Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'I was struggling to update my corkboard when I read this exquisitely pulpy line: “Lawler was a New York blue blood who married a nouveau riche nobody named Constantine Psomas — a.k.a. the can man.” Warmth filled my guts like whiskey. I didn’t need a map. Mosley was driving me to Rikers in a cream-colored Bianchina, and Mingus was playing on the stereo. I was along for the ride.'
"The idea that I wanted to address is the impression that some parts of the public have now that vaccine development is apparently not all that hard."
https://www.science.org/content/blog-post/there-are-vaccines-and-there-are-vaccines
"We identified and validated APOBEC3A and APOBEC4 as novel #ribosome biogenesis factors through our laboratory's established screening platform for the discovery of regulators of nucleolar function in MCF10A cells."
@gpollara Comparing the IRF1 deficiency phenotype in this paper to the gamma interferon pathway mutants extensively described might generate some clues
Thiago Carvalho
boosted
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs
"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"
#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis
Thiago Carvalho
boosted
RT @cggbamford
As far as discussions on virus taxonomy - or taxonomy in general - go, this is a great read and highlights challenges and opportunities in organising the virosphere https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001922
Thiago Carvalho
boosted
Population Genetic Considerations Regarding Evidence for Biased Mutation Rates in Arabidopsis thaliana https://doi.org/10.1093/molbev/msac275 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
Immunotherapy Physician Scientist Fellow
#ScienceJobs #job
Seattle #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/fred-hutchinson-cancer-center-27778-immunotherapy-physician-scientist-fellow/?feed_id=38648
Thiago Carvalho
boosted
This morning in 1971, a teletype operator at the National Emergency Warning Center in Cheyenne Mountain, Colorado, mistakenly transmitted a message via the Emergency Broadcast System notifying radio and TV stations nationwide the United States was under attack. http://conelrad.blogspot.com/2010/09/code-word-hatefulness-great-ebs-scare.html
Thiago Carvalho
boosted
Genome editing for the potential of curing diseases is taking off in directions that were not anticipated. I reviewed its recent and accelerated pace of progress
https://erictopol.substack.com/p/towards-genome-editing-cure-of-genetic
"In his 1821 book, “A Defense of Poetry,” Percy Shelley writes that an artist must learn to imagine what he knows. For many artists, the verdict of macular degeneration might have been disabling, or at least discouraging. For Jules, it was an invitation to imagine what he knew."
Details
"El problema de diseñar proteínas está resuelto. El reto es saber formular el problema que queremos resolver. Necesitamos una hipótesis molecular. Y para eso hay que comprender el origen de la enfermedad."
“Alongside the desacralisation and secularisation of public life,” Rovelli argues, “which passed from the hands of divine kings to those of citizens, came the desacralisation and secularisation of knowledge… law was not handed down once and for all but was instead questioned again and again.”
Thiago Carvalho
boosted
How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member https://doi.org/10.1093/molbev/msad014 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
"The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate the role of γc cytokines in inflammatory and autoimmune disease settings. Here, we generated a γc cytokine receptor antibody, REGN7257, to determine whether γc cytokines might be targeted for T cell–mediated disease prevention and treatment."
Thiago Carvalho
boosted
"Ever since, he has been exploring organoid opportunities — in drug screening, disease modelling, clinical trial design and personalized medicine — in his academic lab, through biotechs and via scientific advisory boards. When he was offered the job as the head of Pharma Research & Early Development (pRED) at Roche, he jumped at the chance to take this organoid research to the next level."
"Together, our findings indicate that the AIM assay can be an effective tool for relative quantification of murine Ag-specific CD4+ T cells to protein vaccination, while demonstrating its limitations during conditions of acute and chronic infection."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
