Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"For at least two centuries, scientists have been enthralled by the “zombie” behaviors induced by mind-controlling parasites. Despite this interest, the mechanistic bases of these uncanny processes have remained mostly a mystery."
'The analyses of RANK and RANKL expression in large cohorts of breast cancer samples and functional studies in RANK+ breast cancer patient-derived xenografts (PDXs) revealed a key role for RANK in postmenopausal women with estrogen receptor negative (ER-) breast cancer.'
Ciscar et al @EmboMolMed
https://www.embopress.org/doi/full/10.15252/emmm.202216715
Primer on the clinical uses of base editing tech @PLOSBiology
"In this Essay, we highlight base editing technologies and their development from bench to bedside. Base editing, first reported in 2016, is capable of installing C•G to T•A and A•T to G•C point mutations, while largely circumventing some of the pitfalls of traditional CRISPR/Cas9 gene editing."
#MolecularBiology #GeneTherapy
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002071
The von Willebrand Trust strikes again.
At the opening of "Oubliette" in Biblioteca Camões. Largo Calhariz 17 1º andar 1200-086 Lisboa. 16.06.2023 Até 30.06.2023. Exposição Coletiva.
Portrait of the artist making last minute adjustments. Congratulations to @madparreira @anaanajottajotta @jorgenesbitt @consta_arouca on a very successful opening. If you couldn't make it last night, 'Oubliette' will be at Biblioteca Camoes in Lisbon until June 30th.
#Art #artmastodon #artgallery
Back in (very sunny) Heidelberg! Looking forward to meeting students & postdocs at the Uni and reconnecting with my former colleagues at EMBO.
Who says we don't need another heron? by @hunchbacksociety #ceramics #stoneware #art #artgallery #handmade #artmastodon
It's official - we have a business! More news soon.
Celebrating with David del Álamo in Madrid.
My Clinical Pipeline column for Nature Medicine this week examines the state of Sarepta's new gene therapy for Duchenne muscular dystrophy application at the FDA. Whatever its final efficacy turns out to be, the general strategy behind the therapy, an engineered micro-dystrophin is very clever.
It was inspired by the case of a 61 year old patient who had a deletion of almost half of his dystrophin gene and was still alive and walking. Here's that ref, from 1990:
https://www.nature.com/articles/343180a0
And here's my column:
'Using an industry-standard test, he measured the particulate matter outside the mask, then checked how much made it through the device and into the space around his nose and mouth. Percentage-wise, he told me, “it removes 99.99 … I didn’t measure how many nines; it was working so well.” On broader scales, too, the protective math plays out: Well-fitting masks can curb smoke-related hospitalizations; studies back up their importance as a firefighting mainstay.'
https://www.theatlantic.com/health/archive/2023/06/mask-wildfire-smoke-n95-effective/674325/
‘In the winter of 1750, Jean-Jacques Rousseau threw away his watch. “Thank heavens,” he remembered exclaiming after this sublime gesture, “I shall no longer need to know what time its!”’
- Peter Gay, ‘The Enlightenment, the rise of modern paganism’.
#Books #BookClub #HistoryBooks #Philosophy #Bookshelf #bookstodon
"In this article – which builds on a preprint we posted in March 2022 (Corneille et al., 2022) – we describe a range of persuasive communication devices that can be used to exaggerate the importance of and/or hide the weaknesses of scientific work, and urge authors to exercise caution when thinking about using such devices"
Interesting addition to the toolbox, if you're working on #microglia:
"We generated a constitutive Cre line controlled by the microglia signature gene Crybb1 that produced nearly complete recombination in embryonic brain macrophages (microglia and border-associated macrophages [BAMs]) by the perinatal period, with limited recombination in peripheral myeloid cells."
https://www.cell.com/immunity/fulltext/S1074-7613(23)00040-7
Be there or be square (if you're Lisbon):
Exposição "Oubliette", inaugura 6ª feira dia 16 Junho às 18h30 na Biblioteca Camões em Lisboa. Pieces by Ana Jotta, Constança Arouca, Jorge Nesbitt & Madalena Parreira
Texts by H. Manfredsenjensen
Opening on Friday, June 16th at Biblioteca Camões, Lisbon (Largo Calhariz 17), 18h30.
"Françoise Gilot, an accomplished painter whose art was eclipsed by her long and stormy romantic relationship with a much older Pablo Picasso, and who alone among his many mistresses walked out on him, died on Tuesday at a hospital in Manhattan. She was 101."
(photo credit Robert Capa/International Center of Photography/Magnum Photos)
"Compared with other bacteria, #Salmonella, a facultative anaerobe, has higher motility and accumulation in tumors and a special advantage in targeting tumor quiescence, possibly via the chemoreceptors of Salmonella"
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00189-1
'Here, we summarize progress and challenges in the development of broad-spectrum antivirals that target either viral elements (proteins, genome structures, and lipid envelopes) or cellular proviral factors co-opted by multiple viruses via newly discovered compounds or repurposing of approved drugs.'
#Virology #Antiviral #drugdevelopment
"Presently, most nanobodies are produced by immunizing camelids; however, platforms for animal-free production are growing in popularity. Here, we describe the development of a fully synthetic nanobody library based on an engineered human VH3-23 variable gene and a multispecific antibody-like format designed for biparatopic target engagement."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
