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Hao Yin boosted
Joachim Goedhart

Recent work by Max Gronloh and @twitter@VanBuul_lab on hotspots for transendothelial migration made it to the cover - seems appropriate for #FluorescenceFriday
Read the full story here:
embopress.org/doi/full/10.1525

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Hao Yin boosted
Theory of Living Matter Group

RT @SugimuraLab
@CurrentBiology @YoichiroTamori We thank @tetsuotani1, @bellaiche_y and Philippe Marcq for critical reading of the manuscript.

Free access link, which is active until February 08, 2023:
authors.elsevier.com/a/1gHZX3Q

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Hao Yin

MEG9/Mirg, a LncRNA in Dlk1-Dio3 cardio-angiocluster, links &
⏫by Genotoxic stress
⏬by VEGF/FGF2/Dll4/Jag1

🐭Mirg KO affects s.c. Matrigel vessel stability in a Sex-specific manner

Dr. Cristina Espinosa-Diez & Sudarshan Anand lab bioRXiv 2022
biorxiv.org/content/10.1101/20

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Hao Yin

with Bizarre Nuclei: A Current Update

Review on Uterine Smooth Muscle Tumors😎

Pathology & MRI

Differentiating LBN from
other Leiomyoma
USMT of uncertain malignant potential Leiomyosarcoma

Dr. Q Zheng & L Wang labs Int J Womens Health 2022
dovepress.com/leiomyoma-with-b

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Hao Yin

Sirt6⏬ & IL15-JAK3-STAT5-inflammation in adult

Deacetylated STAT5 by Sirt6 fails nuclear import

In contrast, Sirt6⏫p21->Senescence in embryonic chondrocyte

Dr. Ming-liang Ji & Jun Lu lab Nature Comms 2022
nature.com/articles/s41467-022

An interesting chondrotrophic nanoparticle is used to deliver MDL-800, Sirt6 activator, in🐭DMM

Chondrocyte-specific aptamer tgg2-functionalized PEGylated PAMAM nanoparticle

Originally used for microRNA Annals of the Rheumatic Diseases 2021
ard.bmj.com/content/80/3/356.a

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Hao Yin boosted
zeinab rekad, PhD

RT @lucasmpinto
Please RT. My graduate student Peter Salvino @petersalvino has been missing since last night. Last seen in Lincoln Park, Chicago. See below. Please get in touch if you have any info

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Hao Yin boosted
Francoise Helmbacher

New Call: The #IBDM (Institute of Developmental Biology of Marseille) invites applications for Group leader positions

Deadline for application March 1st, 2023

#DevBio #DevBiol #CNRS #AMU

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Hao Yin

Vascularization improves function performance of -β Islet 🤠

Ca2+ as a surrogate for insulin secretion to high throughput screening

A role of signaling &

Dr. Maike Sander lab bioRxiv 2022
biorxiv.org/content/10.1101/20

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Hao Yin boosted
Casey Greene

I'm excited about this new #genomics #scRNA #rnaseq preprint from @ariel_hippen! It's a molecular biology deep dive into what happens when you dissociate and single-cell sequence a tissue with the goal of performing deconvolution of bulk tissue.

Some key bits: there are dissociation effects, RNA capture/depletion effects, and potentially some microfluidics effects with the #10X platform. Also, deconvolution algorithms are variably robust to these things.

See more:
biorxiv.org/content/10.1101/20

1+
Hao Yin

The lysosomal degraders

+derivatives

An update on Research & Commercialization of for targeted protein degradation

"LYTACs, ATACs, AbTACs, KineTACs, PROTABs, AUTACs, ATTECs and AUTOTACs"

Ken Garber Nature Biotech 2022
nature.com/articles/s41587-022

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Hao Yin

🐭 Heart

Spatiotemporal YAP nuclear patterning in Valvular Endothelium+Interstitium correlates with in vivo force transition
⏬by
⏫by OSS
⏫by
⏬by

Jonathan Butcher Lab bioRxiv 2022
biorxiv.org/content/10.1101/20

0
Hao Yin boosted
Theory of Living Matter Group

RT @G_Charras
How do cells orient their division within the epithelial plane?

We find that a sufficiently large tension at junctions is required for accurate in plane division.

doi.org/10.1073/pnas.220160011

Great work by @ana_lisica @jduquell @alebonfanti_ab @womtyatt @manasikelkar09 @BaumBuzz

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Hao Yin

Pathogenesis of with focus on cellular populations

Immune+Stromal cell dynamics

Cytokine signature
IL6-IL17
IL12-IFNγ

Immune Checkpoint

Immunosenescence

This is a very friendly review for a non-immunologist (me😄)

Dr. Pavlos Stamatis lab Front Medicine 2022
frontiersin.org/articles/10.33

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Hao Yin

An autosomal (Chr2) Myh11-CreERT2🐭model to enable -specific KO & lineage tracing in Both MALE & FEMALE!👍

Previous mouse Myh11-Cre transgenes are Y-linked

Dr. Gary Owens lab ATVB 2022
ahajournals.org/doi/10.1161/AT

0
Hao Yin

to image Left Ventricle flow components & LA-LV local pressure in with mild + preserved ejection fraction

51 BAV vs 24 Ctrl

Dr. Julio Garcia lab Front Carduivasc Medicine 2022
frontiersin.org/articles/10.33

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Hao Yin boosted
Theory of Living Matter Group

RT @rulandsgroup
Lineage tracing experiments are often compromised by the merging and fragmentation of clones. Together with @YitengDang we wrote a review summarising statistical strategies to detect and resolve such non-clonality. frontiersin.org/articles/10.33

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Hao Yin boosted
Theory of Living Matter Group

RT @YEN_community
📢 Save the date! 📢 #YEN2023 will be a hybrid event at @thecrick on the 22nd of May 2023. We are thrilled to have @kaessmannlab @PauliGroup @Mad_Lancaster and #KatsuhikoHayashi as invited speakers. More details soon youngembryologists.org/ 😊

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Hao Yin

Take a look at this amusing repair of 2-photon vessel injury by 2 adjacent

Dr Karen Hirschi & Valentina Greco labs bioRxiv 2022
biorxiv.org/content/10.1101/20

0
Hao Yin

Diabetic Retinal Vasculopathy in

5%-0% glucose alternating per 12 h for 30 d

⏫Vessel diameter
⏬ZO-1 tight junction
⏬SM22α+ mural cell coverage

Changes in other vascular beds?🧐

Dr. Cheol-Hee Kim & Seung-Hyun Jung labs IJMS_MDPI 2022
mdpi.com/1422-0067/23/23/15069

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Hao Yin

IL-1β & Macrophage-like /SMC-derived

scRNAseq👤calcified (proximal vs core)->
Ligand-SMC receptor map + Mɸ-like SMC transcription network->
⏫IL1β-⏬STAT3

AAV9-Cas9-sgIL1β for🐭

Dr. Suxin Luo lab Comms Bio 2022
nature.com/articles/s42003-022

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