Focal adhesions help endothelial cells get in line
A Research Highlight showcasing new work from Tevin Chau, Anne Lagendijk and colleagues
https://journals.biologists.com/dev/article/149/23/e149_e2302/285925/Focal-adhesions-help-endothelial-cells-get-in-line
We interviewed the authors of the paper, Tevin Chau and Anne Lagendijk, for our 'The people behind the papers' series.
https://journals.biologists.com/dev/article/149/23/dev201441/285916/The-people-behind-the-papers-Tevin-Chau-and-Anne
Read the full #OpenAccess Research Article, ‘Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature’ here: https://journals.biologists.com/dev/article/149/23/dev200454/285926/Dynamically-regulated-focal-adhesions-coordinate
Smoking and progressive retinal nerve fibre layer thinning in glaucoma
https://bjo.bmj.com/content/early/2022/09/13/bjo-2022-321237
In #BicuspidAorticValve #Aortopathy, #Aorta-enriched plasma cell-free DNA methylation correlated with ascending aortic #Apoptosis in regions of elevated #WallShearStress (4D flow MRI), but Not aortic diameter
An interesting method to identify tissue-enriched DNA methylation in this paper
Roadmap Epigenomics
BluePrint Epigenome
Metilene
https://www.bioinf.uni-leipzig.de/Software/metilene/
24 candidate aorta-enriched differentially methylated regions
4 used in this study
Dr. Steven Greenway lab Clin Epigenetics 2021
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01137-y
RT @VeniceEvoDevo
Venice Evo Devo Summer School 2023: The Future of Evo-Devo
August 21-25, 2023
Centro Cultural Don Orione Artigianelli, Venice
Registration at:
https://meetings.embo.org/event/23-evolution-venice
Check out our amazing line-up!
Deadline is March 31, 2023.
@EMBOevents
#EMBOevoDevoSystems
#VeniceEvoDevo
Splendid #SciArt by Kristy Red-Horse lab
Endocardial Origin of Coronary #EndothelialCell +Arteriogenesis
A fascinating BMP2+ transitioning e17.5 coronary EC population
How EC & nonvascular BMPs coordinate heart #Angiogenesis😆
Exogenous BMP2 synergizes with VEGF-A⏫endocardial-derived Angiogenic sprouting from e10.5🫀ventricle explants
LDN193189, BMPR inhibitor,⏬endocardial contribution to coronary vascularization
AAV9-cTnt-Bmp2⏫endocardial-derived angiogenesis in neonatal #MyocardialInfarction🤠
Dev Cell 2022 @kristyredhorse
https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00759-6
'Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture'
#DevBio
https://www.biorxiv.org/content/10.1101/2022.12.12.519937v1
ApoE KO🐶♂️normal diet 18 mo
Multi-arterial #Atherosclerosis->
MI/Stroke/Gangrene
scRNAseq athero-prone vs -resistant arteries
#TenascinC+ #SmoothMuscleCell - LTBP1+ myofibroblast transition in atherogenesis
Dr. X. Wang, YB Zhang, X Ji labs Aging Dis 2022
http://www.aginganddisease.org/EN/10.14336/AD.2022.0313
Lecturer in Molecular Genetics (Learning, Teaching & Scholarship) @UofGSMB@twitter.com @UofGMVLS@twitter.com open for applications, closing date 30 January 2023. Full-time post, Grade 7, for 2 years.
Great colleagues superb students, great University!
https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.jobspec?p_id=104150
From our colleagues in Copenhagen. FKBP2 and it’s role in insulin processing.
RT @quantumjot
🚨JOB ALERT: We have multiple new postdoc positions at @turinginst to develop #ComputerVision and #MachineLearning methods for #bioimageanalysis and more. Join an awesome team and explore the use of #AI for science.🚀Please RT.
DEADLINE: 5th Jan 2023
https://cezanneondemand.intervieweb.it/turing/jobs/research-associate-computer-vision-29069/en/
#Sirt6 control of #EndothelialCell #FattyAcid transport links #Diabetes microvascular dysfunction with #HeartFailurewithPreservedEjectionFraction #HFpEF
EC Sirt6->
⏬H3K9ac PPARγ promoter
⏬CD36,FABP4/5
⏬🐭 Heart Lipid
Dr. Zheng Gen Jin lab Circ Res 2022
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318988
#Autophagy in🐭#LimbIschemia 1/2
AMPK or Sestrin as potential autophagic regulators
Dr. Mattia Scalabrin & Scott Bowen lab AJP CellPhys 2022
https://journals.physiology.org/doi/abs/10.1152/ajpcell.00174.2022
Which tissue does autophagy occur in (likely #SkeletalMuscle based on Western blot)? And its functional impacts?
#Autophagy in🐭#LimbIschemia 2/2
Evidence on autophagy induced by ischemia/#Hypoxia in #EndothelialCell, and its stimulatory effects on #Angiogenesis
Dr. Joo-Won Jeong lab Cell Death Dis 2020
https://www.nature.com/articles/s41419-020-02849-4
RT @BardinLab
Come join us for an exciting meeting on Growth, Regeneration, and Aging in Roscoff, France, May 22-26, 2023!
https://www.insb.cnrs.fr/fr/growth-and-regeneration-during-development-and-aging
ICAM1-hi #EndothelialCell form Hotspots for #Neutrophil #TransEndothelialMigration (Paracellular)
Blunting ICAM1 heterogeneity
⏬TEM hotspots
⏫TEM-associated endothelial Permeability
Dr. Jaap van Buul lab @emboreports 2022 @joachimgoedhart @VanBuul_lab
https://www.embopress.org/doi/full/10.15252/embr.202255483
Impossible to make a better presentation on this great paper than first-author Max Grönloh @GronlohMax 👇
Also don't miss the informative Discussion session synthesizing the signaling networks of leukocyte TEM
Congratulations!👏👏👏
Apold1, a #EndothelialCell-enriched gene, in pathological #Angiogenesis
#LimbIschemia ⏬Reperfusion (3 dpi🤓)-> An arteriogenic defect?
#Stroke ⏫border zone vascularization at day 21 but not day 7
Tumor ⏫Nonproductive angiogenesis-> more non-perfusable endothelial channels
Apold1 KO⏬EC Proliferation-How😁
@bohaceklab@nerdculture.de & Katrien de Bock bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.12.02.518829v1
Also very interesting, Apold1 KO->⏫KLF2 & KLF4 in EC
Apold1 is recently identified as an ascending aortic EC-enriched gene (vs descending aorta/carotid artery)
Dr. Thomas Quertermous lab bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.05.18.492517v1.full
Are Apold1 KO mice ready for #Atherosclerosis/#Aneurysm?
Venous #EndothelialCell as #Angiogenesis origin in🐭#EAE #MultipleSclerosis
Blocking VEGFA (Bevacizumab 7 dpi)
⏬Aberrant angiogenesis
⏫Myelination+neuromotor
BUT w/o altering Immune cell infiltration or Endothelial Barrier (IgG)😎
Dr. Dritan Agalliu lab bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.15.516660v1
Quick question for the Drosophila aficionados :) have ever come across with a suppressor of the dominant mutation IF? I have a IF/Cyo stock and everything is ok exempt that the IF eye ia gone :) i gave seen Tb disappear from a TM6b (where Hu is still around), but never had IF vanishing into oblivion… just curious….
The amoeboid state as part of the epithelial-to-mesenchymal transition programme #EMT
Linking cell Shape control, Cytokine signaling with Cancer Stemness & Malignancy🤠
Dr. Victoria Sanz-Moreno lab @TrendsCellBio 2022
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00206-3
I add three more protocols to my book on data visualization in R/ggplot2 for wet lab scientists.
Protocol 13 explains how to plot multiple plots side-by-side.
Find all protocols here: https://joachimgoedhart.github.io/DataViz-protocols/
#Photosynthesis in🐭#Chondrocyte👹
#Biocamouflage
-Use target cell membrane to encapsulate🍃NanoThylakoid Units & evade cross-species elimination
-Supply ATP+NADPH for days in recipient cells
Intra-articular injection🐭causes no overt #ForeignBodyReaction🥸
Metabolic profiles of Chondrocytes+Thylakoids🤠
Dr. Ruikang Tang, Shunwu Fan & Xianfeng Lin labs Nature 2022
https://www.nature.com/articles/s41586-022-05499-y
Photosynthetic medicine for #Osteoarthritis
A lay summary👇
Plant-cell machinery for making metabolites transferred to mammalian cells
https://www.nature.com/articles/d41586-022-03629-0
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op