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JohnTaylor boosted

Joined the Mastodon train! Starting off with a post about my new skirt I just finished! Actually made the coat and top too :) excited to connect to other chemists and sewists on here!

JohnTaylor boosted

👋 👋 #introduction 👋 👋

#GlycoTime enthusiast based at the University of Basel in Switzerland 🇨🇭 🏔️ 🐮

We love ALL glycans, synthesizing native structures and mimetics thereof to study glycan interactions and develop new carbohydrate-based drugs 💊 ⚗️

JohnTaylor boosted

In positive news, happy to see my postdoc labmates Nick Shin and Elaine Tsui's work on SNAr on phenoxyls is up at JACS. Basically oxidize a phenol up to a phenoxyl and it SNArs like a juiced up nitroarene

pubs.acs.org/10.1021/jacs.2c10296

JohnTaylor boosted

#AcademicPeers #chemtoots #Chemiverse what a rush! We'll be moving our labs to University of Geneva next summer 🥳🤩🇨🇭

Wanna #join us? We are #hiring and have 1-2 #PhD positions in #organic and #supramolecular chemistry open NOW
🏁 at University of #Zurich then 🏃‍♀️🏃‍♀️ Faculty of Science | University of #Geneva

Interested working with us?
#this could be you ➡️ bit.ly/3DfGdVN
#discover us ➡️ rickhauslab.com
#apply ➡️ bit.ly/3SGWBod

JohnTaylor boosted

I know it's kind of cheesy, but it means a lot to me and is kind of surreal when you see an official protein database like InterPro updates its protein function citing your PhD's discovery. I still remember the feeling of seeing those CYRI-A's flashes surrounding those vesicles..

JohnTaylor boosted

Hi all, a little #introduction from me 🤗

I'm a new Lecturer (Assistant Professor) in Organic Chemistry and Chemical Biology at UCL Chemistry #London 🥳

My group develops methods to control nucleic acids (#DNA #RNA) and synthetic cells (#synbio) with stimuli, like light, temperature and magnetism - we use all sorts of chemistries like #photocages, #polymers, and #nanoparticles

I will also toot about parenting, #coeliac disease, and things I find funny!

#chemtoots #chemistry #chemiverse

JohnTaylor boosted

Greetings #Chemiverse!

My #Introduction:

Professionally, I am a scientist with backgrounds in nanomaterials, catalysis, electrochemistry & spectroelectrochemistry. Currently I am a postdoc for the Center of Sustainable Nanotechnology (CSN) & the Haynes lab.

I am passionate about: #chemistry #education, #mentorship, #advocacy, #scicomm, #ScienceHenna, #InvisibleWork, #travel, #poetry, #nature & #running.

Beyond that, I love to learn, explore, grow, & spend time with family & friends! 💙 🙏🏽

JohnTaylor boosted

Please contact me if you are interested in a 2-year postdoc fellowship at UCSD on AI in drug design, advancing our collaboration with Prof Rose Yu (Computer Science, UCSD)!

Application deadline is Dec 15, 2022.

postdoc.ucsd.edu/funding/schmi

JohnTaylor boosted

Time for an #introduction. I'm a critical care doctor in Edinburgh.

I lead a research programme using host genomics to identify modifiable molecular targets for drug treatment in sepsis/critical illness/respiratory viruses. We'll test therapeutic targets in lung using microdosing via AI-driven bronchoscopes.

I lead the #GenOMICC study, co-lead #ISARIC4C, run the Outbreak Data Analysis Platform, and co-direct the Pandemic Science Hub at Edinburgh University.

JohnTaylor boosted

An #introduction as I try to get the hang of this new space: I am a #supramolecular #chemist with interests in #flowchemistry , organic materials, macrocycles, and cages. I’m based at the University of Liverpool (all opinions my own etc).
I may talk about #automation in chem, #accessibility and #disability and #neurodivergence , our daft #cat or our exuberant kids, or I may just lurk while I get the hang of toots! Always interested in finding new #music too, tell me what you’re listening to.

JohnTaylor boosted

Nice paper from the Schapira lab identifying potential #ligand binding pockets for future #PROTAC development.

sciencedirect.com/science/arti

JohnTaylor boosted

Good morning! Time for another #science retrospective on Mastodon. In this paper we showed that (at least some) enzymes experience 'accelerated conformational searching' when they bind to their substrates. That is, they don't change the conformation space that they explore, but they explore it faster!

This is one of my favorite 'fundamental science' contributions from my group! Plus I got to do a TOC figure of a protein wearing sunglasses and riding a rocket.

onlinelibrary.wiley.com/doi/10

JohnTaylor boosted

Excited to present our BioRxiv preprint on chemical rational design strategies for developing molecular glue degraders through a covalent handle targeting RNF126! Congrats to Ethan Toriki and James Papatzimas and thanks to our Novartis collaborators! Also thanks to The Mark Foundation for Cancer Research! biorxiv.org/content/10.1101/20

Rational Chemical Design of Molecular Glue Degraders

Targeted protein degradation with molecular glue degraders has arisen as a powerful therapeutic modality for eliminating classically undruggable disease-causing proteins through proteasome-mediated degradation. However, we currently lack rational chemical design principles for converting protein-targeting ligands into molecular glue degraders. To overcome this challenge, we sought to identify a transposable chemical handle that would convert protein-targeting ligands into molecular degraders of their corresponding targets. Using the CDK4/6 inhibitor Ribociclib as a prototype, we identified a covalent handle that, when appended to the exit vector of Ribociclib, induced the proteasome-mediated degradation of CDK4 in cancer cells. Covalent chemoproteomic profiling of this CDK4 degrader revealed covalent interactions with cysteine 32 of the RING family E3 ubiquitin ligase RNF126. Structural modification of our initial covalent scaffold led to an improved CDK4 degrader with the development of a but-2-ene, 1,4-dione ( “ fumarate ” ) handle that showed improved interactions with RNF126. Thereafter, we worked to identify the minimum covalent motif required for interaction with RNF126, which we then transplanted onto chemically related and un-related protein-targeting ligands. This strategy successfully produced molecules which induced the degradation of several proteins across diverse protein classes, including BRD4, BCR-ABL and c-ABL, PDE5, AR and AR-V7, BTK, LRRK2, and SMARCA2. Our study undercovers a design strategy for converting protein-targeting ligands into covalent molecular glue degraders. ### Competing Interest Statement JAT, JMK, DD, MJH, MS, and LM are employees of Novartis Institutes for BioMedical Research. This study was funded by the Novartis Institutes for BioMedical Research and the Novartis-Berkeley Translational Chemical Biology Institute. DKN is a co-founder, shareholder, and scientific advisory board member for Frontier Medicines and Vicinitas Therapeutics. DKN is a member of the board of directors for Vicinitas Therapeutics. DKN is also on the scientific advisory board of The Mark Foundation for Cancer Research, Photys Therapeutics, and Apertor Pharmaceuticals, and is a consultant for MPM Capital and Droia Ventures.

www.biorxiv.org
JohnTaylor boosted

#introduction Hello #chemtoots and #sciencetoots I'm a photochemist, researcher and father of a 2year old. I find fluorescent molecules exciting and like sharing their beautiful colours and other science stuff. Still figuring out this new #chemiverse #chemisty

JohnTaylor boosted

#Introduction
I'm an #atmospheric chemist and mass spectrometrist at Bucknell University. My group (mainly undergraduates) studies #multiphase #chemistry of reactive gases at air-exposed surfaces, including inspiration from indoor building surfaces, the air-sea interface, #aerosol particle surfaces, lung fluid, and even insect surfaces! We use various mass spectrometry approaches to address #surface film chemistry questions.

#indoorchem #atmoschem #ChemiVerse #TeamMassSpec #airquality

JohnTaylor boosted

#introduction time!

I did my bachelor's and master's degrees in Chemistry (Sicily, Italy). Then I moved to Finland for a Ph.D. in Physics to sharpen my computational skills and knowledge #compchem.

In 2019 I moved to Heidelberg (Germany) to a biochemistry Lab for a postdoc at the Heidelberg University Biochemistry Center. I love #lipids, and I work on lipid-protein and protein-protein interactions using both computational and wet-lab experiments.

Currently struggling to become a PI :)

JohnTaylor boosted

I think I need more wine to write a proper introduction. But, I like proteins that stick to other proteins and create organised structures that bend phospholipid membranes. Why? They combine clever design with fundamental physical chemistry to maintain compartmentalisation of cellular functions. This means that I need to be a physical chemist and a bit of a cell biologist at the same time.

JohnTaylor boosted
JohnTaylor boosted

@freemo @zleap
Another app we may need to consider
is
curvenote.com

They integrate notebooks with text editor for version control and is an excellent editor. I will see if we can get the developers here and have a discussion. Great tool!

JohnTaylor boosted

It's #introduction time!

I recently completed my PhD in #chemistry in #photocatalysis and am very much still vibing with the #ChemiVerse especially as I'm still involved in plenty of #SciComm projects!

In September I joined the Royal Society of Chemistry as Development Editor for their Physical & Sustainability journals #publishing #ChemToots #ScienceMastodon

I am #genderfluid and use they/them pronouns 🏳️‍🌈

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