Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary necrosis and autoimmune activation by intracellular self antigens. We show by multiple redundant and complementary methods that TBMs derive from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor that is prepositioned in the follicle.'
"The Origami Maps (Dresden, 1914-1918)
These maps, or objects, represent the sole known instance of an attempt at creativity by the Margrave. Like so many Europeans of his generation, von Willebrand was enthralled by Japanese art, and he developed a particular fascination with origami – a set of techniques with ancestral origins in Japan whose basic principles influenced the “folds of truth, folds of life and folds of beauty” ideas of German pedagogue Friedrich Fröbel.
Tragically, von Willebrand brought his newfound creativity to bear on the problems of cryptography – the Margrave was ever mindful of his duty to the Fatherland. von Willebrand’s work on the tactical applications of origami in the battlefield somehow managed to pique the interest of the Kaiser’s father, Frederick III, during his brief 99-day reign. When Frederick died, his relationship with the Margrave ultimately led his son Kaiser Wilhelm II to authorize a field test of the origami system during the Third Battle of Ypres. As a result, an entire German reconnaissance platoon was picked off one by one by a perplexed British sniper as they tried to fold paper while wearing full anti-gas gear." https://madalenaparreira.com/SPAM #maps #print #origami #origamiart #printmaking #handmade
Haruki Murakami on originality in art & literature (from "Novelist as a Vocation".
#books #writers #bookshelf #literature
'Apart from trans-acting protein factors, recent evidence points to a role of different RNA species in targeting repressive histone marks and DNA methylation to these sites in mammals. Here, we review recent discoveries on this topic and predominantly focus on the role of RNA methylation, piRNAs, and other localized satellite RNAs.'
"The neonatal Fc receptor and the planet Neptune share the distinction of having had their existence predicted by theoretical models before they were discovered."
My latest Clinical Pipeline column at Nature Medicine is out.
'Here, we show that in a mouse model of MS, T cell-specific Ahrknockout leads to recovery driven by a decrease in T cell fitness. At the mechanistic level, we demonstrate that the absence of AHR changes the gut microenvironment composition to generate metabolites that impact T cell viability, such as bile salts and short chain fatty acids.'
#Immunology #MucosalImmunology
Merchak et al @PLOSBiology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002000
This is accurate
"Italo Calvino was, word for word, the most charming writer to put pen to paper in the twentieth century."
https://www.newyorker.com/magazine/2023/03/06/the-worlds-of-italo-calvino
ICYMI, it was a pleasure to interview Nobel-prize winning immunologist Tasuku Honjo about the story behind his lab's discovery of PD1, a classic @embojournal paper from 1992.
🎧 #EMBOPodcast #EMBOJournal #Immunology #immunotherapy #checkpointinhibitors #HistoryOfScience
https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/
I don't think there is a way to convey online how cool these miniature etchings Madalena made are - they are almost postage stamp size in real life
"Here, we demonstrate the induction of both systemic and mucosal antibody responses against HuNoV in suckling mice using recombinant Rhesus rotaviruss expressing HuNoV VP1 or P domain."
#MucosalImmunology #Immunology #rotavirus
"Mechanistically, glycolysis augmented ATP production to boost STING activation and STING-dependent DC antitumor functions. Moreover, DC-intrinsic STING activation accelerated HIF-1a–mediated glycolysis and established a positive feedback loop."
Interesting piece in Nature about the type 1 #diabetes drug Teplizumab, the first that the FDA has ever approved to delay the onset of the disease:
I wrote about the drug in mid December for #NatureMedicine
"Here, we show that p53, one of the most commonly inactivated tumor suppressors in glioma, is a gatekeeper of astrocyte fate. In the context of stab-wound injury, p53 loss destabilized the identity of astrocytes, priming them to dedifferentiate in later life."
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00152-5
Great cover for the current issue of @CellMetabolism
Had a great time yesterday opening the Algarve University Hospital Center's (CHUA) conference, speaking on the research origins of some of today's key drugs & the limits of translation.
And Rous' hen, of course :)
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
