Andrew Kennard @askennard@qoto.org

Expansion microscopy is one of the best things to come along in #cellbiology. A new preprint from Ons M’Saad in the Bewersdorf lab at Yale describes methods for ~8000-fold volumetric expansion and labeling that deals with the dilution problem associated with such huge expansion. Cell-level details can be observed with a cell phone camera!

https://www.biorxiv.org/content/10.1101/2022.11.29.518361v1

BEHOLD

I have survived another year despite the machinations of my haters, which can mean only one thing:

It's time to BATTLE SOME JAMS

Welcome to the Third Annual

"24 Days Until December 25th"

Ranking of the Entrants in the Bonne Maman Non-denominational Calendar of Jams!

#jamvent

actin a fool 🌞

#microscopy #science #biology #cellbiology #art

Not nearly enough #protists and #cilia in this universe yet... let's rectify this with an inaugural edition of #CiliaSaturday 😍
Look at all its beautiful 'feet'... !

Can't wait to be in Washington next week for #CellBio2022. Hit me up if you want to meet! (OK the song would be better for SfN, but it is good and I don't know any DC cell biology-themed band) https://youtu.be/HKGovH4Ge2M

Super excited to see my FIRST research paper published: https://elifesciences.org/articles/79647 🎉 about priority effects in nectar microbes 🌼🦠 . This epic story represents 10 years of work in our lab, much was led/facilitated by Stanford
undergrads and staff 🙏🏼. 🧵

Audio recording/papercast here 🎵 : https://on.soundcloud.com/PRpk5

Translated abstracts in Japanese, Mandarin, Spanish, German, and Hindi (see alt text): https://t.co/a2OHO4z4nS

James Kitchens' post on "Why Are There So Many Gene Trees?" Illustrating why genomes contain many different genealogical histories.
https://james-kitchens.com/blog/why-are-there-so-many-gene-trees

I thought this paper by Pacheco et al. was interesting, showing how mobile PI(4,5)P2 is on the plasma membrane. Surprisingly PIP2 is highly mobile even when engaged with e.g. clathrin machinery. Nice use of SPT/TrackMate and reporters to examine lipid distribution in the membrane.

https://rupress.org/jcb/article/222/2/e202204099/213711/PI-4-5-P2-diffuses-freely-in-the-plasma-membrane

Note: I'll try to boost interesting #cellbiology papers occasionally. Join me! Maybe we can use the #paperotd paper of the day hashtag of yesteryear.

If things had started out just a *little* differently, people might have actually learned the correct meaning of "chaos."

🚨JOB ALERT🚨
Our awesome team at Human Technopole in Milan, is hiring a Bioimage Analyst! You can find the job posting below. Applications close December 16th. Come and join us!

https://careers.humantechnopole.it/o/bioimage-analyst-and-research-software-engineer-computational-biology-research-center

I guess I should introduce myself #onhere: I am a postdoc in the Schier Lab at the Biozentrum (Switzerland). I am using #zebrafish to understand the #development of the nervous system. I love developmental biology of classic and non-canonical organisms, microscopy, loud music and comic books. Very much looking forward to meeting other scientists and cool people!
PS: I also help co-managing @ZebrafishRock , so make sure to give them a follow for the latest zebrafish community news

It's been years in the making (literally, my PR was ~ two years old 😅 ), but I finally updated Crispulator.jl to work with #julialang 1.0+.

It's ready to help you simulate your pooled #CRISPR screens for #functionalgenomics so that you can make sure they'll work before you pour many months into them!

Check out the refreshed docs: https://tamasnagy.com/Crispulator.jl/dev/

Almost that time of the year again. Who´s going to #CellBio2022?

I'm excited to share that our team has a new opening for a Computational Biologist role at Invitae.

We are a highly cross-functional research team of computational, experimental and clinical scientists with a mandate to maximize the utility of genomic information by developing and validating new insights into the effect of genetic variants.

https://boards.greenhouse.io/invitae/jobs/4710235

#hiring #genomics

Beautiful #cryoET paper on choanoflagellate #flagella #cilia revealing the enigmatic ciliary vane, new components and similarities to animal cilia
#protist #evolution #EM #choanoflagellate
https://elifesciences.org/articles/78133

is it surprising that nucleotide analogs are good cancer drugs, but not (to my knowledge) ribosomal poisons or anti-protein synthesis drugs?

The NIH Advisory Committee to the Director is starting a working group on “Re-envisioning NIH-supported Postdoctoral Training.” Slide deck here has some data and details: https://acd.od.nih.gov/documents/presentations/11032022_ACD_Working_Group_Postdoc.pdf

What would you like them to know? What would you like them to do?

#Introduction: I am curious about how proteins and membranes work in cells to deliver cargos. Multidisciplinary lab (with great collaborators) at UMass Chan Medical School #MembraneTraffic #Biochemistry #StructuralBiology #CryoEM #Biophysics #CellBiology #Genetics #Immunology
Also passionate to increase diversity, equity, inclusion and belonging in #Science #Academia.