Joram Mooiweer @JoramMooiweer@qoto.org

Hello world! I’ve joined and am looking forward to what this new platform has to offer!

ICAM1-hi #EndothelialCell form Hotspots for #Neutrophil #TransEndothelialMigration (Paracellular)

Blunting ICAM1 heterogeneity
⏬TEM hotspots
⏫TEM-associated endothelial Permeability

Dr. Jaap van Buul lab @emboreports 2022 @joachimgoedhart @VanBuul_lab
https://www.embopress.org/doi/full/10.15252/embr.202255483

Impossible to make a better presentation on this great paper than first-author Max Grönloh @GronlohMax 👇

Also don't miss the informative Discussion session synthesizing the signaling networks of leukocyte TEM

Congratulations!👏👏👏

https://twitter.com/GronlohMax/status/1593299324192047110

A reminder of why we are trying to make a new and improved science community here on Mastodon.

Take a look at our recently published story about an unexpected role of B cells delaying intestinal mucosal healing!⏳🩹
A huge collaborative work with Annika Frede, Paulo Czarnewski, @ejvillablanca and many other! 🎉🎉🎉

https://www.cell.com/immunity/fulltext/S1074-7613(22)00592-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761322005921%3Fshowall%3Dtrue

Hi Mastodon! I'm a journalist at @sciencemagazine, where I delve into stories about the scientific community and the various challenges that come with pursuing a career in science. I'm a former scientist myself—I earned a Ph.D. in ecology and did a stint as a postdoc before realizing that the best career path for me lay elsewhere. Feel free to get in touch if you'd like to introduce yourself or suggest a story idea. #ScienceMastodon #academicchatter

Neutrophils are immune cells that do a lot of traveling (through the blood and into tissues) to get to sites of infection. Their large and stiff nuclei might it difficult for them to navigate through small spaces in tissues. So, how do they do it? Calì, Vargas, Viola, and colleagues showed that the signal that recruits neutrophils to target sites also makes their nuclei pliable so that they can squeeze through the gaps! Check out the study here: https://www.science.org/doi/10.1126/scisignal.abk2552 #science #immunology

Here's a terrific new paper from one of my classmates about #ImmuneCheckpointInhibitor induced #myocarditis. This work finds that CD8+ T-cells are the critical mediator of heart inflammation, and identifies the alpha-myosin cardiac protein as a candidate autoantigen: https://www.nature.com/articles/s41586-022-05432-3 #science #medicine #immunology #cardiology #oncology #Tcell #genomics #scRNAseq

Certified fresh study out from Yvonne Chen's group at UCLA, looking at how minute structural differences in CAR design can play an important effect on long-term CAR-T cell function: https://aacrjournals.org/cancerimmunolres/article-abstract/doi/10.1158/2326-6066.CIR-22-0504/711107/Rational-protein-design-yields-a-CD20-CAR-with

In one set of experiments, they look at how alanine addition to the extracellular part of the CAR, can twist the signaling domains, which apparently allows for better downstream signaling and effect.

Lots of cool stuff here, check it out.

#immunology #immunotherapy #CART #synbio

@cjayewong @cellcellpress @CellStemCell @cellpress @JoramMooiweer @CellGenomics @CellReports @cellhostmicrobe @scullingmonkey @CellMetabolism @TrendsCellBio
I’m editor for the journal Stem Cells, we had better get with the program!! #Stemcells

Hi #MedMastodon! 👋

#Introduction: I'm an #Endocrinologist at #Stanford, specializing in #Osteoporosis and #MetabolicBoneDisease. My lab studies #StemCells in bone 🦴 and the bone marrow microenvironment.

Some of my favorite topics: #WomenInMedicine #WomenInSTEM #PhysicianScientists #AAPI

@scullingmonke
@PLOSBiology
@medrxivpreprint
@biorxivpreprint
@nature
@WHO
@ThoraxJournal

An infection with one respiratory virus makes you less likely to become infected with another. This fascinating phenomenon, called "viral interference," may explain why we rarely see a perfect storm of viral epidemics, @joncohen writes.

https://www.science.org/content/article/competition-between-respiratory-viruses-may-hold-tripledemic-winter

(Bonus fact: This is where the name "interferon" came from.)

Alea jacta est re birdsite.
Let's figure out how to build a #CRISPR community here.

Finally set up a mastodon account thanks to @DavidBrueckner.

I love paper tweetorials (now mastorials?) and the pics of weird creatures (especially fish, insects, and deep sea creatures)!

Here's my account @MikiEbisuya.

About time for an #introduction. My research group at the Wellcome Centre for Human Genetics in Oxford uses #SingleCell techniques and Genome Architecture Mapping to study #epigenetics #Chromatin and #GenomeFolding in rare #NeurodevelopmentalDisorders.

I (He/Him) love to be outside #Hiking or #Cycling and I’m a big fan of #FlightFree travel. Interested in #Equity issues in STEM, trying to read and educate myself to be a better ally.

Toot at me with your #Andor theories!

Hi Mastodon, in my lab we use #stemcells and #organoids to find treatments for #mitochondria diseases.

I switched instances in the hope to have a more relevant local feed at mstdn.science.

So, let’s do this #introduction thing again.

I’m Pascal, father to 4 kids, #German #scientist and #carfree #cycling enthusiast. I live in #Utrecht, the cycling capital of the world and work as a #PostDoc at the #Hubrecht institute.

A couple of hashtags describing my work:
#Cancer #TheoreticalBiology #SystemsBiology #SystemsPharmacology #Signalling #Dynamics #Modelling #Organoids #DataAnalysis #Development

Hi Mastodon community, here’s my #introduction I’m a #gastroenterology researcher at #UCL growing #IBD #organoids to investigate #inflammasome regulation and #autophagy

Intro post: I'm a physician-scientist in #Gastroenterology at #UniversityOfMichigan. My training is in #Epidemiology, #virology, and #InflammatoryBowelDisease. I study the gut #microbiome and host #immunity. As a #queer person in #medicine, I advocate for #LGBTQ health and #inclusive research.

For your trouble, here's a photo of some mucin.