Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
@evilmicrowizard Yes, the FT has a pretty solid wall. Here's a related piece in The Guardian, from a couple of years ago
"What made the casket unusual was not the length of its journey but what was inside: a single, gold-capped molar. It belonged to Patrice Lumumba, the anti-colonial hero, pan-African nationalist and the DRC’s first democratically elected prime minister, who was tortured and assassinated in 1961."
https://www.ft.com/content/eca1ba35-aa02-4c5c-b5fa-d93f36ed7c0d
Thiago Carvalho
boosted
Extrachromosomal #Borg elements in methane-consuming #archaea are scattered with rapidly evolving nucleotide #TandemRepeats; those within genes encode amino acid repeats that create intrinsically disordered regions @MScholmerich @BanfieldLab #PLOSBiology https://plos.io/3Y0cw3R
Thiago Carvalho
boosted
Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma
Thiago Carvalho
boosted
Virology under the Microscope—a Call for Rational Discourse
@JVirology https://journals.asm.org/doi/10.1128/jvi.00089-23
Thiago Carvalho
boosted
Science & its discoveries are no use without communicating them.
#podcasts are just another way to achieve this in an accessible form to both scientists and the general public.
Should be embraced whilst ensuring they contain healthy level of critique and checking for total misinformation!
#Science #academia #scicomm #communication @sciencemagazine #research
US may phase out the first generation of Covid19 vaccines:
"An expert committee advising the Food and Drug Administration recommended on Thursday that regulators phase out the original versions of the Covid-19 vaccines, allowing Americans getting their first shots to receive the updated formulations now used as boosters."
#COVID #COVID19 #vaccine #PublicHealth
https://www.nytimes.com/2023/01/26/health/covid-vaccines-boosters.html
Thiago Carvalho
boosted
We're all mad here.
191 years of #LewisCarroll.
#author #birthday #otd #book #bookstodon #illustration #drawing #alice #aliceinwonderland #throughthelookingglass
Thiago Carvalho
boosted
This is the future - or rather a big part of the future - of structural biology - in situ structural biology. Great work.
RT @MaxGemmer@twitter.com
Very happy to share our recent work on protein biogenesis at the ER membrane. We analyzed 150,000 ribosomes from 1000+ tomograms of ER-derived vesicles to visualize ribosome intermediates and their downstream translocon machinery.
1/
#TeamTomo #CryoEM
https://www.nature.com/articles/s41586-022-05638-5
🐦🔗: https://twitter.com/MaxGemmer/status/1618495422988947457
"Enter the nocturnal Pentalagus furnessi, or Amami rabbit, the world’s only dark-furred wild bunny. In a study published this week in the journal Ecology, Dr. Suetsugu and Hiromu Hashiwaki, a co-author also of Kobe University, posit an evolutionary bargain between Amami rabbits and B. yuwanensis. The root-sucking plants give food in exchange for seed dispersal services — something that has never been documented between a mammal and a parasitic plant."
https://www.nytimes.com/2023/01/26/science/rabbit-parasite-plant-islands.html
Thiago Carvalho
boosted
RT @ScienceMagazine@twitter.com
The Amazon rainforest is one of the most vital major ecosystems on Earth—but it is under threat.
In this issue of Science, researchers underscore the rapid and profound changes occurring in the Amazon resulting from ever-increasing human activity. https://scim.ag/1iX
🐦🔗: https://twitter.com/ScienceMagazine/status/1618686477612769280
From Michael Bishop's 1982 Lasker acceptance speech:
'On an early morning in 1925, Robin Fahraeus became the first person to witness a biological molecule sediment in a gravitational field. You might find this an abstruse event, but Fahraeus felt otherwise. He roused his colleague, The Svedberg, from sleep with a phone call and a memorable message: “The, I have seen a dawn.”'
https://laskerfoundation.org/winners/1983-albert-lasker-basic-medical-research-award/#_
Thiago Carvalho
boosted
Large language models generate functional protein sequences across diverse families.
Super interesting #ProteinDesign work.
#StructuralBiology #Crystallography
@strucbio
https://www.nature.com/articles/s41587-022-01618-2
Thiago Carvalho
boosted
RT @jandraRV
A postdoc position is now open in my lab! If you want to work on an NSF-funded project and are fascinated by eco-evolutionary dynamics, synthetic communities, and experimental evolution, please apply by Feb 15 https://recruit.ap.uci.edu/JPF08060
Please RT!
Thiago Carvalho
boosted
The demise of an electronics giant: the men who killed General Electric https://physicsworld.com/a/the-demise-of-an-electronics-giant-the-men-who-killed-general-electric/
@hasmis @gpollara @eLife @ImmunityCP
In a most delightful way
@gpollara An interesting aspect of this was discussed by the senior author of this @eLife paper, Russell Vance, who co-authored a perspective piece in @ImmunityCP in 2014 about "The Macrophage Paradox", essentially why do so many pathogens find it so cozy inside the cell type that's supposed to eat them.
Thiago Carvalho
boosted
@cyrilpedia And the flip side to this shows how many layers of host defences need to be overcome by pathogens that succeed in surviving in the intracellular environment. Looking at you.... #TB #tuberculosis! 😉
"Our findings underscore the importance of cell death in defense against intracellular bacterial pathogens and provide an example of how layered and hierarchical immune pathways can provide robust defense against pathogens that have evolved a broad arsenal of virulence factors."
#Shigella #HostPathogen #CellDeath #Apoptosis #InnateImmunity #Pathogen #Microbiology #Immunology
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
