Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Here, we performed an extensive profiling of systemic myeloid cell populations and plasma soluble factors in NSCLC patients undergoing PD-L1/PD-1 blockade therapies, before and during treatment. Responder patients showed an elevated diversity of myeloid cell types, enriched in activated monocytic cells, and decreased granulocytic populations. Plasma FKN concentration correlated with myeloid cell diversity and response to PD-L1/PD-1 blockade."
Bocanegra et al @emboreports
#Immunology #immunotherapy
I love Current Biology - probably my favorite journal ever since I haunted the university library waiting for each new issue to read Sidney Brenner's Loose Ends. But maybe "Free Vaginas" is not the best layout option for their webpage.
Last two days to check out "Oubliette", a collective show by
@anaanajottajotta @consta_arouca @jorgenesbitt @madparreira at Biblioteca Camoes, Lisbon.
#Art #exhibition #artgallery
#sculpture #printmaking and more.
'Era una mujer sin nombre, de pie sobre una barricada en la Barcelona de 1936, una bandera rojinegra detrás. La imagen se imprimió en carteles y libros, se pintaron murales, y ella se convirtió en un icono de la Guerra Civil. Se desconocía su identidad. Y la del fotógrafo.'
They were here indeed .
A great week teaching MD PhD students of the multi-institutional EMERALD MD PhD program for the second year, this time at the Instituto Gulbenkian de Ciencia in Lisbon (last year at Centre for Genomic Regulation (CRG) Barcelona). Thanks to David Brena, PhD, Damjana Kastelic, Luis Moita, Gabriel G. Martins, Tiago Paixao & Ricardo Leite for making it all happen.
The first part was a one day workshop on modern scientific publication that David del Álamo and I designed. The rest was discussing the interplay of basic science and medical progress with a wonderful group of students.
... then it was the MHC, and then they came for CD38. Neuroscientists are pillaging the immune system for molecules again :)
Astrocyte CD38, neuronal circuit formation & social behavior in adults. Hattori et al @embojournal
Last few days to check out "Oubliette", a collective show by
@anaanajottajotta @consta_arouca @jorgenesbitt @madparreira at Biblioteca Camoes, Lisbon.
#Art #exhibition #artgallery
#sculpture #printmaking and more.
https://informacoeseservicos.lisboa.pt/contactos/diretorio-da-cidade/biblioteca-camoes
The current structure of science funding would make Max Perutz's work impossible and Perutz unemployed:
"Max, inspired by Bernal's vision that the structure of large and complex molecules such as proteins could be solved using X-ray diffraction, embarked on scaling a mountain in biology—solving the structure of haemoglobin. This was to take him more than 20 years."
https://www.embopress.org/doi/full/10.1093/embo-reports/kvf103
Keep your tacky Salazarist discovery monument - this is the Portuguese institution that matters.
'We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promoted peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis.'
#Immunology #MucosalImmunology #Neuroimmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00236-4
'Provision of Signal 2 from DCs to naïve T cells during priming is the second critical step [30], which usually takes the form of DC-expressed CD80 and CD86 interacting with CD28 on T cells. Consistent with this, Cd80−/−Cd86−/− mice have impaired CD8+ T cell responses after Ad5 immunization, but for reasons that remain to be elucidated Cd28−/− mice have a different phenotype: delayed but not fully impaired CD8+ T cell responses'
#Immunology #Vaccine
Last Thursday, the FDA voted to approve Sarepta's microdystrophin gene therapy for #Duchenne muscular #dystrophy.
https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy
This was not an easy call, made on the basis of a biomarker rather than efficacy data. I wrote about it last month for Nature Medicine.
If a slipper falls on a rooftop visible from an exhibition, is it art? #discussamongstyourselves
A great week at the soon to be extinct Gulbenkian Science Institute/IGC teaching MD PhD students of the EMERALD program.
Targeting FGF21 and GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.
#drugdiscovery #drugdevelopment #metabolism #LiverDisease #FattyLiver #SciComm
George and the FT might be hearing from The Onion's legal team soon.
https://www.ft.com/content/05808970-09a0-4f86-af23-4f05db627742
Targeting FGF21 & GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.
#drugdiscovery #drugdevelopment #metabolism #LiverDisease #fattyliver
There's more to gasdermin than just proptosis.
'Our study supports that differential cleavage of GSDMD can be understood as a regulatory hub controlling immunity versus tolerance in the small intestine.'
#Immunology #mucosalimmunology
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
