For #FluorescenceFriday, here is an #HHMIJanelia FlyLight #Drosophila Split-GAL4 volume (LH2041) in magenta, with a matching FLyEM Hemibrain V1.2.1 skeleton (LHPV12a1, 480590566) in green. The match was found by the color-depth search algorithm of Hideo Otsuna, Masayoshi Ito, and Takashi Kawase running in the NeuronBridge system (https://neuronbridge.janelia.org). Volume rendering in NeuronBridge is interactive, so in addition to this view...(1/5)
We have an opportunity for an outstanding scientist to establish their research group at the Perutz. The successful candidate will be offered an #assistantprofessor position at the Medical University of Vienna. Read more: https://tinyurl.com/4hjm863y #sciencjobs #facultyjobs #academicjobs
Across scales: our neuronal cultures (🔬 top) and the distribution of dark matter in the universe (🔭 bottom)
RT @CNRS@twitter.com
#CNRSleJournal 📰 Quels sont les liens entre l’infiniment petit et l’infiniment grand ? Comment les briques fondamentales de la matière s’assemblent-elles pour former des étoiles, des galaxies ou des trous noirs ? Tout juste paru, le livre "Étonnants ... https://bit.ly/3EXOIqP
Honored to be awarded the Alexander von Humboldt professorship with Physics of Life (@PoLDresden) at TU Dresden (@tudresden_de)!
This means that I will start building a new lab in PoL/TU Dresden, Germany next spring. My group will also have a space at Max Planck CBG (@mpicbg). 1/
Decoupling #TGFβ1 with phospho-SMAD2 (S457) & phospho-SMAD3 (S423/425) in ascending #AorticAneurysm with #BicuspidAorticValve or #UnicuspidAorticValve
How about TGFβ2/3?
As a comparison, in #TricuspidAorticValve aorta, diameter and elastin break correlate well with increased TGFβ1 level or p-SMAD2/3 levels
Dr. Brittany Balint & Hans-Joachim Schäfers lab, Sci Rep 2022
https://www.nature.com/articles/s41598-022-19335-w
Airway #SmoothMuscleCell forms Collagen III microniche⏫🫁#Metastasis of #BladderCancer
via DDR1-HSP90-Stat3 axis
In primary #MuscleInvasiveBladderCarcinoma Collagen I-DDR1 axis⏫tumor invasiveness
Dr. Keith Syson Chan lab Nature Comms 2019
https://www.nature.com/articles/s41467-019-09878-4
Sea star single-cell sequencing shines light on germ cell specification
A Research Highlight showcasing new work from Stephany Foster, Gary Wessel and colleagues
Read the full Techniques and Resources article, ‘Single-cell RNA-sequencing analysis of early sea star development’ here:
AORTA score, a predictive model trained +common features (age/sex/BP...) in >30k #UKBiobank👤 explains 28-33% #AscendingAorticDiameter
Dr. James Pirruccello
Dr. Mark Lindsay @MarkELindsay Dr. Patrick Ellinor
JAMA 2022
https://jamanetwork.com/journals/jama/article-abstract/2798406
Enjoy the great🧵 by Dr. James Pirruccello
https://twitter.com/jpirruccello/status/1592596235751665666
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis
RT @GRC_CMM
Hey #cilia & #centriole tweeps- we are just under two weeks from our deadline ⏳December 5th⏳ for abstracts for talk slots at 2023 GRC Cilia, Mucus and Mucociliary meeting in Barga, Italy! #RareDisease #Therapeutics #Biophysics #Biofilms #Mucus #CF #PCD https://www.grc.org/cilia-mucus-and-mucociliary-interactions-conference/2023/
Abdominal Aortic Calcification in #UKBiobank
38264👤
#MachineLearning to measure AAC
-Physio/Biochem predictors
-Cardiovascular outcomes
-Genetics TWIST1/HDAC9, FGF9, NAV1, APOE
Dr. Madeleine Cule & Eugene Melamud lab Frontiers Cardiovascular Medicine 2022
https://www.frontiersin.org/articles/10.3389/fcvm.2022.1003246/full
Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro
An #OpenAccess T&R article from Oleksandr Kirsanov, Christopher Geyer and colleagues
This article is available under our Read & Publish Open Access initiative.
Researchers can find out about the benefits, read what researchers are saying and view a list of participating institutions at https://www.biologists.com/library-hub/read-publish/researchers/
Hi #ScienceMastodon. Have you already seen the latest post @preLights? 📜
It has been written by #AarrenMannion #KarolinskaInstitutet who covers the #preprint from the lab of Anne-Clémence Vion working at the #InstitutThorax. In this work, the team of researchers show the importance of the guanine nucleotide exchange factor, ARHGEF18, in regulating endothelial cell alignment in the direction of flow. 🌊
Hi #MedMastodon! 👋
#Introduction: I'm an #Endocrinologist at #Stanford, specializing in #Osteoporosis and #MetabolicBoneDisease. My lab studies #StemCells in bone 🦴 and the bone marrow microenvironment.
Some of my favorite topics: #WomenInMedicine #WomenInSTEM #PhysicianScientists #AAPI
I guess I should introduce myself #onhere: I am a postdoc in the Schier Lab at the Biozentrum (Switzerland). I am using #zebrafish to understand the #development of the nervous system. I love developmental biology of classic and non-canonical organisms, microscopy, loud music and comic books. Very much looking forward to meeting other scientists and cool people!
PS: I also help co-managing @ZebrafishRock , so make sure to give them a follow for the latest zebrafish community news
Evidence on #EndMT in human #MultipleSclerosis
Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction & occurs during multiple sclerosis pathophysiology
Dr. Helga de Vries lab Cell Death Dis 2019
https://www.nature.com/articles/s41419-018-1294-2
#EndothelialCell ARF6 GTPase links IL-1β inflammation with TGFβ/BMP-SMAD1/5 #EndMT
EC Arf6 KO in🐭#EAE->
⏫#BBB #BloodSpinalCordBarrier
⏬T cell infiltration & demyelination
w/o altering normal immunity
Dr. Shannon Odelberg, Weiquan Zhu labs Neuron 2022
https://www.sciencedirect.com/science/article/pii/S0896627322006602
Issue 21 is complete!
On the cover is a 3D surface rendering of a lung lobe from a mouse #embryo, showing the relationship between the arterial network (red) and the lung epithelium (grey) from Chandrasekaran et al.
Also in Issue 21:
- 8 #Research Highlights
- In #preprints article on reconstituting the ovary
- Ruth Bellairs obituary
- 2 author interviews
- Poster & article on resolving #morphogenesis into quantifiable cell behaviours
- Nuclear movement Review
Meet the #preLighters: Chee Kiang (Ethan) Ewe. 🌟
https://prelights.biologists.com/news/meet-the-prelighters-a-virtual-chat-with-chee-kiang-ethan-ewe/
Ethan is a #postdoc in the lab of @Odedrechavi at Tel Aviv University, Israel, where he studies the molecular basis of epigenetic #inheritance.
We spoke about his very international #career, the #mentors along the way, his future #goals, and the importance of #preprints both to him and the biological #community.
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op