Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Gullotta et al. explore ischemic stroke in aged mice and elderly people, identifying age-related alterations in stroke-induced granulopoiesis and characterizing a pathogenic signature of circulating neutrophils that is linked to poorer outcomes. Reversing the neutrophil phenotype in old mice by transfer of young hematopoietic cells improved tissue repair and regeneration after stroke'
Works in progress @hunchbacksociety
#ceramics #stoneware #artgallery #handmade #ceramic #artmastodon
Now that I've read the credits, I want to go back and pay more attention to Mr Lawrence's performance.
“The carrion birds sat about the topmost corners of the houses with their wings outstretched in attitudes of exhortation like dark little bishops.”
#CormacMcCarthy #BloodMeridian #Books #Bookshelf #ClassicBooks #bookstodon
'Comparison of Xenopus species that evolved through polyploidization revealed that metabolic differences emerged during development when cell size scaled with genome size. Thus, ploidy affects metabolism by altering the cell surface area to volume ratio in a multicellular organism.'
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00391-3
In which @madparreira made a fully wearable dress out of paper - and then printed it!
Another entry in our 'not all good wines are Portuguese' series, courtesy of my gracious host in Nice, @miguelgf
"To enable detection of which cells upregulate MHC pathways in vivo, we generated two novel MHC I and MHC II reporter mouse lines that express tdTomato when these pathways are activated, and used these lines to define their incidence and transcriptional characteristics in two mouse models of inflammatory demyelination."
#Neuroimmunology
'I said, “I’m not really sure I want to do a cop show.” And Levinson said: “This is about the homicide detectives. They’re thinking cops. There’s no gun battles, there’s no car chases.” And I said: “That’s impossible. I’ll do it.”
Obesity and #covid19 vaccination.
"Here we focus on individuals with severe obesity (those at highest risk). We conducted a prospective, longitudinal study that allowed us to demonstrate that, although initial and peak responses were similar in individuals with severe obesity and individuals with normal weight, there was accelerated decline in antibody levels over time that correlated with increased frequency of hospitalization and mortality from breakthrough infections."
'They observed the significant induction of IFNβ and other inducible chemokines in the medium of primary microglia treated with tau fibrils, which was abrogated by the genetic ablation of Cgas. This raised a question: how does tau protein activate this DNA sensor? Through a series of clever in vitro experiments, the authors demonstrated that tau fibrils localize to microglial lysosomes and mitochondria and that they promote the release of mitochondrial DNA (mtDNA) to the cytosol'
CART cells beyond cancer - my latest Clinical Pipeline column for Nature Medicine is out. CAR T cell technology in humans was first tried for HIV in the 90s. Now veteran HIV researchers are giving them another shot.
#immunotherapy #publichealth #hiv #Immunology #cartcells
#ScienceCommunication #SciComm #InfectiousDisease
Potentially good news that the EU is considering to move beyond #OpenAccess mandates and do away with author publication fees - and fund scientific publication directly.
To me, one problem in the way we talk about this is the tendency to discuss "journals" as a monolithic entity. On a previous episode of the #EMBOPodcast Adriano Aguzzi, Thomas Lemberger & I discussed if funding agencies should establish stricter parameters for which journals could be funded. The community can rate what matters - this is the sort of thing that could give DORA principles some teeth for example. Quality peer review, track record of publishing reliable work, inclusivity, tools for data analysis, etc.
If you want to jump to this bit in the episode ("From Prions to Preprints"), go to minute 19.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
