Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
That turned out to be a very good move:
"In 1956 I reviewed for Virology a note by Groupé and Manaker reporting an assay of RSV in cell culture by production of transformed foci (21). A significant difference from my efforts to assay RSV in culture was their addition of tryptose phosphate broth to the medium. I enlisted Howard Temin, a first-year graduate student in embryology, to help in adaptation of the RSV focus assay to Dulbecco's monolayer assay of cytocidal viruses "
Less is more for monoclonal antibody affinity?
(Particularly if deletion is not the goal)
"This approach delivered higher immune cell activation, in vivo T cell expansion and antitumour activity in the case of CD40. Moreover, an inert anti-4-1BB monoclonal antibody was transformed into an agonist. Low-affinity variants of the clinically important antagonistic anti-PD-1 monoclonal antibody nivolumab also mediated more potent signalling and affected T cell activation."
#Monoclonal #MonoclonalAntibody #immunology #drugdiscovery #drugdevelopment
"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183
Thiago Carvalho
boosted
Postdoc fellow opportunity in the group of Sheena Radford: https://jobs.leeds.ac.uk/vacancy.aspx?ref=FBSAS1057 Advertised as focused on #NMR in context of #amyloid formation. Deadline in March 2023. (Check the link!) #nmrchat
At the CRG-Barcelona:
"The Severo Ochoa IMPULSE Visitor Program call is now open!
Apply if you would like to have access to the Core Technologies, Scientific Resources and Business and Development capacities available at the CRG. You will be hosted by CRG groups or Core Technology units and will integrate into the group activities."
https://www.crg.eu/en/content/careers-job-opportunities/impulse-2023
A #preprint with a new method that could allow detecting a mutation in its infant stage, when it's still just a mismatch:
"Here, we developed a single-molecule, long-read sequencing method that achieves single-molecule fidelity for single-base substitutions when present in either one or both strands of the DNA."
Thiago Carvalho
boosted
As part of the March 9
#JoinMastodonDay effort:
https://neuromatch.social/@elduvelle/109861042649284737,
@elduvelle, @noellemitchell, @alexwild
I suggest that we each email 1 individual & 1 organization with an invite/nudge.
You in?
A mysterious 1st century Roman tower just outside the town of Belmonte (Portugal) - no knows what it was: home, military watchtower, administrative building, trading center or something else entirely.
"And a grim report today in The Lancet and being presented at a conference in Seattle, which analyzes the death last summer in Mexico and the cases of 381 other mpox patients who also had advanced HIV infections, makes clear the disease poses an enormous risk to those living with uncontrolled HIV. Of the 179 patients with less than 200 CD4 cells per microliter—more than 500 is considered normal—27 died."
Thiago Carvalho
boosted
Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells
Thiago Carvalho
boosted
Conceptualizing microbe–plasmid communities as complex adaptive systems
@TrendsMicrobiol Opinion by @shaipilo
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(23)00025-2
Thiago Carvalho
boosted
"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"
#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis
Thiago Carvalho
boosted
"The idea that I wanted to address is the impression that some parts of the public have now that vaccine development is apparently not all that hard."
https://www.science.org/content/blog-post/there-are-vaccines-and-there-are-vaccines
Thiago Carvalho
boosted
THE CASE FOR FREE-RANGE LAB MICE
🧵 A THREAD on my new @NewYorker story
https://www.newyorker.com/culture/annals-of-inquiry/the-case-for-free-range-lab-mice
Thiago Carvalho
boosted
Modeling work from Gjorgjieva’s lab on turtle visual cortex reveals the role of weak synaptic connections among neurons:
“rare strong connections support sequence propagation, while dense weak connections modulate propagation reliability.”
“Applying external inputs to specific neurons in the sparse backbone of strong connections can effectively control propagation and route activity within the network.”
Thiago Carvalho
boosted
This paper provides an excellent overview
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01184-0
"Si dos medicamentos se parecen demasiado, por el nombre o el envase, el hospital puede buscar una alternativa con menores riesgos. A veces esto no es posible, y entonces se utilizan otras medidas como las llamadas tall man letters (las letras del hombre alto, en inglés), que destacan en mayúsculas las letras diferentes en nombres parecidos. Un ejemplo seria “cloZApina” y “cloTIApina”, dos antipsicóticos."
Thiago Carvalho
boosted
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
