Thiago Carvalho @cyrilpedia@qoto.org

'Last July the first predictive clinical test based on the gut microbiome was approved in Europe. The test, called BiomeOne, was developed by Vienna-based biotech BiomeDx. It analyzes the DNA in gut microbes of patients with cancer and predicts who are most likely to have success with immunotherapy.'

https://www.nature.com/articles/s41587-023-01677-z?utm_source=linkedin&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO

"Research has repeatedly shown that Black mothers and babies have the worst childbirth outcomes in the United States. But this study is novel because it’s the first of its size to show how the risks of childbirth vary by both race and parental income, and how Black families, regardless of their socioeconomic status, are disproportionately affected."

https://www.nytimes.com/interactive/2023/02/12/upshot/child-maternal-mortality-rich-poor.html

Portrait with poncho & bees.

(Photo by Karen Liu, who's on Mastodon somewhere)

"For a wealthy country, the United States is a dangerous place to be a newborn. But it is not equally risky for all babies."

https://www.nytimes.com/interactive/2023/02/12/upshot/child-maternal-mortality-rich-poor.html

"We show that self-renewing DRGMacs contribute to promote axon regeneration. Using single-cell transcriptomics data and CellChat to simulate intercellular communication, we reveal that macrophages express the neuroprotective and glioprotective ligand prosaposin and communicate with SGCs via the prosaposin receptor GPR37L1."

#immunology #Macrophage #neuroscience #Regeneration

https://www.pnas.org/doi/10.1073/pnas.2215906120

'Carlos Moedas faz o que a Igreja manda desde que o tema seja a construção civil. O altar-palco pode custar rios de dinheiro para receber o Papa Francisco, porque a Igreja quer. Mas a doutrina social da Igreja e a palavra de Francisco não valem um chavo se estiver em causa o acolhimento a imigrantes.'

https://www.publico.pt/2023/02/12/politica/opiniao/ventura-nao-so-montenegro-tambem-ja-discurso-xenofobo-2038566

"A single, severe episode of stress can bring about myriad responses amongst individuals, ranging from cognitive enhancement to debilitating and persistent anxiety; however, the biological mechanisms that contribute to resilience versus susceptibility to stress are poorly understood."

#Preprint #neuroscience

https://www.biorxiv.org/content/10.1101/2023.02.08.527777v1?med=mas

'At least, this late in the pandemic, families can be with their loved ones at the end of life. When the family agreed to remove Mr. Caretti from the ventilator and provide comfort care, “he was alert, very aware of what was happening,” his son said. “He was holding everyone’s hand.” He died a few hours later, on Dec. 14.'

https://www.nytimes.com/2023/02/11/health/covid-pandemic-seniors.html

"Here, we investigate a β-cyclodextrin nanoparticle (CDNP) formulation encapsulating the Toll-like receptor 7 and 8 (TLR7/8) agonist R848 (CDNP-R848) to reprogram myeloid cells in the glioma microenvironment."

#immunology #TollLikeReceptor #InnateImmunity #Immunotherapy

https://www.nature.com/articles/s41467-023-36321-6

'Virulence of C. difficile also has an intimate relationship with nutrient availability as, upon nutrient limitation in the gut environment, C. difficile responds by producing toxins that liberate host-derived nutrients through cytotoxic activity and creation of a proinflammatory environment'

#Clostridium #InfetionImmunity "Metabolism #Microbiology

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011034

The fly
#Ceramics

https://madalenaparreira.com/Hunchbacksociety