Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
NEW ESSAY: The Power of Artemisia Gentileschi’s JUDITH AND HER MAIDSERVANT WITH THE HEAD OF HOLOFERNES
A breakdown of a vital piece of fine art from my childhood by Renaissance master Artemisia Gentileschi.
#art #artist #femaleartist #finearts #classicalart #renaissanceart #ArtemisiaGentileschi #womeninart #trailblazerss #culture #feminism
"Biotechnology has quietly become America’s newest national security concern. From Congress to the intelligence agencies, Washington’s leaders have concluded that control over biotechnologies will be critical not only to the country’s health, but to national security as well."
https://www.ft.com/content/cb9cd845-e9b0-4243-97f3-c315dac11fb4
'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al
#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity
Thiago Carvalho
boosted
FUNDING AND SCHOLARSHIPS FOR STUDENTS Identifying drug targets for TDP43 proteinopathies. Exeter Biomedical Research Centre - NIHR funded PhD Studentship for 2023/24 Entry Ref: 4714 Dr Akshay Bhinge University of Exeter, Streatham Campus https://www.exeter.ac.uk/study/funding/award/?id=4714
'One problem is that many schoolteachers have no science background, but that will change when science becomes a compulsory subject in the teacher training bachelor’s course, starting in the 2024–5 academic year.'
Thiago Carvalho
boosted
👆One-stop shop for integrative analysis of all your high throughput regulatory genomics data
Fantastic paper from @vanvanka123
https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1
'The market, let alone public taste, had yet to catch up. ‘If this is art, then I’m a horse’s ass,’ said Fiorello La Guardia, the mayor of New York City, when Arshile Gorky’s murals were unveiled at Newark Airport in 1937.'
Exploratory Grants for Climate Change and Health Research Center Development (P20 Clinical Trial Optional)
RFA-ES-23-007
Available Due Dates: May 01, 2023; November 07, 2023
Expiration Date: Nov 8, 2023
It's a very good question:
"But Recovery’s incredible success should prompt us to ask a more challenging question: why don’t we do this more often? The question of which drugs to use was far from the only unknown we had to navigate in the early days of the pandemic. Consider the decision to delay second doses of the vaccine, when to close schools, or the right regime for Covid testing. In each case, the UK took a calculated risk and hoped for the best. But as the Royal Statistical Society pointed out at the time, it would have been cheap and quick to undertake trials so we could know for sure what the right choice was, and then double down on it."
https://www.theguardian.com/books/2023/mar/06/the-big-idea-should-governments-run-more-experiments
Thiago Carvalho
boosted
Just Published!
"Fibrosis and Immunotherapy in Hepatocellular Carcinoma"
https://link.springer.com/chapter/10.1007/16833_2022_122
#Cancer #CancerResearch #DrugDiscovery #DrugDevelopment #Therapy #Immunotherapy
Thiago Carvalho
boosted
Self-directed Abs (autoantibodies) against specific chemokines (cell secreted proteins) are linked with protection from #LongCovid
https://www.nature.com/articles/s41590-023-01445-w @natimmunol
'But she warned: “One of the biggest and most realistic risks is that the people who could benefit most won’t be able to access or afford them.” Doudna and the other experts who talked to the Guardian are on the summit’s organising committee but shared their thoughts in a personal capacity.'
Thiago Carvalho
boosted
👉 During development, #Netrin1 is released and diffusible in the microenvironment. This study shows that in #cancer, #Netrin1 accumulates in the #ExtracellularMatrix. The authors used this property to follow its in vivo accumulation by radiolabeling and to target netrin-1-expressing tumor cells with #radioimmunotherapy.
By D. Kryza, P. Mehlen, D. Sarrut, B. Gibert & colleagues
Full #openaccess article 🗞️ : https://doi.org/10.15252/emmm.202216732
Thiago Carvalho
boosted
#CLN1 disease is caused by a deficiency of palmitoyl-protein thioesterase 1 (PPT1). This is one of the most aggressive childhood neurodegenerative diseases with unmet medical needs. Here, the authors provide evidence of the efficacy of a novel approach of #HematopoieticStemCell -based #GeneTherapy in the #CLN1 mouse model.
By M. Peviani, A. Biffi & colleagues
Thiago Carvalho
boosted
1/5
🦠 A Few More #Mpox ( #MonkeyPox) Pandemic Updates 🦠
"Assuming APOBEC-editing is characteristic of [mpox] infection in human hosts, we propose an APOBEC clock that – at a rate of ~6 APOBEC3 mutations per year – estimates [mpox] has been circulating in humans since 2016."
https://www.biorxiv.org/content/10.1101/2023.01.23.525187v1
Thiago Carvalho
boosted
When elephants are not like E. coli:
“That time was the beginning of cloning of human genes. She (Shirley Tilghman) cloned the beta globin gene. People went to listen to her seminar (at the NIH) and she presented this amazing discovery that when looking at the electron microscope of the hybridization of the globin message and the gene that they had cloned, there was a piece of the gene that was not in the message.”
From the #EMBOPodcast with Roberto di Lauro, who was a group leader at the EMBL, a professor at the University of Naples Federico II, served as President of the Stazione Zoologica Anton Dohrn, and the scientific attaché to the Italian Embassy in London.
#EMBOPodcast
https://www.embo.org/podcasts/we-should-know-more-this-is-our-main-job/
Thiago Carvalho
boosted
I can't believe I missed this podcast last year: Ta-Nehisi Coates on Tony Judt
cc @mucida
🎧 👇
https://www.publicbooks.org/primary-sources-ta-nehisi-coates-on-tony-judt/
Thiago Carvalho
boosted
A tiger for art lovers and Clive Barker fans by @hunchbacksociety
#ceramics #ceramic #ceramicart #handmade #ArtMastodon
Thiago Carvalho
boosted
March 6, 1866, died #OTD, philosopher & historian of #science William Whewell. He coined many concepts in #geology - like catastrophism & uniformitarianism - and was especially interested in mineralogy - Whewellite was named in his honor 💎 #MineralMonday
Thiago Carvalho
boosted
If you're organising a #meeting and would like support to reduce the #environmental impact of your event, our #Sustainable Conferencing #Grants might be able to help.
@BritishNeuro used their grant to offer ‘Train over Plane’ travel grants. These grants reimbursed BNA members who chose to travel to the meeting by train, coach or carshare, rather than catching a plane. Find out more here:
Details about our meeting grants can be found here:
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
