community manager.
12q, an optimized small chemical activator of #Sirt6
Comprehensive analyses vs MDL-800->
⏫Sirt6 deacetylase & demyristoylase activities
⏫Anti-#PancreaticDuctalAdenoCarcinoma activity
Look forward to more studies on its Non-tumoral benefits?🧐
Dr. Shengyong Yang lab J Med Chem 2022
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.0c01183
After scoping out Mastodon for about a week now, it's probably time for an #introduction
Hi I'm Alex, a Reviews #Editor for @Dev_journal, a community #journal covering #devbio, #stemcells & #regeneration. Development hosts the #devbiol community blog @the_node and is published by the @Co_Biologists.
I'll mostly be tooting about amazing #devbio research and conferences, and occasionally about personal stuff like #books, #reading, #gardening and other adventures on my bike or #kayak.
Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.
We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.
Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown
Pancreatic Rab11a/Rab11b dKO->
Aberrant polarized transport of apical/basolateral proteins->
AMIS supernumerary->
Defects in ductal #Lumenogenesis; Acinar morphogenesis; Pancreatic cell lineage dysregulation
Highly intriguing, PancRab11KO->⏬Sox9+ bipotent progenitor & #Islet mass-> #GlucoseIntolerance in suvived adult🐭
Lumenized epithelial paracrine or endocrine-autonomous defect?😆
No baseline change in fast glucose. Insulin/glucagon? Adult islet histology-Amyloid degeneration?
The branched, lumenized pancreatic duct is fragmented into disconnected Microlumens + enlarged Cyst in PancRab11KO🐭
Can't help but think Rab35 in anisotropic Lumenogenesis of liver #BileCanaliculi
Is there a primary hydro-osmotic defect here?😋
Still, what happens to pancreatic vascular morphogenesis in Panc-Rab11 KO🐭?(Surely, epithelia & endothelia are coupled🤪)
More importantly, now it's the magic timing if you also want to have such amazing stories
Cleaver lab is recruiting TWO postdocs
Dr. Ondine Cleaver lab @ondinecleaver2022 bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.17.516976v1
Excited to share our preprint on the role of Rab11 in microlumen formation during early pancreas development.
When Rab11 is genetically deleted in pancreatic epithelium:
-intracellular cargo containing apically targeted proteins are stuck in the cell
-Lumens fail
-Branch morphogenesis is defective
-Beta cell mass is reduced
Cool work spearheaded by grad student Haley Barlow. #DevBio #DevBiol #Pancreas #BetaCell #Lumen #SendFeedback
The small RNA landscape is stable with age in Drosophila
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273590
🚨JOB ALERT🚨
My lab at University of Maryland-Baltimore is hiring a postdoc!
Consider applying if you are interested in cellular regulators of excitability #ionchannels, mouse brains🧠, CRISPR-Cas9 gene-editing 🧬✂️, and behaviors 🐭
(more info here: https://thejuarezlab.com)!
We are dedicated to the promotion of diversity and inclusivity in science.
We can also connect at #ACNP2022 in December!
#neuroscience #neurojobs #PDjob #URMinSTEM #BlackinNeuro #DSPAN #HHMIGilliam #NeuroMastodon
RT @LyssiotisLab
Hyping new @SciImmunology from @_Hanna_Hong (before #Twitter burns down 🔥)
➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment ⬅️
Read on for a #tweetorial
http://www.science.org/doi/10.1126/sciimmunol.abm8182
New insights on pancreatic morphogenesis from @ondinecleaver@ lab!
Another link between #morphogenesis and #differentiation!
Pre-print 🔗
https://qoto.org/@biorxivpreprint/109366467608301665
Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. https://www.biorxiv.org/content/10.1101/2022.11.17.516976v1?med=mas
#cardiology #CardioTooter Future in medicine : Inflammosomes .Targeting the Inflammasome in Cardiovascular Disease
https://www.jacc.org/doi/full/10.1016/j.jacbts.2021.08.006
Airway #SmoothMuscleCell #Asthma Inflammation
SMMHC-driven #Integrin α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production
Dr. Mariam Ba lab FASEB Bioadv 2022
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2022-00050
Some #LongNonCodingRNAs encode functional peptides😎
LncPSR & its protein, Arteridin, complex with Ybx1->
⏬#SmoothMuscleCell contractile phenotype
AAV2-SM22α-shPSR⏬ANGII-induced SMC hypertrophy in🐭aorta
Dr. Y Wang, G Wu, C Zeng labs @CircRes 2022
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321080
No idea yet. If I try it on skeletal muscle in the incoming month, I will update
50% tetrahydrofuran in ddH2O to clear🐭🧠etc ≤ 48 h
80% Nycodenz+7M urea-> RI 1.518
Post-clearing cryosectionable, whole-mount immunofluorescence
Minimal volume change
Dr Chih-Wei Hsu & Joshua Wythe labs eLife 2022 @CWLoganHsu @wythelab
https://elifesciences.org/articles/77419
Landmark👹
How fetal liver vasculature serves as a transient niche for #HematopoieticStemCell expansion while undergoing #BranchingMorphogenesis
Fetal liver hematopoietic stem cell niches associate with portal vessels
Dr. Paul Frenette lab Science 2015
https://www.science.org/doi/10.1126/science.aad0084
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op