Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Nothing less than complete enthusiasm will satisfy: you must at all times be thrilled to announce, excited to be part of, delighted to share. In this context, marking – which at most universities involves uploading long lists of numbers to creaking online portals that crash with abandon – is one of the few remaining repositories for an acceptable ennui, an apolitical ire. It unites the divided: everyone hates marking."
https://www.lrb.co.uk/the-paper/v45/n06/lorna-finlayson/diary
Hanuman inspired ceramics by @hunchbacksociety
#ceramics #handmade #ceramic #stoneware #handmade #ArtMastodon
"In this article, we share our experience of how we tried to overcome the difficulties of communicating fundamental science to the lay audience. Moreover, we give insights into the path we followed to create The Beautiful Brain, with the hope that our experience may be an inspiration to other basic scientists who wish to communicate their own research."
#Neuroscience #SciComm
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14604
In a recent commentary in Nature Reviews Molecular Cell Biology, @Odedrechavi & Pavel Tomancak present some ideas on how to credit the work of co-authors on publications - essentially how to figure who did what, now that it is not unheard to see papers with three or more joint first authors (and senior authors as well).
https://www.nature.com/articles/s41580-023-00587-x
The issue matters, of course, for research assessment and career progression. Bernd Pulverer and Thomas Lemberger discussed some alternatives beyond simple authorial credit, making use of emerging #OpenScience tools. You can listen to our conversation at the link below.
#EMBOPodcast
Thanks to @marcdionne for arranging an authentically grey & wet London experience.
It was a pleasure discussing the science behind the development of RNA vaccines with his students at Imperial.
'Recent studies have highlighted the value of using ancient genomes from different epochs, known as aDNA time series, to reconstruct the evolutionary history of immune disorders and past epidemics'
"We used a single-cell approach to retrieve the phenotype and TCR sequence of infected cells in blood and lymphoid tissue from individuals at the earliest stages of HIV infection. HIV initially targeted a few proliferating memory CD4+ T cells displaying high surface expression of CCR5."
Gantner et al @ImmunityCP
Great cover
"On the cover: A radial glial progenitor cell stands, sculpted out of cherry wood by Louis-Jan Pilaz."
The latest episode of the #EMBOPodcast is out, I discuss #OpenAccess, #OpenScience and the danger of amplifying existing inequities with Bernd Pulverer & Thomas Lemberger from @EMBOPress and Alicia Kowaltowski from the University of São Paulo.
🎧 👇
Squirrel! (look for it).
Visiting @hunchbacksociety to see some work in progress.
https://madalenaparreira.com/Hunchbacksociety
#ceramics #ceramicart #handmade #pottery #ArtMastodon #handmade #workinprogress
Interesting new paper from Orian Shirihai's group in @embojournal
"Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies"
https://www.embopress.org/doi/full/10.15252/embj.2022111699
Orian & I discussed his classic work on the mitochondrial life cycle (also published in EMBO J) on an episode of the #EMBOPodcast 🎧 👇
#mitochondria #mitophagy #metabolism
https://www.embo.org/podcasts/fuse-or-die-a-conversation-with-orian-shirihai/
'Here we leveraged an atlas of publicly available RNA-sequencing data of over 500,000 single cells from 15 individuals with AML and tissue from 9 healthy individuals for prediction of target antigens that are expressed on malignant cells but lacking on healthy cells, including T cells.'
'When I first saw the photograph, I didn’t recognize it as an Adams. Josie R. Johnson, a curatorial fellow at the Cantor Center for the Visual Arts at Stanford University, in Stanford, Calif., where I teach, planned to include it in an exhibition. She’d chosen the image for its otherworldly qualities. “It sticks with you,” she said, “for being such an enigma.”
https://www.nytimes.com/2023/03/13/travel/ansel-adams-photograph-sierra-nevada.html
My latest Clinical Pipeline column for #NatureMedicine is now online. A new take on heart failure using iPSC derived cardiomyocytes.
Another illustration by Madalena Parreira for the online content I created while at JEM - Dan Davis.
At the time, Davis had just published The Compatibility Gene - the lottery motif alludes to matching MHC types for transplantation. A common theme for this interview and the interview with Matt Cobb (https://flexnersuitcase.wordpress.com/2015/08/17/the-first-five-pages-a-conversation-with-matthew-cobb/) was how scientists find a publisher when they have a book project
https://flexnersuitcase.wordpress.com/2015/09/14/finding-stories-a-conversation-with-dan-davis/
'The evolution of the larva, though, altered brain development to make a modified, simpler brain appropriate for the sensory and motor demands of the larva. This larval brain, though, is not discarded at the end of larval growth and a new one made from scratch. Most larval neurons persist and some, like the interneurons mediating backwards locomotion, have similar functions in both larva and adult (Lee and Doe, 2021), but, as we show in this paper, the maintenance of neuronal function from larva to adult is not always the case.'
A conversation I had with @marcellaflamme from @PLOS about #preprints, #peerreview, AI, and, of course, #ReviewCommons has just been posted on the RC site.
"Q As we ask peer review to do more and more things, should we also be looking at new ways to recognize the work of reviewers?
LaFlamme: Another way to ask that question is: should outputs other than published articles and big grants count toward research assessment and the development of scientific careers?"
'We find the canonical Wnt pathway to be activated in mesenchymal progenitors (MPs) from cancer-induced cachectic mouse muscle. Next, we induce β-catenin transcriptional activity in murine MPs. As a result, we observe expansion of MPs in the absence of tissue damage, as well as rapid loss of muscle mass.'
https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00051-5
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
