Julien Delpierre @JulienDelpierre@qoto.org

PhD position in Manchester, UK (BBSRC DTP): The evolution of nerves: understanding the roots of neurodegeneration – training in evolution biology, biochemistry, expansion or electron microscopy, cell culture, genetics, #scicomm – supervision: Prokop/Allan/Ronshaugen
Details: https://thenode.biologists.com/jobs/prokop

Hi #ScienceMastodon #Introduction here! I study cell fate determination and growth regulation in #Drosophila for my #PhD. Currently wrapping up at UMass Boston, and moving on to the #postdoc position soon at UMass Chan Medical School to explore new areas in epigenetics. Delighted to be here!

#AcademicMastodon #DevBio

It's probably time for an #introduction after lurking for a while.

I am a recent addition to the Nature Structural & Molecular Biology editorial team. I have very recently handed in my PhD - I used #cryoem and #cryoet to study #structuralbiology of viruses and vesicular trafficking.

Looking forward to engage with the #science community here!

Very cool study from the Garcia-Manyes Lab (TheCrick) exploring the previously dark side of the energy landscape of talin’s R3 domain using magnetic tweezers! Tapia-Rojo et al. observe new rare conformational states, beyond being binary, some of them capable of binding vinculin. These states may encode a new layer of mechanosensitivity in talin's R3 domain! #mechanobiology #biophysics

https://www.nature.com/articles/s41567-022-01808-4
https://www.nature.com/articles/s41567-022-01828-0

#introduction I'm a computer scientist, former professor now software engineer @ CZI. My interests are around image processing, software, and physical sciences. I am very into artificial life;" the study of life as it could have been."I was at formerly affiliated with Hampshire College, Brandeis University, Harvard Medical, HHMI Janelia Research Campus, UIdaho, DARPA, Max Delbrück Center, and Oak Ridge National Lab.

I've had some fun with tyssue (https://github.com/DamCB/tyssue). It is a 3D epithelium simulator, and I'm curious if folks other than @glyg on here are using it.

Hi! I am an Associate Professor and the head of the Laboratory of Cardiovascular Cell Biology at Vanderbilt School of Medicine (AKA The Burnette Lab). I also design clothing (mostly activewear) featuring photographs of cells taken through a microscope (Mag2Art.com).

Hello #ScienceMastodon ! I just made the Twitodon transition so a bit of #introduction: I'm a PhD Student interested in #DevelopmentalBiology, #Embryology and sometimes #StemCells and #Transcription. Looking forward to less promoted posts and more #AcademicToots.

Don't forget that Janelia's Computation & Theory area is looking for both [Senior] Group Leader candidates (https://www.janelia.org/our-research/our-labs/group-leaders) and Theory Fellows (https://www.janelia.org/our-research/overview/theory-fellows)! Are you working on interesting computational and theoretical approaches to address fundamental biological questions? Talk to us!

Rab8-, Rab11-, and Rab35-dependent mechanisms coordinating lumen and cilia formation during Left-Right Organizer development. https://www.biorxiv.org/content/10.1101/2022.10.31.514532v1 #Morpholino

I thought I would share this image, which I took a while ago, but that I really like! This is a #pituitary gland where cells expressing a protein called proopiomelanocortin (POMC for short) have been coloured in green. You can see two groups of cells; a very packed band in the middle and some sparse cells on the sides. The first are called melanotrophs, and they are important in determining skin and fur colour. The sparse cells on the sides are called corticotrophs (and that's what I am studying at the moment!) and they are important for the response to #stress . They secrete an #hormone called ACTH which stimulates the production of the stress hormone cortisol from the adrenal gland. At the moment we are trying to understand what happens to this cells after the body is exposed to stress for a prolonged amount of time. #scicomm #biology #science #physiology #microscopy

📢 📢 Exciting chance to come join us on a #rotation-based, 4 year, international #PhDStudentship- include our #TubulinCode project! Closing date: 9th January 2023. #imaging #cytoskeleton #cilia #ciliopathies #GenomeSurgery #RareDisease Message me, if you want to hear more! 📢 📢

More info: https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/four-yr-international-prog-human-genetics-genomic

We know that #centrosomes are not required for mitotic division, so what are they good for?

New preprint from the lab shows that having two duplicated centrosomes at the beginning of #mitosis facilitates rapid bipolar spindle formation. In the absence of centrosomes there is a checkpoint-mediated delay that is required to give enough time to sort things out and assemble the spindle.

#CellBiology
https://www.biorxiv.org/content/10.1101/2022.11.08.515699v1.full.pdf

Moving toward a better #resolution: our structured illumination microscope (SIM) allows to get 2 times better detail than classical widefield or #confocal #microscopy. Here's a #cellfie of a monkey cell labeled for the endoplasmic reticulum (yellow), clathrin (blue) and #actin (gray) 🔬

For a few months now I've considered doing a series of posts on women in #RNA #research (mostly PIs, maybe some #postdocs). My idea is to take the latest paper of their group and present it while highlighting previous key work. I already have a list of ~50 researchers (biased for those I know) - enough for a year of a weekly series.
Originally, I thought of doing it on the birdsite, but I just couldn't find time for it.
Moving here might be the kick I need to begin - hopefully this weekend.

As a #colourblind person, I appreciate people checking their figures in greyscale. But it's a lot of work to always convert your figures into greyscale, right? A lesson from digital artists: you don't have to!

There are easier ways for all operating systems! (see replies)

----

Checking your figures in greyscale may not resolve all visual impairment issues, but it really helps! Plus, it allows YOU to appreciate *contrast*. Use contrast to your advantage!