#LaminarShear pushes VE-PTP (How?🤓) to downstream pole of #EndothelialCell, followed by endocytosis->⏫p-Tie2
Potentially explain how #DisturbedFlow⏫#VascularPermeability & #Atherosclerosis
Inhibition of VE-PTP by AKB-9785 fortifies #EndothelialBarrier & reduces Atheromas at atheroprone regions (aortic arch inner curvature, arch+intercostal bifurcations)🐭
Nice comparison of anti-leakage strategies
VE-PTP inhibition
Angpt1 activation of Tie2
Angpt2 inhibition
Dr. Donald McDonald & Dietmar Vestweber labs EMBO Mol Med 2023
https://www.embopress.org/doi/
Hint:
"A sandbar is a shoal that develops in a stream as sediment is deposited as the current slows or is impeded by wave action at the confluence."
(Image: Wikimedia Commons, GNU-FDL 1.2, Doron)
Like a sandbar, except instead of gravity they collect via the electromagnetic force. Get it?
