Recent work by Max Gronloh and @twitter@VanBuul_lab on hotspots for transendothelial migration made it to the cover - seems appropriate for #FluorescenceFriday
Read the full story here:
https://www.embopress.org/doi/full/10.15252/embr.202255483
RT @SugimuraLab
@CurrentBiology @YoichiroTamori We thank @tetsuotani1, @bellaiche_y and Philippe Marcq for critical reading of the manuscript.
Free access link, which is active until February 08, 2023:
https://authors.elsevier.com/a/1gHZX3QW8R%7EfcY
MEG9/Mirg, a LncRNA in Dlk1-Dio3 cardio-angiocluster, links #DNADamage & #Angiogenesis
⏫by Genotoxic stress
⏬by VEGF/FGF2/Dll4/Jag1
🐭Mirg KO affects s.c. Matrigel vessel stability in a Sex-specific manner
Dr. Cristina Espinosa-Diez & Sudarshan Anand lab bioRXiv 2022
https://www.biorxiv.org/content/10.1101/2022.12.07.519382v1
#Leiomyoma with Bizarre Nuclei: A Current Update
Review on Uterine Smooth Muscle Tumors😎
Pathology & MRI
Differentiating LBN from
other Leiomyoma
USMT of uncertain malignant potential Leiomyosarcoma
Dr. Q Zheng & L Wang labs Int J Womens Health 2022
https://www.dovepress.com/leiomyoma-with-bizarre-nuclei-a-current-update-peer-reviewed-fulltext-article-IJWH
Sirt6⏬#Senescence & IL15-JAK3-STAT5-inflammation in adult #Chondrocyte
Deacetylated STAT5 by Sirt6 fails nuclear import
In contrast, Sirt6⏫p21->Senescence in embryonic chondrocyte
Dr. Ming-liang Ji & Jun Lu lab Nature Comms 2022
https://www.nature.com/articles/s41467-022-35424-w
An interesting chondrotrophic nanoparticle is used to deliver MDL-800, Sirt6 activator, in🐭DMM #Osteoarthritis
Chondrocyte-specific aptamer tgg2-functionalized PEGylated PAMAM nanoparticle
Originally used for microRNA Annals of the Rheumatic Diseases 2021
https://ard.bmj.com/content/80/3/356.abstract
Vascularization improves function performance of #hiPSC-β Islet #Organoid 🤠
Ca2+ as a surrogate for insulin secretion to high throughput screening
A role of #Angiocrine #BMP4 signaling & #BasementMembrane
Dr. Maike Sander lab bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.10.28.513298v1.full
I'm excited about this new #genomics #scRNA #rnaseq preprint from @ariel_hippen! It's a molecular biology deep dive into what happens when you dissociate and single-cell sequence a tissue with the goal of performing deconvolution of bulk tissue.
Some key bits: there are dissociation effects, RNA capture/depletion effects, and potentially some microfluidics effects with the #10X platform. Also, deconvolution algorithms are variably robust to these things.
See more:
https://www.biorxiv.org/content/10.1101/2022.12.04.519045v1
The lysosomal degraders
#PROTAC +derivatives
An update on Research & Commercialization of #MolecularGlue for targeted protein degradation
"LYTACs, ATACs, AbTACs, KineTACs, PROTABs, AUTACs, ATTECs and AUTOTACs"
Ken Garber Nature Biotech 2022
https://www.nature.com/articles/s41587-022-01594-7
#Mechanobiology🐭 Heart #Valvulogenesis
Spatiotemporal YAP nuclear patterning in Valvular Endothelium+Interstitium correlates with in vivo force transition
⏬by #LaminarShearStress
⏫by OSS
⏫by #CompressiveStress
⏬by #TensileStress
Jonathan Butcher Lab bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.24.517814v1.full
RT @G_Charras
How do cells orient their division within the epithelial plane?
We find that a sufficiently large tension at junctions is required for accurate in plane division.
https://doi.org/10.1073/pnas.2201600119
Great work by @ana_lisica @jduquell @alebonfanti_ab @womtyatt @manasikelkar09 @BaumBuzz
Pathogenesis of #GiantCellArteritis with focus on cellular populations
Immune+Stromal cell dynamics
Cytokine signature
IL6-IL17
IL12-IFNγ
Immune Checkpoint
Immunosenescence
This is a very friendly review for a non-immunologist (me😄)
Dr. Pavlos Stamatis lab Front Medicine 2022
https://www.frontiersin.org/articles/10.3389/fmed.2022.1058600/full
An autosomal (Chr2) Myh11-CreERT2🐭model to enable #SmoothMuscleCell-specific KO & lineage tracing in Both MALE & FEMALE!👍
Previous mouse Myh11-Cre transgenes are Y-linked
Dr. Gary Owens lab ATVB 2022
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318160
#4DFlowMRI to image Left Ventricle flow components & LA-LV local pressure in #BicuspidAorticValve with mild #AorticRegurgitation + preserved ejection fraction
51 BAV vs 24 Ctrl
Dr. Julio Garcia lab Front Carduivasc Medicine 2022
https://www.frontiersin.org/articles/10.3389/fcvm.2022.903277/full
RT @rulandsgroup
Lineage tracing experiments are often compromised by the merging and fragmentation of clones. Together with @YitengDang we wrote a review summarising statistical strategies to detect and resolve such non-clonality. https://www.frontiersin.org/articles/10.3389/fcell.2022.1054476/full
RT @YEN_community
📢 Save the date! 📢 #YEN2023 will be a hybrid event at @thecrick on the 22nd of May 2023. We are thrilled to have @kaessmannlab @PauliGroup @Mad_Lancaster and #KatsuhikoHayashi as invited speakers. More details soon http://www.youngembryologists.org/ 😊
Take a look at this amusing repair of 2-photon vessel injury by 2 adjacent #EndothelialCells
Dr Karen Hirschi & Valentina Greco labs bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.02.514907v1.full
Diabetic Retinal Vasculopathy in #Zebrafish
5%-0% glucose alternating per 12 h for 30 d
⏫Vessel diameter
⏬ZO-1 tight junction
⏬SM22α+ mural cell coverage
Changes in other vascular beds?🧐
Dr. Cheol-Hee Kim & Seung-Hyun Jung labs IJMS_MDPI 2022
https://www.mdpi.com/1422-0067/23/23/15069⏬
IL-1β & Macrophage-like #SmoothMuscleCell/SMC-derived #FoamCell
scRNAseq👤calcified #Atherosclerosis (proximal vs core)->
Ligand-SMC receptor map + Mɸ-like SMC transcription network->
⏫IL1β-⏬STAT3
AAV9-Cas9-sgIL1β for🐭
Dr. Suxin Luo lab Comms Bio 2022
https://www.nature.com/articles/s42003-022-04255-2
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op