Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Excess mortality among non #COVID19 surgical patients in 🇫🇷 French intensive & intermediate care units during #pandemic, nationwide study demonstrating considerable increase in surgical death risk during periods of high hospital exposure to #SARSCoV2 cases in ICU/IMCU beds. The majority of excess in‐hospital mortality resulted from inpatient deaths outside of #ICU/IMCU, suggesting limited access to critical care following surgery.
Free to read #FOAMcc on @ICM
https://rdcu.be/c6oHy
Thiago Carvalho
boosted
Postdoc for studying proteostasis, aging, biological clock and metabolism @LabZhu
Postdoc position for studying 12h clock regulation of phase separation dynamics, proteostasis, liver metabolism and aging at University of Pittsburgh
Thiago Carvalho
boosted
New preprint, by Victor Rossier with the group of Christophe Dessimoz (#UNIL and #SIB), introducing #Matreex, a new dynamic tool to scale-up the visualisation of gene families, and its application to showing loss of intraflagellar transport in a myxozoan
https://www.biorxiv.org/content/10.1101/2023.02.18.529053v1
#phylogeny #phylogenomics #bioinformatics #BigData #visualization #vizbi #myxozoan @dee_unil
1/thread
Thiago Carvalho
boosted
Thiago Carvalho
boosted
RT @Marc_Veld
Some #Immunology101:
A virus infection induces a strong T cell response. In the case of a virus; a type-1 response: involving Th1 cells and CD8 T cells. These cells are known to make the cytokine interferon-gamma (IFNg). They express activation markers, including PD-1.
'The N.I.H. said its scientists, some of whom had been collaborating for years with Moderna, had helped to design that sequence. Moderna also received nearly $10 billion in taxpayer funding to develop and test the vaccine, and to provide doses to the federal government. The company has sold roughly $36 billion worth of coronavirus vaccines worldwide.'
'How does amphibian MHC diversity fit in the landscape of vertebrate evolution? Minias et al. (2022) address this gap in the field of MHC evolution by focusing on the lesser described MHC class I in salamanders'
https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad033/7051149?searchresult=1
Still the best parenting video ever made
'Derrotado frente a su hijo, el coronel Márquez volvió a la vida civil y vivió más de tres décadas como veterano de guerra, hasta que murió en 1937. García Márquez vivió con él, sus padres lo dejaron a su cuidado desde que era un bebé, y siempre contaba que uno de sus primeros recuerdos de infancia era dormir en un colchón junto a la cama del coronel.'
Regulatory CARTs #preprint
"The InsB-g7 CAR re-directed NOD Treg specificity such that insulin B 10-23-peptide stimulation enhanced suppressive function, measured via reduction of proliferation and IL-2 production by BDC2.5 T cells and CD80 and CD86 expression on dendritic cells. Co-transfer of InsB-g7 CAR Tregs prevented adoptive transfer diabetes by BDC2.5 T cells in immunodeficient NOD mice"
A reasonable proposition:
"Given the growth of withdrawals due to negative confirmatory trials and emerging evidence on the high spending associated with AA drugs, it is critical to balance early access against population-level exposure to cancer therapies with no benefit over standard of care."
In Aicardi-Goutières syndrome patient samples
"Using machine-learning approaches and differential gene expression we identified a drastic loss of transcription factor hypoxia induced factor 1 alpha (HIF-1a) expression and activity associated with features of a metabolic switch and mitochondrial stress in monocytes/dendritic cells."
Fits well with earlier work from Jocelyne's lab:
"Type I IFN sets the stringency of B cell repertoire selection in the bone marrow" (1999)
https://academic.oup.com/intimm/article/11/2/279/759572
and
"Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice" (2003)
https://www.sciencedirect.com/science/article/abs/pii/S0896841102001099
'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'
#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity
Thiago Carvalho
boosted
89. Moon Pine in Ueno, 1857 #hiroshige #utagawahiroshige https://www.wikiart.org/en/hiroshige/89-moon-pine-in-ueno-1857
"One of my current projects, called CryoEM-101 (http://cryoem101.org), is an online, media-rich course that provides practical guidance to those looking to learn about electron cryo-microscopy and tomography."
https://www.cell.com/current-biology/fulltext/S0960-9822(22)01958-3
"Here, we show that p53, one of the most commonly inactivated tumor suppressors in glioma, is a gatekeeper of astrocyte fate. In the context of stab-wound injury, p53 loss destabilized the identity of astrocytes, priming them to dedifferentiate in later life."
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00152-5
'Diverse animals such as corals, polychaete worms, and certain fishes are thought to synchronize their reproductive behavior by the moon. Such animals—including more than 100 coral species at the Great Barrier Reef—release their eggs before fertilization takes place, and synchronization maximizes the probability of an encounter between eggs and sperm.'
Great cover for the current issue of @CellMetabolism
@sentient_water The previous vice chancellor, Louise Richardson, actively defended the policy:
"She has warned against the “cancellation” of benefactors, whether the colonialist Cecil Rhodes or the opioid-seller Mortimer Sackler. "
https://www.ft.com/content/b6e002a6-4fab-49c5-977b-a6f49d38d52e
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
