Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Arthur Bispo do Rosario, a former Marine Corps signalman, boxer, tram cleaner and domestic worker in Rio de Janeiro, had no interest in defining his extensive activities as art. His unusual embroidered garments and textiles, ingenious assemblages and use of language had a higher purpose: Bispo was Jesus Christ, according to angels who visited him the night of Dec. 22, 1938, and instructed him to record, or possibly replicate reality. Thus, the title of his first retrospective in the United States, at the Americas Society in Manhattan: “Bispo do Rosario: All Existing Materials on Earth.”
https://www.nytimes.com/2023/05/05/arts/design/bispo-do-rosario-brazilian-artist.html
The East River, by @madparreira
#Print #Printmaking #handmade #printmakingart #artgallery #artmastodon
"It is conceivable that, although extensive genetic and epigenetic evolution occurs within cancer models, such evolution might not translate into biologically meaningful cellular properties. That is, this phenomenon could represent a molecular curiosity with little practical implication. Unfortunately, this does not seem to be the case. Genomic changes that arise throughout model propagation have been associated with marked phenotypic changes across all cancer model types"
John le Carré did not appreciate Clive James' reviews. (from "A Private Spy. The letters of John le Carré", edited by Tim Cornwell). #Books #Bookshelf #Reader #JohnLeCarre #Bookclub #literarycriticism #bookstodon
'In this Essay, we discuss recent findings related to changes in the metabolic functions of immune cells (immunometabolism), particularly mitochondrial dysfunction, in innate and adaptive immune cells and their contribution to the generation of autoimmunity, with emphasis on systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002084
@mucida The paper also has a very interesting evolutionary scenario
"Unbiased phylogenetic analyses indicated that this family and its receptors28 share greater sequence/structure homology to IFN and IFN-receptors than other cytokines/cytokine-receptors (Figures S1A and S1B; Table S3). Notably, the heterodimeric receptor subunits of the IFN and IL-10 families also sub-clustered, suggestive of a common ancestral heterodimeric receptor specific to these two families (Figure S1B). In contrast to IFNs, however, the IL-10 cytokine family has not been as clearly linked to pathogens/danger signals. This raises the tantalizing possibility that, during evolution, these pathways may have bifurcated from a common ancestor to cope with the increasing diversity of pathogens and injuries."
'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al
I wrote about RSV vaccines in my #NatureMedicine column in February.
Very good news this week with the FDA approval of GSK's RSV vaccine for adults 60 and over - it's the first approved RSV vaccine.
https://edition.cnn.com/2023/05/03/health/first-rsv-vaccine-approved/index.html
Several other candidate RSV vaccines are at a late stage of development, including mRNA based vaccines. The next big thing to watch for are those seeking to protect newborns and infants by maternal immunisation.
#RSV #Vaccine #RespiratoryVirus #drugdevelopment #Pharma #Immunology
From Oliver Sacks, "River of Consciousness".
#Books #Bookshelf #BookClub #consciousness #SciComm #readerlife #bookstodon
What a great cover.
From the NYT obit for artist Bruce McCall
'GSDM (the gene encoding gasdermin) and GSDM-like genes are evolutionarily ancient and have been identified across a wide range of animal and nonanimal species, including fungi and bacteria.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002103
'These distinct roles for EZH2 in promoting prostate cancer progression, metastasis, and AR independence raise the possibility that it could be a potential therapeutic target in advanced disease.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002038
'Writing in Nature, Krishna et al.2 show that malignant gliomas can grow by modifying brain circuitry, thus taking cognitive function away from their host and ultimately leading to death. These insights might lead to fundamentally new approaches to glioma treatment and provide a means of limiting cognitive decline in affected individuals.'
'C closed his eyes briefly. “Have you any idea how fucking rhetorical that was?”
This time, Howard didn’t reply.'
'Marsella, capital de la Provenza, es una ciudad de ciudades, la más antigua y la más diversa de Francia. Una muñeca rusa que entraña tantas posibilidades como ambición tenga cada visitante.'
'Our findings demonstrate that developmental bias in fly wings predicts evolvability and macroevolutionary trajectories on a much greater scale than previously appreciated but also suggest that causal explanations for such alignments may go beyond simple constraint hypotheses.'
#Evolution #EvoDevo
Etching on copper by @madparreira
#printmaking #art #print #printmaker #etching #handmade #prints #artgallery #artmastodon
https://madalenaparreira.com/Etchings
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
