Thiago Carvalho @cyrilpedia@qoto.org

"Here, we investigate a β-cyclodextrin nanoparticle (CDNP) formulation encapsulating the Toll-like receptor 7 and 8 (TLR7/8) agonist R848 (CDNP-R848) to reprogram myeloid cells in the glioma microenvironment."

#immunology #TollLikeReceptor #InnateImmunity #Immunotherapy

https://www.nature.com/articles/s41467-023-36321-6

'Virulence of C. difficile also has an intimate relationship with nutrient availability as, upon nutrient limitation in the gut environment, C. difficile responds by producing toxins that liberate host-derived nutrients through cytotoxic activity and creation of a proinflammatory environment'

#Clostridium #InfetionImmunity "Metabolism #Microbiology

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011034

The fly
#Ceramics

https://madalenaparreira.com/Hunchbacksociety

"Julien Keller’ was the nom de guerre of Adolfo Kaminsky, who died in Paris last month aged 97. It was largely thanks to him that the German-occupied zone of wartime France was flooded with false documents. The Occupation authorities were on his trail, but they never suspected that the forger they were after was a teenager."

https://www.lrb.co.uk/the-paper/v45/n04/adam-shatz/beyond-borders

I wrote this with Akiko Iwasaki, & Florian Krammer this at the end of 2020 for Nature Reviews Immunology. It's still an important point today: we need to learn from this pandemic, there will be others.

"There are many lessons to be learned from this pandemic, which will hopefully prepare us better for future pandemics. SARS-CoV-2 will likely not be the last coronavirus to cause a pandemic and it is likely that coronaviruses that are now endemic in humans first caused pandemics resulting in large numbers of deaths"

https://www.nature.com/articles/s41577-021-00522-1

"Here, we investigated the fetal hematopoietic response to maternal infection with Toxoplasma gondii (T. gondii), an intracellular parasite that elicits Type II IFNγ-mediated maternal immunity."

#immunology #Parasitology #Toxoplasma #HostPathogen #InfetionImmunity #Preprint

https://www.biorxiv.org/content/10.1101/2022.11.29.518417v3

Antimicrobial resistance seminar in the wild with @marcdionne

'Surprisingly, carbon accounting is still not widely established in academic institutions. EU regulations require larger companies to publish regular reports on the social and environmental impacts of their activities (https://finance.ec.europa.eu/capital-markets-union-and-financial-markets/company-reporting-and-auditing/company-reporting/corporate-sustainability-reporting_en#standards), but there are no similar requirements or standards for universities or publicly funded research institutions.'
Winter et al @emboreports

https://www.embopress.org/doi/full/10.15252/embr.202256683

@zleap thanks for catching that

If this were the Turing Test, AI would have full citizenship by now

'Think back to the last research article you read. (If you can’t remember reading one recently, maybe you blocked out the experience.) Had that article been written by artificial intelligence (AI)—which, in this context, refers to an algorithm, not a colleague who feigns aptitude—would you have known?'

https://www.science.org/content/article/scientists-don-t-let-your-writing-resemble-something-you-pulled-out-your-bot

“We’re collaborating on the question of why bats are such a fantastic vector,” said Rynda-Apple. “We’re trying to understand what is it about their immune systems that makes them retain the virus, and what is the situation in which they shed the virus.”

https://www.scientificamerican.com/article/a-secret-weapon-in-preventing-the-next-pandemic-fruit-bats/?utm_source=newsletter&utm_medium=email&utm_campaign=week-in-science&utm_content=link&utm_term=2023-02-10_top-stories&spMailingID=72653219&spUserID=MTEyNzc3Mzc0NDY4S0&spJobID=2300912238&spReportId=MjMwMDkxMjIzOAS2

I hope they made it into the acknowledgments

'Over the years, the film has acquired a kind of notoriety, too, because Beals did so little of Alex’s dancing. Most was performed by a French dancer, Marine Jahan. And in the climactic audition scene, there were more doubles: the gymnast Sharon Shapiro for the dive into the roll; and for the backspin, the 16-year-old B-boy Richard Colon, better known as Crazy Legs.'

https://www.nytimes.com/2023/02/09/arts/dance/flashdance-40th-anniversary.html