Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Thus, identifying the subset of patients for whom public neoantigens are relevant targets is a major challenge. Nevertheless, the ability provided by the expansion of standard-of-care next-generation sequencing to screen patients affords the opportunity for off-the-shelf precision immunotherapies against public neoantigens that would be broadly applicable to many patients and would have tremendous advantages in scalability relative to targeting private neoantigens'
#Immunology #Immunotherapy #TumorImmunology
That's an impressive nosedive in fig 1 of this Nature Biotech piece (# of IPOs).
'To attract funding in 2023, biotechs need strong data (ideally clinical data), a differentiated asset or technology, disciplined spending, sensible time frames and realistic valuation expectations. Such basics were forgotten during the upturn, and inflated private valuations persisted beyond it — partly explaining the lower investment and merger and acquisition activity during 2022.'
'Our study reveals that probiotic Lactobacillus reuteri (Lr) translocates to, colonizes, and persists within melanoma, where via its released dietary tryptophan catabolite I3A, it locally promotes interferon-γ-producing CD8 T cells, thereby bolstering ICI.'
'Using single i-cell transplantation from transgenic fluorescent donors to wild-type recipients, we find that these cells are pluripotent. Under physiological conditions, a single i-cell can differentiate into all somatic cell types and into gametes. The presence of embryonic-like, pluripotent cells throughout adult life facilitates their ability to grow indefinitely in a plant-like fashion.'
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00404-9
'Now, Takahashi et al. showed that the inheritance of acquired methylation states is not restricted to highly repetitive transposable elements only but can also occur in promoter-associated CpG islands (CGIs) of endogenous genes.'
'Many art experts say Lichtenstein’s use of source comics was fair appropriation. Yet Eisman, 96, who lives in New Jersey, tells The Washington Post by email: “I’d say it’s theft.” He hopes people will watch the documentary and see it as evenhanded, intended to represent both sides with the aim to let “the viewers make up their own minds and not just leave it to the so-called experts.”
https://www.washingtonpost.com/comics/2023/04/05/roy-lichtenstein-documentary/
'In this Primer, we outline the current understanding of #chikungunya fever based on research in patients and animal models, which have provided considerable insights into the complex spectrum of disease manifestations and the mediators of arthritic immunopathology.'
#Immunology #virology
https://www.nature.com/articles/s41572-023-00429-2
"Understanding the mechanisms that maintain the endothelial barrier in the context of pathological stressors is the first step toward the development of new therapeutic approaches for retinopathies."
T2 Phage by Madalena Parreira, a drawing for a piece I did on the Hershey-Chase experiments when I was at J Exp Med (for the short-lived JEM blog).
"Thus, we performed a comprehensive screen of TE-chimeric transcripts across 10,357 tumors, 675 cancer cell lines and 11,686 Genotype-Tissue Expression (GTEx) adult tissues, and evaluated these TE-chimeric candidates for tumor specificity, antigenic potential, proteomic validation, HLA presentation and membrane presence."
#TumorImmunology #immunology
"These differences in expression necessarily limit the usefulness of these systems in identifying and understanding the more subtle roles played by ACE2 in the development and resolution of COVID-19. To overcome these limitations, we have developed two mouse lines in which the ACE2 locus has been humanized by syntenic replacement."
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011168
RIP Avrion Mitchison.
"Av initiated a series of experiments that collectively provided the conceptual framework of much of today’s understanding of immune rejection, tolerance and T–B cell co-operation."
'Here, we developed a memory-guided behavioral task that mice perform reliably in the head-fixed setting for months, and performed anatomical tracing, neural dynamic recordings, and optogenetic perturbations to characterize the role of these intervening circuits in memory consolidation.'
https://www.sciencedirect.com/science/article/pii/S0092867423001678?dgcid=coauthor
Some of my favorite cover illustrations by Madalena were not selected by editors - like this one for Ilana Gabanyi & @mucida's 2016 paper "Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages"
Strong opening:
"Like most forms of corruption, it began with men in suits."
"The multiple communication modalities characterized here reveal how nociceptors and DCs form a neuroimmune unit that integrates the nociceptors’ rapid responsiveness and finely honed ability to sense and respond to noxious stimuli with the DCs’ ability to coordinate innate and adaptive immune responses."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
