Thiago Carvalho @cyrilpedia@qoto.org

A Retired Math Teacher Helps Students Learn Geometry Through Quilting

https://www.openculture.com/2023/02/a-retired-math-teacher-helps-students-learn-geometry-through-quilting.html via @openculture

"Here we report a murine model that expresses tumor-like levels of human APOBEC3B after Cre-mediated recombination. Animals appear to develop normally with full-body expression of APOBEC3B. However, adult males manifest infertility and older animals of both sexes show accelerated rates of tumorigenesis (mostly lymphomas or hepatocellular carcinomas)"

https://www.biorxiv.org/content/10.1101/2023.02.24.529970v1

Does accumulation of #macromolecules in the highly protein-rich #mitochondrial matrix regulate solute diffusion and biochemical reactions?
Using FRAP analysis of #organelle-targeted fusion peptides, Werner Koopman and colleagues report macromolecular crowding as a stress-dependent determinant of matrix mobility and viscosity

https://www.embopress.org/doi/10.15252/embj.2021108533

01/2023 Issue ➡️ http://bit.ly/3CMpyKi
On the cover: Engineered bacteria expressing a designed single-chain IL-10 prevent severe inflammation in Pseudomonas aeruginosa lung infection
Luis Serrano lab, CRG
#proteinengineering #immunomodulation #synbio #SystemsBiology

My thoughts on the Met’s new Lohengrin:

https://bachtrack.com/review-lohengrin-girard-beczala-wilson-nezet-seguin-metropolitan-opera-february-2023

Intro: I'm a #Biology professor researching the #Neurogenetics of #learning and #memory in #Drosophila. I study how operant or motor memories are formed and how other forms of learning regulate these processes. As spontaneous behavior is required for operant learning, I also study how #spontaneity arises in nervous systems.

Our lab practices #openscience

Disclaimer: Since I got tenure in 2012, my non-tenured co-authors decide where our manuscripts are submitted.

Thinking about the NYT (and other) pieces about the collapse of both time and world view in pandemic, and pieces in Atlantic (and elsewhere) about the collapse of time and post #ww2 worldview in the accumulating/ staggering local and global crises. These are such deeply related phenomena. Braudel had some things very right in terms of how we think about human history and what matters and when. #history #DeepTime #Braudel #histodons

"Several of the world’s biggest pharmaceutical companies are fighting shareholder proposals to force them to disclose information on their use of a controversial patent strategy that can delay rivals from launching cheaper versions of blockbuster drugs.

A coalition of ethical investors have asked Johnson & Johnson, Merck, Pfizer, Eli Lilly, Gilead, Amgen, Regeneron, Bristol Myers Squibb and AbbVie to publish a report on the process they follow when applying for multiple patents on a single drug."

https://www.ft.com/content/c5498e67-a48f-4adc-b85f-7bf1a0d400f6

Fasted bones grow fast later: chondroprogenitors in the growth plate of murine long bones adapt to dietary restriction, leading to catch-up growth during refeeding. 🦴

Members of the #RoselloDiez Lab #MonashUni highlight a #preprint from Motomi Iwamoto-Enomoto and team #UofMaryland.

Another excellent addition to the preList celebrating #preLights5thBirthday.

📜 https://prelights.biologists.com/highlights/nutrient-regulated-dynamics-of-chondroprogenitors-in-the-postnatal-murine-growth-plate/

In the most recent episode we caught up with @PSarkies from University of Oxford Biochemistry to talk about his work on #Transgenerational Inheritance of #Epimutations. #chromatin #epigenetics #podcast @epigenetics

Listen here:

https://activemotif.com/podcasts#peter-sarkies

📢 Hybrid symposium on reforming research assessment: how to implement responsible procedures and move beyond impact factors and h-index?
📅 13.03.2023, 14:30-16:30
📌 Munich and Zoom
🎫 https://www.osc.uni-muenchen.de/news/symposium_13_03_2023/index.html