"...reveals a previously unrealized pro-apoptotic function of the peptides generated by a variety of proteolysis-modulating compounds."
Constitutive protein degradation induces acute cell death via proteolysis products https://www.biorxiv.org/content/10.1101/2023.02.06.527237v1
RT @biorxivpreprint
Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism https://biorxiv.org/cgi/content/short/2023.02.10.527741v1 #bioRxiv
Call for Nominations for SMBE’s prestigious Faculty Awards!
This is the time for our members to send us your recommendation of your favourite colleague for Early- or Mid-Career, Lifetime Achievement or special service to the EcoEvo community.
Postdoctoral Scientist In Epigenetics & Neuroscience
#ScienceJobs #job
Dallas #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/ut-southwestern-medical-center-27778-postdoctoral-scientist-in-epigenetics-neuroscience-2/?feed_id=37735
EMBL-UNESCO Residency in #Infection Biology Research
'The successful candidate(s) will be hosted by one or more group leaders within the Infection Biology Transversal Theme, spread across EMBL’s six sites in Europe – who will mentor and co-develop the project proposed by the candidate, in line with the group’s research focus.'
https://www.embl.org/about/info/scientific-visitor-programme/fellowships/embl-unesco-fellowships/
"When Twitter announced on 2 February that the social media platform would end free access to its application programming interface (API) in a week, meaning tomorrow, a clock began ticking for Jean-Philippe Cointet. Like other researchers interested in topics such as political polarization or how misinformation spreads, the social scientist at Sciences Po uses the API to freely gather data on the hundreds of millions of tweets sent daily."
RT @mw_umn_labs
Excited to share our collaborative work with the @IngunnStromnes lab, out today in @NatureComms. Genome engineering and immunology join forces to create a powerful new model to study T cell development and function.
https://www.nature.com/articles/s41467-023-36180-1#disqus_thread
High quality research needs a supportive research environment. Our new paper in Nature Human Behaviour discusses how currently national academic systems fail to facilitate robust science.
Read it here: http://rdcu.be/c5brE
The role of Evi/Wntless in exporting Wnt proteins
In their #OpenAccess Review, Lucie Wolf and Michael_Boutros summarise the mechanisms of Wnt ligand export and recent structural insights, with a focus on the Wnt transport protein Evi/Wntless.
There’s no doubt that the UK has been a massive net beneficiary of the Horizon Europe programme for research funding.
Oxford and Cambridge alone used to receive an annual £130m of EU funding but are now down to £1m between them.
Brash declarations to ”go it alone” or form a coalition with the US, Switzerland and Japan show stunning disregard of how science works.
Now open for registration:
Cold Spring Harbor Asia:
Systems Biology of Gene Regulation and Genome Editing
Suzhou, China
October 23 - October 27, 2023
'Back in Aix, his discussion circle had included not only Émile Zola, on a fast track to celebrity, but a formidable young scientist called Antoine-Fortuné Marion. It was Marion who alerted the group to the recent revolutions in thought advanced by Lyell and Darwin. Zola articulated their response in 1865: ‘I see in the study of geology a new faith, a faith both philosophical and religious.’'
https://www.lrb.co.uk/the-paper/v45/n04/julian-bell/mass-equals-pigment
Study finds "a recent diagnosis of OSA requiring treatment was associated with an increased hazard of testing positive for COVID-19 and serious COVID-19-related complications, particularly in those with co-existing chronic airways disease."https://thorax.bmj.com/content/early/2023/01/30/thorax-2022-219574
“Las estrategias climáticas de la mayoría de las empresas están atascadas en compromisos ambiguos, planes de compensación que carecen de credibilidad” y programas que no contemplan todas las emisiones que genera cada multinacional'
Best #ValentinesDay marketing email award this year has to go to @rayyanapp ... 👇
#academia #systematicreview #collaboration
'Quem ler o texto fica com a sensação de que a extrema-direita nos caiu em cima por geração espontânea, obra e graça dos ventos da história, sem responsabilidades que possam ser assacadas. Não há referência ao desastre da liberalização dos mercados que marcou a governação dos partidos “da área política” de Augusto Santos Silva'
https://www.publico.pt/2023/02/13/opiniao/opiniao/farmacia-augusto-santos-silva-2038595
And another thread for #histodons enjoying #paperhistory. Today, we focus on #cartography as a paper art.
You see the famous painting of late seventeenth-century from the Dutch Johannes #Vermeer that reflects some of the paper usages of early modern cartography: "De geograaf" was a paper using man; early modern #cartography was a paper world of its own.
By the way, the #Rijksmuseum in #Amsterdam just opened an exhibition on Vermeer these days: https://www.rijksmuseum.nl/en/johannes-vermeer?ss=
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Opportunities in protein biogenesis and quality control at UChicago @keenan_lab
We are #hiring–come join us @keenan_lab!
#ScienceJobs #job #Scientist #Postdoc #cellbiology #biochemistry #structuralbiology #cryoEM
Chicago ...
https://jobrxiv.org/job/university-of-chicago-27778-opportunities-in-protein-biogenesis-and-quality-control-at-uchicago/?feed_id=37719
"Our results showed that the Omicron lineage had an accelerated mutation rate in the RBD region, while the mutation incidence in other genomic regions did not change dramatically over time."
Interesting piece on companies bringing bringing #microbiome analysis into the clinic for their predictive value in cancer #immunotherapy. But take it with this major boulder of salt:
“I think that it’s certainly worth doing,” says Steven Salzberg, computational biologist at Johns Hopkins. “But you have to be really skeptical of what you find.” Before they become widely adopted, the field needs validation, replication and large gold standard trials.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com