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Hao Yin boosted
DaveFinlayTCD

RT @LyssiotisLab
Hyping new @SciImmunology from @_Hanna_Hong (before burns down 🔥)

➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment ⬅️

Read on for a
science.org/doi/10.1126/sciimm

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Hao Yin boosted
SpagnoliLab

New insights on pancreatic morphogenesis from @ondinecleaver@ lab!

Another link between #morphogenesis and #differentiation!

Pre-print 🔗
qoto.org/@biorxivpreprint/1093

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Hao Yin boosted
bioRxiv

Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. biorxiv.org/content/10.1101/20

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Hao Yin

Airway Inflammation

SMMHC-driven α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production

Dr. Mariam Ba lab FASEB Bioadv 2022
faseb.onlinelibrary.wiley.com/

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Hao Yin

Some encode functional peptides😎

LncPSR & its protein, Arteridin, complex with Ybx1->
⏬ contractile phenotype

AAV2-SM22α-shPSR⏬ANGII-induced SMC hypertrophy in🐭aorta

Dr. Y Wang, G Wu, C Zeng labs @CircRes 2022
ahajournals.org/doi/10.1161/CI

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Hao Yin

😎

50% tetrahydrofuran in ddH2O to clear🐭🧠etc ≤ 48 h
80% Nycodenz+7M urea-> RI 1.518
Post-clearing cryosectionable, whole-mount immunofluorescence
Minimal volume change

Dr Chih-Wei Hsu & Joshua Wythe labs eLife 2022 @CWLoganHsu @wythelab
elifesciences.org/articles/774

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Hao Yin

Landmark👹

How fetal liver vasculature serves as a transient niche for expansion while undergoing

Fetal liver hematopoietic stem cell niches associate with portal vessels

Dr. Paul Frenette lab Science 2015
science.org/doi/10.1126/scienc

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Hao Yin boosted
Kristin Knouse

Thrilled to share our lab's first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.

cell.com/cell-genomics/fulltex

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Hao Yin


Next-gen

activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭+

Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
nature.com/articles/s41586-022

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Hao Yin boosted
ergyrase

@ondinecleaver2022 @DenisDuboule @opourquie @mads100tist @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @Mill_lab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot @MarieKmita

Few additions if not overlapping:
@DavidBrueckner (who actually helped many of us to join mastodon!)
@edouardhannezo
@MikiEbisuya
And @knoepfler is here, and was looking for exactly this kind of thread the other day

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Hao Yin

~50% Olig2+ Progenitors migrate along blood vessel in prenatal🧠cortex🤠

Vessel-guided migration favors superficial cortex as Astrocyte destination

CXCL12-> AP CXCR4/7

Dr. Hidenori Tabata & Kazunori Nakajima labs Nat Comm 2022
nature.com/articles/s41467-022

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Hao Yin

Pulmonary

Hypoxia
6 dyn/cm2
Patient ECFC+HPASMC co-culture

BMPR2-Sox17->
Prostacyclin production->
⏬ proliferation

Comparative transcriptomics vs PAH gene sets

Dr. Beata Wojciak-Stothard lab Communications Biology 2022
nature.com/articles/s42003-022

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Hao Yin boosted
Francoise Helmbacher

Thank you @ondinecleaver2022 for the initiative

a few more:

@HaoYin @guijacquemet
@dgaboriau
@pj_saez
@rburdine
@juanonyme
@a_tsakiridis @maxvcg @harryleitch @AxelVisel @MHVerlhac @juliettemathieu @t_rayon @bbruneau @Etche_homo @albertcardona
@Amayran
@generegulation
@Sophie_Chauvet @kkroll @Mill_lab @MarieKmita

Everyone who wants to be known by the community should make a post with #DevBio or #DevBiol hashtags.
These will be seen across servers, making it easier to find each other

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Hao Yin boosted
Ondine Cleaver

35.5 mile bike today 🚴‍♀️🚴🚴‍♂️Not bad!

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Hao Yin

Antigen-presenting

PDGFRβ+ Pericyte MHCII KO->
In vitro
⏬CD4+ T cell proliferation & activation

In🐭adoptive transfer EAE
⏫CD3+ T cell entry
No change in BBB, CD4+ T cell, Mɸ, cytokine

Dr. Luisa Klotz lab @IJMS_MDPI 2022
mdpi.com/1422-0067/23/21/13081

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Hao Yin boosted
Francoise Helmbacher

#introduction Hi everyone, I am a developmental biologist, working at the IBDM (Developmental Biology Institute of Marseille) (CNRS and Aix Marseille University). I study muscle development and regeneration, trying to decipher the dysfunctional mechanisms underlying muscle pathologies. I would post with any new equivalent of the very useful #MyoTwitter

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Hao Yin

Landmark re-read😋

in the development of

"Cavernomas are composed of clones of Ccm3−/− cells that attract Ccm3+/+ cells"

Dr. Matteo Malinverno & Elisabetta Dejana lab Nature Comms 2019
nature.com/articles/s41467-019

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Hao Yin boosted
Ondine Cleaver

Let’s start a thread with all our: #DevBio #DevBiol #science peeps. Please add more below to help us find everybody! Who are your DevBio friends? We need to post to make this place more vibrant:
@DenisDuboule
@opourquie
@mads100tist
@RogersLabUCD
@HaoYin
@scottbarolo
@kkroll
@SpagnoliLab
@Mill_lab
@jamesbriscoe
@MokalledLab
@AaronJohnson
@ebardot

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Hao Yin boosted
Ondine Cleaver

Want Mastodon to become more interesting?
1. Connect with other #DevBio #DevBiol peeps here.
2. Post. It’s up to us to start talking.
3. Tell us about who we should follow (not all accounts visible on the follow lists of others, if on different servers).

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Hao Yin boosted
Mill_lab

@ondinecleaver2022 @DenisDuboule @opourquie @mads100tist @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot
Most excellent :ld: :lb: community wrangling Ondine! Little trick to filter is to make a #DevBio list- it is a little cumbersome as everyone and their instance needs to be individually searched and added, but then if you click on your list- posts only from those DB 'Mamoots' will appear. It can help focus from the other noise.

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